Standing Watch: Immune Activation and Failure in Melanoma Sentinel Lymph Nodes

Lund, Amanda W.

doi:10.1158/1078-0432.ccr-22-0214

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…Further, SC immune mapping of melanoma sentinel lymph nodes (SLNs) identified immunological changes that compromise anti-melanoma immunity and contribute to a high relapse rate 41 . The progressive immune dysfunction found to be associated with micro-metastasis in patients with stage I–III cutaneous melanoma may motivate new hypotheses for neoadjuvant therapy with potential to reinvigorate endogenous antitumour immunity 42 . A similar suppressed immune environment was observed in acral melanoma compared with that of cutaneous melanoma from non-acral skin 43 .…”

Section: Applications In Drug Discovery and Developmentmentioning

confidence: 99%

Applications of single-cell RNA sequencing in drug discovery and development

Sande

Lee

Mutasa-Gottgens

et al. 2023

Nat Rev Drug Discov

132

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Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods, together with associated computational tools and the growing availability of public data resources, are transforming drug discovery and development. New opportunities are emerging in target identification owing to improved disease understanding through cell subtyping, and highly multiplexed functional genomics screens incorporating scRNA-seq are enhancing target credentialling and prioritization. ScRNA-seq is also aiding the selection of relevant preclinical disease models and providing new insights into drug mechanisms of action. In clinical development, scRNA-seq can inform decision-making via improved biomarker identification for patient stratification and more precise monitoring of drug response and disease progression. Here, we illustrate how scRNA-seq methods are being applied in key steps in drug discovery and development, and discuss ongoing challenges for their implementation in the pharmaceutical industry.

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Section: Applications In Drug Discovery and Developmentmentioning

confidence: 99%