Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT-TRD) induces rapid remission from treatment-resistant depression in a double-blinded, randomized, and controlled trial.

Phillips, Angela; Cole, Eleanor; Bentzley, Brandon S.; Stimpson, Katy H.; Nejad, Romina; Tischler, Claudia; Barmak, Fahim; Veerapal, Clive; Khan, Naushaba; Cherian, Kirsten; Felber, Emily; Brown, Randi; Choi, Elizabeth; Bishop, James; Azeez, Azeezat; Coetzee, John P.; Rapier, Rachel; Odenwald, Nicole; Carreon, David; Hawkins, Jessica; Chang, Maureen; Espil, Flint M.; Schatzberg, Alan F.; Sudheimer, Keith; Williams, Nolan

doi:10.1016/j.brs.2020.06.071

Cited by 3 publications

(2 citation statements)

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Section: Obstacles To the Current Care Delivery Model And Effectiveness Issuesmentioning

confidence: 84%

“…78,79 These unprecedented results garnered international attention, and the group recently reported having completed a sham-controlled RCT. 108 Active treatment was significantly superior to the sham group, with 78.6% remission rate in the active group (N = 14) and 13.3% remission rate in the sham group (N = 15). In summary, arTMS may lead to shorter treatment duration while maintaining or improving overall effectiveness, which could make it easier for patients to attend a full course of treatment.…”

Section: Treatment Accelerationmentioning

confidence: 84%

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Repetitive transcranial magnetic stimulation for major depressive disorder: basic principles and future directions

Miron

Jodoin

Lespérance

et al. 2021

Therapeutic Advances in Psychopharmacology

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Repetitive transcranial magnetic stimulation (rTMS) is a safe and well-tolerated intervention for major depressive disorder (MDD). Over 150 randomized controlled trials (RCTs) have been carried out, and its efficacy has been confirmed in dozens of meta-analyses. Real world data has also confirmed the effectiveness of rTMS for MDD in clinical practice, with the most recent literature indicating response rates of 40–50% and remission rates of 25–30%. In this review, we first offer an historical perspective, followed by a review of basic principles, such as putative mechanisms, procedures and protocols, stimulation targets, efficacy and durability of response, side effects, and the placebo controversy. In the second part of this review, we first discuss solutions to increase accessibility to rTMS, such as modifications to treatment equipment, protocols and setting. We continue with possible means to further increase effectiveness, such as treatment personalization and extension. We conclude by addressing the scheduling issue, with accelerated rTMS (arTMS) as a possible solution.

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Section: Obstacles To the Current Care Delivery Model And Effectiveness Issuesmentioning

confidence: 84%

Section: Treatment Accelerationmentioning

confidence: 84%

Repetitive transcranial magnetic stimulation for major depressive disorder: basic principles and future directions

Miron

Jodoin

Lespérance

et al. 2021

Therapeutic Advances in Psychopharmacology

View full text Add to dashboard Cite

show abstract

Neuromodulation Therapies II: Repetitive Transcranial Magnetic Stimulation and Deep Brain Stimulation

McMurray,

Tremblay,

Lazaro

et al. 2024

Geriatric Psychiatry

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A review of diffusion MRI in mood disorders: mechanisms and predictors of treatment response

Al-Sharif,

Zavaliangos-Petropulu,

Narr

2024

Neuropsychopharmacol.

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Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT-TRD) induces rapid remission from treatment-resistant depression in a double-blinded, randomized, and controlled trial.

Cited by 3 publications

References 0 publications

Repetitive transcranial magnetic stimulation for major depressive disorder: basic principles and future directions

Repetitive transcranial magnetic stimulation for major depressive disorder: basic principles and future directions

Neuromodulation Therapies II: Repetitive Transcranial Magnetic Stimulation and Deep Brain Stimulation

A review of diffusion MRI in mood disorders: mechanisms and predictors of treatment response

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