Stanniocalcin-1 and -2 effects on glucose and lipid metabolism in white adipose tissue from fed and fasted rats

Abstract

Stanniocalcin-1 and -2 belong to a family of molecules that exhibit both paracrine and autocrine effects in mammalian cells. Human stanniocalcin-1 (hSTC-1) is expressed in a wide range of tissues, including white adipose tissue. In fed rats, hSTC-1 increases carbon flux from glucose to lipids in retroperitoneal white adipose tissue. Human stanniocalcin-2 (hSTC-2) is expressed in almost all tissues and regulates various biological processes. The aim of this work was to study the action of hSTC-1 and hSTC-2 in the lipid and glucose metabolism of epididymal white adipose tissue (eWAT) in rats in different nutritional states. This study shows for the first time an opposite effect of hSTC-1 and hSTC-2 on glyceride-glycerol generation from glucose in eWAT of fed rats. hSTC-1 stimulated the storage of triacylglycerol in eWAT in the postprandial period, increasing glucose uptake and glyceride-glycerol generation from 14C-glucose. hSTC-2 decreased triacylglycerol synthesis, reducing glyceride-glycerol generation from 14C-glucose, direct phosphorylation of glycerol, and fatty acid synthesis from 14C-glucose in eWAT of fed rats. However, both hormones increased glucose uptake in fed and fasting states. These findings provide evidence for a direct role of hSTC-1 and hSTC-2 in the regulation of lipid and glucose metabolism in eWAT of rats.

New Insights Into Physiological and Pathophysiological Functions of Stanniocalcin 2

“…In liver, putative stanniocalcin receptor was present in hepatocytes as detected by punctate staining, especially on cell membranes near central vein (12). Therefore, based on the current immunological data, it is conceivable that STC2 is bound to the putative stanniocalcin receptor(s) and might function in an autocrine and/or paracrine fashion as speculated by various groups (5,6,12,44).…”

“…STC2 has also been involved in deregulation of glycaemia in obese mice as well as in type 2 diabetes mellitus patients (8). Additionally, it was speculated that STC2 might play role in glucose uptake and metabolism, glycogen storage and triacylglycerol synthesis in both brown and white adipose tissues (44,63). Taken together STC2 exhibits pro-survival effect in various model systems.…”

Deimination Protein Profiles in Alligator mississippiensis Reveal Plasma and Extracellular Vesicle-Specific Signatures Relating to Immunity, Metabolic Function, and Gene Regulation

“…Stanniocalcin is a secreted glycoprotein, originally studied in fish as hormone regulator of serum calcium levels (209). It is expressed in a wide range of tissues and regulates various biological processes including lipid and glucose metabolism (210,211), the growth hormone-insulin-like growth factor axis (212), as well as cellular calcium and phosphate homeostasis (213,214). STC2 is related to growth restriction (209) and organomegaly when overexpressed at the genetic level (215).…”

LAIR-1 overexpression inhibits epithelial–mesenchymal transition in osteosarcoma via GLUT1-related energy metabolism

“…STC1, as well as STC2, was originally identified as a calcium/phosphate-regulating hormone. Recent studies have indicated that the STC-1 gene is closely related to glucose and lipid metabolism as well as to mitochondrial function [ 29 , 30 ]. In addition, PARP or PAR alterations have been described in tumors, specifically those influencing EMT [ 31 – 33 ].…”