Staphylococcal cassette chroromosome mec (SCCmec) typing of methicillin-resistant Staphylococcus aureus (MRSA) isolates from patients attending Tengku Ampuan Afzan hospital (HTAA) in Kuantan, Pahang, Malaysia

Mustafa, Mohammed Imad; Alarosi, N. A.; Amjad, Nasser Mohammad

doi:10.1016/j.ijid.2012.05.594

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“…This is also true for Malaysia, as demonstrated by Ghaznavi-Rad et al, where they documented 20% of SCC mec type III and 72.8% of SCC mec type IIIA in their isolates [67]. Other studies corroborating this finding include Neela et al, with 41.6% of type III and 52.7% of type IIIA [68], and Mustafa et al, who reported 78.5% of type III in their isolates collected from Hospital Tengku Ampuan Afzan [79]. Two other studies in 2009 and 2011 also have similar results with the former study and reported 90% of type III and the latter detected the same type in 96.8% (608/628) MRSA isolates [18,69].…”

Section: Clonal Types and Characteristics Of Malaysian S Aureus Imentioning

confidence: 74%

Staphylococcus aureus Infections in Malaysia: A Review of Antimicrobial Resistance and Characteristics of the Clinical Isolates, 1990–2017

et al. 2019

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Staphylococcus aureus is an important nosocomial pathogen and its multidrug resistant strains, particularly methicillin-resistant S. aureus (MRSA), poses a serious threat to public health due to its limited therapeutic options. The increasing MRSA resistance towards vancomycin, which is the current drug of last resort, gives a great challenge to the treatment and management of MRSA infections. While vancomycin resistance among Malaysian MRSA isolates has yet to be documented, a case of vancomycin resistant S. aureus has been reported in our neighboring country, Indonesia. In this review, we present the antimicrobial resistance profiles of S. aureus clinical isolates in Malaysia with data obtained from the Malaysian National Surveillance on Antimicrobial Resistance (NSAR) reports as well as various peer-reviewed published records spanning a period of nearly three decades (1990–2017). We also review the clonal types and characteristics of Malaysian S. aureus isolates, where hospital-associated (HA) MRSA isolates tend to carry staphylococcal cassette chromosome mec (SCCmec) type III and were of sequence type (ST)239, whereas community-associated (CA) isolates are mostly SCCmec type IV/V and ST30. More comprehensive surveillance data that include molecular epidemiological data would enable further in-depth understanding of Malaysian S. aureus isolates.

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