Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity reactions via the platelet-activating factor receptor

Zhang, Qiwei; Mousdicas, Nico; Yi, Qiaofang; Al-Hassani, Mohammed; Billings, Steven D.; Perkins, Susan M.; Howard, Katherine M.; Ishii, Satoshi; Shimizu, Takao; Travers, Jeffrey B.

doi:10.1172/jci25429

Cited by 49 publications

(72 citation statements)

References 38 publications

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“…Staphylococcal aureus produces lipoteichoic acid to prevent delayed-type hypersensitivity reactions through activation of the plateletactivating factor receptor. 39 In addition, Salmonella protects epithelial cells from apoptosis by sustained activation of Akt through the effector protein SopB. 40 Interestingly, lowmolecular-weight factors secreted by LGG (<10 kilodaltons) have been reported to stimulate Hsp25 and Hsp72 production by intestinal epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

Soluble Proteins Produced by Probiotic Bacteria Regulate Intestinal Epithelial Cell Survival and Growth

et al. 2007

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Background & Aims-Increased inflammatory cytokine levels and intestinal epithelial cell apoptosis leading to disruption of epithelial integrity are major pathologic factors in inflammatory bowel diseases. The probiotic bacterium Lactobacillus rhamnosus GG (LGG) and factors recovered from LGG broth culture supernatant (LGG-s) prevent cytokine-induced apoptosis in human and mouse intestinal epithelial cells by regulating signaling pathways. Here, we purify and characterize 2 secreted LGG proteins that regulate intestinal epithelial cell antiapoptotic and proliferation responses.

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Section: Discussionmentioning

confidence: 99%

Soluble Proteins Produced by Probiotic Bacteria Regulate Intestinal Epithelial Cell Survival and Growth

et al. 2007

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“…Ear tissue was removed and bisected. Part was submitted for formalin fixation and paraffinembedding for H&E staining and TNF-␣ immunohistochemistry, respectively, as described previously (38,45). Part of the ear tissue was also placed in RNAlater (Ambion) for measurement of TNF-␣ mRNA levels as described previously (32).…”

Section: Methodsmentioning

confidence: 99%

Platelet-activating Factor Receptor Agonists Mediate Xeroderma Pigmentosum A Photosensitivity

Yao

Harrison

Al-Hassani

et al. 2012

Journal of Biological Chemistry

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Background: Deficiency of the nucleotide excision repair protein xeroderma pigmentosum type A (XPA) is characterized by photosensitivity. Results: XPA-deficient cells and mice generate increased platelet-activating factor (PAF), oxidized glycerophosphocholines, and skin inflammation following ultraviolet B radiation with the skin inflammation blocked by PAF antagonists. Conclusion: PAF-R signaling mediates photosensitivity seen in XPA deficiency. Significance: These studies provide important insights into the mechanisms of photosensitivity.

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“…PAF binds to a specific receptor (PAFR), which is found on a wide variety of cells, including platelets, monocytes, mast cells, polymorphonuclear lymphocytes, DCs, and keratinocytes (13). PAF is produced by physical stress, including UV light and trauma (14). PAF is involved in UVB, psoralen plus UVA light, and jet fuel-induced immune suppression (13,15,16).…”

Section: Endritic Cells (Dcs)mentioning

confidence: 99%

“…PAF is involved in UVB, psoralen plus UVA light, and jet fuel-induced immune suppression (13,15,16). PAF also plays a role in regulating the immune response to microbial pathogens (14). PAF binding results in the production of numerous cytokines (13,17,18).…”

Section: Endritic Cells (Dcs)mentioning

confidence: 99%

Dermal Dendritic Cells, and Not Langerhans Cells, Play an Essential Role in Inducing an Immune Response

Fukunaga

Khaskhely

Sreevidya

et al. 2008

The Journal of Immunology

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Langerhans cells (LCs) serve as epidermal sentinels of the adaptive immune system. Conventional wisdom suggests that LCs encounter Ag in the skin and then migrate to the draining lymph nodes, where the Ag is presented to T cells, thus initiating an immune response. Platelet-activating factor (PAF) is a phospholipid mediator with potent biological effects. During inflammation, PAF mediates recruitment of leukocytes to inflammatory sites. We herein tested a hypothesis that PAF induces LC migration. Applying 2,4-dinitro-1-fluorobenzene (DNFB) to wild-type mice activated LC migration. In contrast, applying DNFB to PAF receptor-deficient mice or mice injected with PAF receptor antagonists failed to induce LC migration. Moreover, after FITC application the appearance of hapten-laden LCs (FITC+, CD11c+, Langerin+) in the lymph nodes of PAF receptor-deficient mice was significantly depressed compared with that found in wild-type mice. LC chimerism indicates that the PAF receptor on keratinocytes but not LCs is responsible for LC migration. Contrary to the diminution of LC migration in PAF receptor-deficient mice, we did not observe any difference in the migration of hapten-laden dermal dendritic cells (FITC+, CD11c+, Langerin−) into the lymph nodes of PAF receptor-deficient mice. Additionally, the contact hypersensitivity response generated in wild-type or PAF receptor-deficient mice was identical. Finally, dermal dendritic cells, but not LCs isolated from the draining lymph nodes after hapten application, activated T cell proliferation. These findings suggest that LC migration may not be responsible for the generation of contact hypersensitivity and that dermal dendritic cells may play a more important role.

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Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity reactions via the platelet-activating factor receptor

Cited by 49 publications

References 38 publications

Soluble Proteins Produced by Probiotic Bacteria Regulate Intestinal Epithelial Cell Survival and Growth

Soluble Proteins Produced by Probiotic Bacteria Regulate Intestinal Epithelial Cell Survival and Growth

Platelet-activating Factor Receptor Agonists Mediate Xeroderma Pigmentosum A Photosensitivity

Dermal Dendritic Cells, and Not Langerhans Cells, Play an Essential Role in Inducing an Immune Response

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