Staphylococcus aureus: colonizing features and influence of an antibacterial treatment in adults with atopic dermatitis

Breuer, Kristine; Häußler, Susanne; Kapp, Alexander; Werfel, Thomas

doi:10.1046/j.1365-2133.2002.04872.x

Cited by 284 publications

(276 citation statements)

References 45 publications

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“…According to the present state knowledge, S. aureus colonisation reaches 75 -100% in lesional skin of AD patients, and 30 -100% of AD patients have this bacteria in their nonlesional skin. By contrast, only 5 -30% of healthy people are carriers of S. aureus [5,14,15,16,17]. The results of this study were consistent with thethe above observations -S. aureus was isolated from the skin lesions of 81% of AD patients.…”

Section: Discussionsupporting

confidence: 82%

Skin and nasal vestibule colonisation by Staphylococcus aureus and its susceptibility to drugs in atopic dermatitis patients

Wróbel¹,

Tomczak²,

Jenerowicz³

et al. 2018

Ann Agric Environ Med.

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Introduction. Atopic dermatitis (AD) is a chronic and recurrent disease with an inflammatory background. Genetic and environmental factors are responsible for the occurrence and development of this dermatosis. Objective. The aim of the study was to assess the frequency of colonisation of the nasal vestibule and apparently healthy skin by S. aureus, and to assess dermal lesions for superinfection with S. aureus in AD patients. Materials and method. The research was performed on a population of 100 AD patients. Three smears were collected for microbiological investigations: from the anterior nares, from apparently healthy skin and from lesioned skin. On collection, the material was cultured on mediums provided by the bioMerieux and Argenta companies. The strains were identified and their sensitivity to antibiotics assessed by means of the Vitek2 system (bioMerieux). Results. S. aureus was present in at least one location in 90%. 44% presented S. aureus colonization of apparently healthy skin and within skin lesions. In the case of 23%, this particular pathogen was detected only in skin lesions, whereas 6% had a positive result within the area of apparently healthy skin. In total, S. aureus was detected in the skin of 73%. In 61%, apparently healthy skin had been colonized with S. aureus, whereas in 81% colonization was proved within the skin lesions. S. aureus was detected in the nasal vestibule of 85%. Among the group with S. aureus in their anterior nares, the pathogen was also found on the skin surface of 77%. Conclusions. S. aureus colonises skin in most AD patients. Most AD patients carry S. aureus in their nasal vestibules. S. aureus does not seem to colonise healthy skin as often as skin lesions in young people. The vast majority of S. aureus strains were sensitive to local antibiotics. Most S. aureus strains produced penicillinase.

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Section: Discussionsupporting

confidence: 82%

Skin and nasal vestibule colonisation by Staphylococcus aureus and its susceptibility to drugs in atopic dermatitis patients

Wróbel¹,

Tomczak²,

Jenerowicz³

et al. 2018

Ann Agric Environ Med.

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“…Various products of S. aureus, such as peptidoglycan (PGN) and superantigens, are known to induce the expression of proinflammatory cytokines in monocytes and dendritic cell (DC) subsets (6). Clinical observations showing an improvement of patients following antistaphylococcal therapy support a role for S. aureus in the pathogenesis of atopic dermatitis (7).…”

mentioning

confidence: 99%

CC Chemokine Ligand 18, An Atopic Dermatitis-Associated and Dendritic Cell-Derived Chemokine, Is Regulated by Staphylococcal Products and Allergen Exposure

Pivarcsi¹,

Gombert²,

Dieu-Nosjean

et al. 2004

The Journal of Immunology

110

117

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Atopic dermatitis is a chronic inflammatory skin disease with a steadily increasing prevalence. Exposure to allergens or bacterial superantigens triggers T and dendritic cell (DC) recruitment and induces atopic skin inflammation. In this study, we report that among all known chemokines CCL18/DC-CK1/PARC represents the most highly expressed ligand in atopic dermatitis. Moreover, CCL18 expression is associated with an atopic dermatitis phenotype when compared with other chronic inflammatory skin diseases. DCs either dispersed within the dermis or clustering at sites showing perivascular infiltrates are abundant sources of CCL18. In vitro, microbial products including LPS, peptidoglycan, and mannan, as well as the T cell-derived activation signal CD40L, induced CCL18 in monocytes. In contrast to monocytes, monocyte-derived, interstitial-type, and Langerhans-type DCs showed a constitutive and abundant expression of CCL18. In comparison to Langerhans cells, interstitial-type DCs produced higher constitutive levels of CCL18. In vivo, topical exposure to the relevant allergen or the superantigen staphylococcal enterotoxin B, resulted in a significant induction of CCL18 in atopic dermatitis patients. Furthermore, in nonatopic NiSO4-sensitized individuals, only relevant allergen but not irritant exposure resulted in the induction of CCL18. Taken together, findings of the present study demonstrate that CCL18 is associated with an atopy/allergy skin phenotype, and is expressed at the interface between the environment and the host by cells constantly screening foreign Ags. Its regulation by allergen exposure and microbial products suggests an important role for CCL18 in the initiation and amplification of atopic skin inflammation.

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“…Идентифицировано несколько видов суперантигенов стафилококка [7]. К клиническим особенностям, свидетельствующим о вторичной бактери-альной инфекции кожи, относят: мокнутие кожи, высыпания типа фолликулита, фурун-• кулез, импетиго и т. п.; асимметричное распределение очагов поражений; • системное поражение органов.…”

Section: вторичные инфекции кожиunclassified

Special Characteristics of Treatment of Severe Atopic Dermatitis in Children

Мачарадзе¹

2013

Vopr. sovr. pediatr.

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Staphylococcus aureus: colonizing features and influence of an antibacterial treatment in adults with atopic dermatitis

Abstract: S. aureus may play an important role as an aggravating factor in adults with AD, as antimicrobial treatment leads to a significant improvement of AD in patients who are colonized with the bacterium.

Cited by 284 publications

References 45 publications

Skin and nasal vestibule colonisation by Staphylococcus aureus and its susceptibility to drugs in atopic dermatitis patients

Skin and nasal vestibule colonisation by Staphylococcus aureus and its susceptibility to drugs in atopic dermatitis patients

CC Chemokine Ligand 18, An Atopic Dermatitis-Associated and Dendritic Cell-Derived Chemokine, Is Regulated by Staphylococcal Products and Allergen Exposure

Special Characteristics of Treatment of Severe Atopic Dermatitis in Children

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