Staphylococcus aureus in Inflammatory Bowel Disease

Chiba, Mitsuro; Hoshina, Sadayori; Kono, Midori; Tobita, M; Fukushima, Tsuneo; Iizuka, Masahiro; Watanabe, So

doi:10.1080/003655201750163079

Cited by 17 publications

(11 citation statements)

References 36 publications

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“…Various studies have reported increased numbers of Staphylococcus spp. in the gut microbiota of active CD patients,5 8 which is similar in infants with inflammatory bowel disease (IBD)27 28 or allergy 29 30. This would suggest there is a relationship between this bacterial group and immune-mediated pathologies.…”

Section: Discussionmentioning

confidence: 99%

IntestinalStaphylococcus spp.and virulent features associated with coeliac disease

et al. 2012

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Section: Discussionmentioning

confidence: 99%

IntestinalStaphylococcus spp.and virulent features associated with coeliac disease

et al. 2012

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“…Intestinal epithelial barrier dysfunction is postulated playing a role in etiology of IBD 48 . Bacteria and their product absorption via compromised epithelial barrier may play an important role in the pathogenesis of IBD or is a predisposing factor of IBD relapses 49 , 50 . Mast cells also play an important role in the pathogenesis of IBD 51 .…”

Section: Discussionmentioning

confidence: 99%

“…48 Bacteria and their product absorption via compromised epithelial barrier may play an important role in the pathogenesis of IBD or is a predisposing factor of IBD relapses. 49,50 Mast cells also play an important role in the pathogenesis of IBD. 51 Pretreatment with anti-tryptase, a key mediator of mast cell, can prevent experimental colitis.…”

Section: Pgn Activates Mast Cells To Compromise T84 Monolayer Barriermentioning

confidence: 99%

Bacterial peptidoglycan breaks down intestinal tolerance via mast cell activation: The role of TLR2 and NOD2

Feng

et al. 2007

Immunol Cell Biol

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Intestinal microbes are believed to be involved in the pathogenesis of inflammatory bowel disease. Microbes and their products are generally well tolerated by intestinal epithelial cells in the intestinal tract of healthy individuals. It is of significance to understand what breaks down the established tolerance leading to intestinal barrier dysfunction and intestinal inflammation. T84 monolayer transported peptidoglycan (PGN) was determined by enzyme-linked immune assay. Mast cell line HMC-1 cell activation in response to PGN stimulation was observed with electron microscopy and measurement of histamine release. T84 monolayer barrier function was determined by recording the transepithelial electric resistance (TER) and measuring the permeability in response to PGN-induced HMC-1 cell activation. Expression of Toll-like receptor (TLR) 2 and nucleotide-binding oligomerization domain (NOD) 2 were determined by immunocytochemistry, real-time reverse transcription (RT)-PCR and Western blot. Exposure to PGN alone did not alter TER and permeability of T84 monolayers. T84 monolayers transported PGN from the apical chamber to the basal chamber of transwell system. TLR2 expressed on the surface of HMC-1 cells. HMC-1 cells absorbed PGN. HMC-1 cells released histamine in response to the PGN stimulation, which was blocked by pretreatment with antibodies or small interfering RNA against TLR2 or NOD2. In a co-culture system, T84 monolayer transported PGN activated HMC-1 cells and increased the horseradish peroxidase flux. TLR2 mediated the PGN-absorption in HMC-1 cells. Blockade of TLR2 or NOD2 abolished PGN-induced HMC-1 cell activation and T84 monolayer barrier dysfunction. T84 monolayer transported PGN activates HMC-1 cells to release chemical mediators to induce T84 monolayer dysfunction that are mediated by TLR2 and NOD2.

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“…is anaerobic Gram-negative coccus of normal human flora that has rarely been identified as a pathogen [37]. Staphylococcus sp., pathogenic aerobic Gram-positive coccus, was isolated in some patients with rheumatoid arthritis [38] and in some studies was reported to be a superantigen in inflammatory bowel disease (IBD), particularly in Crohn's disease [39].…”

Section: Discussionmentioning

confidence: 99%

Commensal intestinal bacterial strains trigger ankylosing enthesopathy of the ankle in inbred B10.BR (H-2k) male mice

Šinkorová

Capková

Niederlova³

et al. 2008

Human Immunology

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Staphylococcus aureus in Inflammatory Bowel Disease

Abstract: Staphylococcal superantigens are not involved in either the early lesions or the established lesions of Crohn disease. However, S. aureus infection occasionally may occur during the course of IBD.

Cited by 17 publications

References 36 publications

IntestinalStaphylococcus spp.and virulent features associated with coeliac disease

IntestinalStaphylococcus spp.and virulent features associated with coeliac disease

Bacterial peptidoglycan breaks down intestinal tolerance via mast cell activation: The role of TLR2 and NOD2

Commensal intestinal bacterial strains trigger ankylosing enthesopathy of the ankle in inbred B10.BR (H-2k) male mice

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