Staphylococcus aureus nasal carriage might be associated with vitamin D receptor polymorphisms in type 1 diabetes

Panierakis, Charalambos; Goulielmos, George N.; Mamoulakis, Dimitrios; Maraki, Sofia; Papavasiliou, E.; Galanakis, Emmanouil

doi:10.1016/j.ijid.2009.02.012

Cited by 34 publications

(29 citation statements)

References 31 publications

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“…To date, there are 65 publications [19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83] on the association of VDR gene SNPs in T1D: these include case-control datasets [20,22,23,25,26,27,28,…”

Section: Vitamin D Pathwaysmentioning

confidence: 99%

Inherited Variation in Vitamin D Genes and Type 1 Diabetes Predisposition

Penna-Martinez

Badenhoop

2017

Genes

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The etiology and pathophysiology of type 1 diabetes remain largely elusive with no established concepts for a causal therapy. Efforts to clarify genetic susceptibility and screening for environmental factors have identified the vitamin D system as a contributory pathway that is potentially correctable. This review aims at compiling all genetic studies addressing the vitamin D system in type 1 diabetes. Herein, association studies with case control cohorts are presented as well as family investigations with transmission tests, meta-analyses and intervention trials. Additionally, rare examples of inborn errors of vitamin D metabolism manifesting with type 1 diabetes and their immune status are discussed. We find a majority of association studies confirming a predisposing role for vitamin D receptor (VDR) polymorphisms and those of the vitamin D metabolism, particularly the CYP27B1 gene encoding the main enzyme for vitamin D activation. Associations, however, are tenuous in relation to the ethnic background of the studied populations. Intervention trials identify the specific requirements of adequate vitamin D doses to achieve vitamin D sufficiency. Preliminary evidence suggests that doses may need to be individualized in order to achieve target effects due to pharmacogenomic variation.

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Section: Vitamin D Pathwaysmentioning

confidence: 99%

Inherited Variation in Vitamin D Genes and Type 1 Diabetes Predisposition

Penna-Martinez

Badenhoop

2017

Genes

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“…103 Similar findings suggest that VDR polymorphisms may be associated with nasal carriage of S. aureus in individuals with type 1 diabetes mellitus. 104 However, others found no association between VDR gene variation and S. aureus nasal carriage. 105 Moreover, vitamin D deficiency has been linked to adverse and more costly outcomes in veterans with Clostridium difficile and methicillin-sensitive S. aureus infections.…”

Section: Antimicrobial Efficacy Against Different Infective Agentsmentioning

confidence: 99%

Antimicrobial implications of vitamin D

Youssef

Miller

Elabbassi

et al. 2011

Dermato-Endocrinology

171

128

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“…aureus konnte ein Polymorphismus des Vitamin D Rezeptors bei Typ 1 Diabetes-Patienten nachgewiesen werden [204] . Gleichzeitig ist die Konzentration des bakterioziden, nasalen NO bei insulinabh ä ngigen Diabetikern vermindert [166] .…”

Section: Einfl Uss Von Diabetes Mellitus Auf Die Respiratorische Funkunclassified

Funktionen und Funktionsstörungen der respiratorischen Schleimhaut der Nase und der Nasennebenhöhlen

Beule¹

2010

Laryngo-Rhino-Otol

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In this review, anatomy and physiology of the respiratory mucosa of nose and paranasal sinuses are summarized under the aspect of its clinical significance. Basics of endonasal cleaning including mucociliary clearance and nasal reflexes, as well as defence mechanisms are explained. Physiological wound healing, aspects of endonasal topical medical therapy and typical diagnostic procedures to evaluate the respiratory functions are presented. Finally, the pathophysiologies of different subtypes of non-allergic rhinitis are outlined together with treatment recommendations.

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Staphylococcus aureus nasal carriage might be associated with vitamin D receptor polymorphisms in type 1 diabetes

Abstract: Our findings suggest that VDR polymorphisms may be associated with nasal carriage of S. aureus in individuals with T1D, and further contribute to the better understanding of the immunomodulatory role of vitamin D in the human host's response and susceptibility to infection.

Cited by 34 publications

References 31 publications

Inherited Variation in Vitamin D Genes and Type 1 Diabetes Predisposition

Inherited Variation in Vitamin D Genes and Type 1 Diabetes Predisposition

Antimicrobial implications of vitamin D

Funktionen und Funktionsstörungen der respiratorischen Schleimhaut der Nase und der Nasennebenhöhlen

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