Staphylococcus aureus sensible a meticilina, productor de leucocidina de Panton Valentine. A propósito de dos casos pediátricos de infección osteoarticular

Zúñiga, Marcela; Passalacqua, Stephanía; Benadof, Dona; Conca, Natalia; Acuña, Mirta

doi:10.4067/s0716-10182021000200300

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“…While some regions have seen a decline in MRSA infections, others have identified specific clones that have predominated. This can be influenced by a combination of factors such as infection prevention strategies (which have been effective in reducing hospital onset infections and transmission), changes in treatment principles, variations in virulence and genetic diversity, and differences in the types of infections captured (invasive vs. non-invasive, or community vs. hospital-acquired) ( 4 , 9 , 34 , 35 ). Despite the prevalence of MSSA, the reasons behind the lack of a notable decline in MRSA frequency—a finding that contradicts existing literature—within the studied cities remain unclear.…”

Section: Discussionmentioning

confidence: 99%

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Epidemiological and microbiological characteristics of S. aureus pediatric infections in Colombia 2018–2021, a national multicenter study (Staphylored Colombia)

Gutierrez-Tobar,

Carvajal,

Vasquez-Hoyos

et al. 2024

Front. Pediatr.

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BackgroundStaphylococcus aureus infections are a significant cause of morbidity and mortality in pediatric populations worldwide. The Staphylo Research Network conducted an extensive study on pediatric patients across Colombia from 2018 to 2021. The aim of this study was to describe the epidemiological and microbiological characteristics of S. aureus in this patient group.MethodsWe analyzed S. aureus isolates from WHONET-reporting centers. An “event” was a positive culture isolation in a previously negative individual after 2 weeks. We studied center characteristics, age distribution, infection type, and antibiotic susceptibilities, comparing methicillin sensitive (MSSA) and resistant S. aureus (MRSA) isolates.ResultsIsolates from 20 centers across 7 Colombian cities were included. Most centers (80%) served both adults and children, with 55% offering oncology services and 85% having a PICU. We registered 8,157 S. aureus culture isolations from 5,384 events (3,345 MSSA and 1,961 MRSA) in 4,821 patients, with a median age of 5 years. Blood (26.2%) and skin/soft tissue (18.6%) were the most common infection sources. Most isolates per event remained susceptible to oxacillin (63.2%), clindamycin (94.3%), and TMP-SMX (98.3%). MRSA prevalence varied by city (<0.001), with slightly higher rates observed in exclusively pediatric hospitals. In contrast, the MRSA rate was somewhat lower in centers with Antimicrobial Stewardship Program (ASP). MRSA was predominantly isolated from osteoarticular infections and multiple foci, while MSSA was more frequently associated with recurrent infections compared to MRSA.ConclusionsThis is the largest study of pediatric S. aureus infections in Colombia. We found MSSA predominance, but resistance have important regional variations. S. aureus remains susceptible to other commonly used antibiotics such as TMP-SMX and clindamycin. Ongoing monitoring of S. aureus infections is vital for understanding their behavior in children. Prospective studies within the Staphylored LATAM are underway for a more comprehensive clinical and genetic characterization.

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Section: Discussionmentioning

confidence: 99%

“…A future Staphylored LATAM, Colombia project will prospectively evaluate these factors. Further research is also needed to explore associations between severe S. aureus isolates, recurrence, and virulence mechanisms like PVL and enterotoxins, often observed in MRSA ( 35 ).…”

Section: Discussionmentioning

confidence: 99%