Stapleless vs Stapled Gastric Bypass vs Hypocaloric Diet: a Three-Arm Randomized Controlled Trial of Body Mass Evolution with Secondary Outcomes for Telomere Length and Metabolic Syndrome Changes

Ospanov, Oral; Akilzhanova, Ainur; Buchwald, J. N.; Fursov, Alexandr; Bekmurzinova, Farida; Rakhimova, Saule; Yeleuov, Galymzhan; Kozhamkulov, Ulan; Abdina, Zhanar; Fursov, Roman; Jumayeva, Lyudmila

doi:10.1007/s11695-021-05454-2

Cited by 6 publications

(4 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, bariatric surgery has been marked as a protective factor against COVID-19 with lower hospital admission rate, reduced intensive care unit admission [ 24 ], mechanical ventilation, or exitus [ 25 ]. Considering the improvement on obesity comorbidities, all bariatric procedures cancelled or delayed during the COVID-19 pandemic should be restarted as soon as possible [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of the COVID-19 Pandemic and Lockdown on Gastric Bypass Results at 1-Year Follow-up

et al. 2021

View full text Add to dashboard Cite

Purpose The COVID-19 pandemic caused a lockdown in many countries, which induced negative dietary habits and sedentary behavior. Studies suggest that weight loss of patients undergoing bariatric surgery was equally affected. The aim was to evaluate the impact of COVID-19 on weight loss, obesity-related comorbidities, and nutritional status at 1-year follow-up after gastric bypass (GB). Methods Retrospective observational case–control study of patients undergoing primary GB in a tertiary referral Belgian center. COVID-19 period group was composed by those whose 1-year postoperative period was affected by the COVID-19 pandemic and lockdown: from October 1, 2019, to March 31, 2020. The control group was composed of patients operated from October 1, 2018, to March 31, 2019. Electronic clinical records were reviewed searching: baseline characteristics, weight and comorbidities evolution, and biochemical values. Results A total of 47 patients in the COVID-19 period group and 66 in the non-COVID-19 period group were analyzed. There were no significant differences in baseline characteristics. A reduced weight loss was observed at 1-year follow-up, in terms of percentage of excess weight loss (%EWL) (82.4% [SD: 21.6] vs. 82.4% [SD: 21.6]; p : 0.043) and body mass index (BMI) (27.8 kg/m 2 [IQR: 25.8–30.0] vs. 26.2 kg/m 2 [IQR: 24.6–28.6]; p : 0.029) for COVID-19 period group vs. non-COVID-19 period group, respectively. There was a similar reduction of obesity-related comorbidities, without clinically significant differences in the nutritional follow-up. Conclusion The COVID-19 pandemic and lockdown had an impact on weight loss at 1-year follow-up after gastric bypass. Graphical abstract

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of the COVID-19 Pandemic and Lockdown on Gastric Bypass Results at 1-Year Follow-up

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Telomere shortening can accelerate cellular aging and impair function, fueling atherosclerosis and other vascular diseases [ 30 ]. Studies indicate that weight loss surgery and calorie restriction can decrease BMI and increase telomere length in MetS patients, providing insights for managing their health [ 32 ]. However, a few studies indicate that short telomere burden and average LTL are not robust independent predictors of atherosclerosis at the preclinical stage [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

17-year follow-up of association between telomere length and all-cause mortality, cardiovascular mortality in individuals with metabolic syndrome: results from the NHANES database prospective cohort study

Xiong,

Yang,

Guo

et al. 2023

Diabetol Metab Syndr

View full text Add to dashboard Cite

Background The relationship between leukocyte telomere length (LTL) and mortality risk in individuals with metabolic syndrome (MetS) remains poorly understood. This study aimed to investigate the association between telomere length and long-term all-cause mortality, and cardiovascular disease (CVD) mortality, in individuals with MetS in the United States. Methods A total of 1980 participants with MetS aged 18 years or older from the National Health and Nutrition Examination Survey (NHANES) prospective cohort study (1999–2002) were included in this cohort study. Medical records review was used to identify the cause of deaths as of December 2018. We employed Kaplan-Meier curves, fitted curves, and Cox proportional hazards regression models to estimate hazard ratios (HRs) for all-cause and CVD mortality, stratified by tertiles of LTL. Results Over a median follow-up of 17.75 years of participants with metabolic syndrome, 819 deaths occurred, including 231 cardiovascular deaths. After adjusting for multiple covariates, participants with shorter telomere length had a significantly higher risk of all-cause mortality (HR, 1.33; 95% CI, 1.11–1.6) and CVD mortality (HR, 1.36; 95% CI, 0.96–1.93) compared with those in the highest tertile of telomere length. All-cause mortality (P < 0.001) and cardiovascular disease mortality (P = 0.028) followed a similar pattern across tertiles of telomere length. Conclusion In individuals with MetS, shorter telomere length is associated with increased risks of death from cardiovascular disease and all causes. The underlying mechanisms and clinical implications of these findings require additional investigation.

show abstract

“…Various bariatric interventions such as hypocaloric diet therapy and gastric bypass are being used for the management of obesity. Compared to the hypocaloric diet therapy, gastric bypass resulted in greater body mass loss and greater metabolic syndrome resolution, but none of these interventions have an anti-reflux component, such as a fundoplication [7] .…”

Section: Discussionmentioning

confidence: 99%

One anastomosis gastric bypass with fundoplication of remnant stomach for weight regain prevention: Case report

Ospanov

Nadirov

Koikov

et al. 2022

International Journal of Surgery Case Reports

View full text Add to dashboard Cite

Stapleless vs Stapled Gastric Bypass vs Hypocaloric Diet: a Three-Arm Randomized Controlled Trial of Body Mass Evolution with Secondary Outcomes for Telomere Length and Metabolic Syndrome Changes

Cited by 6 publications

References 38 publications

Impact of the COVID-19 Pandemic and Lockdown on Gastric Bypass Results at 1-Year Follow-up

Impact of the COVID-19 Pandemic and Lockdown on Gastric Bypass Results at 1-Year Follow-up

17-year follow-up of association between telomere length and all-cause mortality, cardiovascular mortality in individuals with metabolic syndrome: results from the NHANES database prospective cohort study

One anastomosis gastric bypass with fundoplication of remnant stomach for weight regain prevention: Case report

Contact Info

Product

Resources

About