Star‐shaped alkylated poly(glycerol methacrylate) reverse micelles: Synthesis and evaluation of their solubilizing properties in dichloromethane

Gao, Hui; Jones, Marie‐Christine; Tewari, Pankaj Kumar; Ranger, Maxime; Leroux, Jean‐Christophe

doi:10.1002/pola.22004

Cited by 43 publications

(51 citation statements)

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“…A related synthetic approach presented by Leroux and coworkers. [183][184][185] involves the formation of reversed micelles by ATRP. Four-, 5-, 6-, and 8-arm ATRP initiators were prepared and used to polymerize glycidylmethacrylate.…”

Section: Non-aqueous Encapsulation Systemsmentioning

confidence: 99%

Dendritic Polyglycerols for Biomedical Applications

et al. 2009

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The application of nanotechnology in medicine and pharmaceuticals is a rapidly advancing field that is quickly gaining acceptance and recognition as an independent area of research called "nanomedicine". Urgent needs in this field, however, are biocompatible and bioactive materials for antifouling surfaces and nanoparticles for drug delivery. Therefore, extensive attention has been given to the design and development of new macromolecular structures. Among the various polymeric architectures, dendritic ("treelike") polymers have experienced an exponential development due to their highly branched, multifunctional, and well-defined structures. This Review describes the diverse syntheses and biomedical applications of dendritic polyglycerols (PGs). These polymers exhibit good chemical stability and inertness under biological conditions and are highly biocompatible. Oligoglycerols and their fatty acid esters are FDA-approved and are already being used in a variety of consumer applications, e.g., cosmetics and toiletries, food industries, cleaning and softening agents, pharmaceuticals, polymers and polymer additives, printing photographing materials, and electronics. Herein, we present the current status of dendritic PGs as functional dendritic architectures with particular focus on their application in nanomedicine, in drug, dye, and gene delivery, as well as in regenerative medicine in the form of non-fouling surfaces and matrix materials.

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Section: Non-aqueous Encapsulation Systemsmentioning

confidence: 99%

Dendritic Polyglycerols for Biomedical Applications

et al. 2009

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“…Methylethylamine (MEA), diethylamine (DEA), and DPA were obtained from Tianjin Guangfu Synthesis of amino poly(glycerol methacrylate)s and quaternized poly(glycidyl methacrylate)s Linear (L-PGMA) and 8-arm (S8-PGMA) PGMAs were synthesized and modified with different amines according to our previous reports. [33,34] Briefly, GMA was polymerized in THF using the corresponding atom transfer radical polymerization initiator to yield L-PGMA and S8-PGMA products. The L-PGMA and S8-PGMA were then modified with three kinds of aliphatic amines, i.e.…”

Section: Experimental Materialsmentioning

confidence: 99%

Antimicrobial activities of polymeric quaternary ammonium salts from poly(glycidyl methacrylate)s

Liang

Zhu

Yang

et al. 2013

Polymers for Advanced Techs

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Amino poly(glycerol methacrylate)s (PGOHMAs) were synthesized from linear and 8-arm poly(glycidyl methacrylate)s (PGMAs) via ring opening reactions with methylethylamine (MEA), diethylamine, and dipropylamine, respectively, which were further modified by quaternization reaction using methyl iodide to obtain quaternized PGMAs (QPGMAs for short). The products were characterized by Fourier transform infrared spectroscopy, proton nuclear magnetic resonance, gel permeation chromatography, and thermogravimetric analysis. The amination percentage of amino PGOHMAs and the degree of quaternization of QPGMAs were calculated by elemental analysis and X-ray photoelectron spectroscopy, respectively. According to the solubility test results, 8-arm PGOHMA modified with MEA (S8-MEA) is the only water-soluble derivative of amino PGOHMAs and was employed as a positive control for the comparison with QPGMAs. Antimicrobial studies on these PGMA derivatives were carried out by testing the minimum inhibitory concentration and the bacteria inhibitive rate against Escherichia coli and Staphylococcus aureus. The results indicated that QPGMAs possessed higher antimicrobial activity than S8-MEA and exhibited increased antimicrobial activity against both bacteria with an increased degree of quaternization in weak basic conditions. Moreover, the chemical structure of PGMA derivatives and pH value of the assay conditions were found to affect the antimicrobial activity.

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“…From this latter technique, an analysis was made in terms of sequence distribution and stereoregularity of monomer units along the macromolecular chains of P(G-co-B) copolymers, demonstrating that the system under study presents the features of spontaneous gradient copolymers. Besides, the polymeric systems based on G present a high synthetic potential, so for example they can be easily hydrolyzed to yield the new hydroxylated derivatives (amphiphilic systems), as the recent literature has well described [38].…”

Section: Introductionmentioning

confidence: 98%