2024
DOI: 10.1038/s41375-024-02369-6
|View full text |Cite
|
Sign up to set email alerts
|

Star wars against leukemia: attacking the clones

Monika M. Toma,
Tomasz Skorski

Abstract: Leukemia, although most likely starts as a monoclonal genetic/epigenetic anomaly, is a polyclonal disease at manifestation. This polyclonal nature results from ongoing evolutionary changes in the genome/epigenome of leukemia cells to promote their survival and proliferation advantages. We discuss here how genetic and/or epigenetic aberrations alter intracellular microenvironment in individual leukemia clones and how extracellular microenvironment selects the best fitted clones. This dynamic polyclonal composit… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 166 publications
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?