Starch-based biodegradable hydrogels with potential biomedical applications as drug delivery systems

One limitation associated with the delivery of bioactive agents concerns the short half-life of these molecules when administered intravenously, which results in their loss from the desired site. Incorporation of bioactive agents into depot vehicles provides a means to increase their persistence at the disease site. Major issues are involved in the development of a proper carrier system able to deliver the correct drug, at the desired dose, place and time. In this work, starch-poly-e-caprolactone (SPCL) microparticles were developed for use in drug delivery and tissue engineering (TE) applications. SPCL microparticles were prepared by using an emulsion solvent extraction/evaporation technique, which was demonstrated to be a successful procedure to obtain particles with a spherical shape (particle size between 5 and 900 lm) and exhibiting different surface morphologies. Their chemical structure was confirmed by Fourier transform infrared spectroscopy. To evaluate the potential of the developed microparticles as a drug delivery system, dexamethasone (DEX) was used as model drug. DEX, a well-known component of osteogenic differentiation media, was entrapped into SPCL microparticles at different percentages up to 93%. The encapsulation efficiency was found to be dependent on the polymer concentration and drug-to-polymer ratio. The initial DEX release seems to be governed mainly by diffusion, and it is expected that the remaining DEX will be released when the polymeric matrix starts to degrade. In this work it was demonstrated that SPCL microparticles containing DEX can be successfully prepared and that these microparticular systems seem to be quite promising for controlled release applications, namely as carriers of important differentiation agents in TE.

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“…Materials of natural origin have been studied and proposed for a wide range of biomedical applications [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of starch-poly-ε-caprolactone microparticles incorporating bioactive agents for drug delivery and tissue engineering applications

et al. 2009

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“…[1][2][3][4] Since, the introduction of hydrogels as novel materials possibly suitable for a broad spectrum of biomedical applications, their research has become a fast-developing and exciting research field. [5][6][7] Over past decade, a number of applications involving stimuli-sensitive hydrogels have arisen tremendously due to the great potential for intelligent materials as matrices, actuators and transducers.…”

Section: Introductionmentioning

confidence: 99%

“…These hydrogels were treated first with AgNO3 then, subsequently with NaBH 4 solutions as explained in the experimental section. The equilibrium swelling capacity or swelling ratio (Q) of the hydrogel was calculated employing the following equation (1).…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Characterization, and Antibacterial Applications of Novel Copolymeric Silver Nanocomposite Hydrogels

Kim¹,

Babu²,

Thangadurai³

et al. 2011

Bulletin of the Korean Chemical Society

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Copolymeric silver nanocomposite hydrogels were synthesized by using acryloyl phenylalanine (APA), N'-isopropylacrylamide (NIPAM) and crosslinked by N,N-methylene bisacrylamide (MBA) via radical redox polymerization. Present study allows entrapping silver nanoparticles into hydrogel networks. UV-visible spectroscopy and X-ray diffraction (XRD) studies confirmed the formation of silver nanoparticles in hydrogel matrix. 11% of weight loss difference between hydrogel and silver nanocomposite hydrogel is clearly indicates the formation and silver nanoparticles by thermo-gravimetrical analysis. The order of swelling capacity values of hydrogels and silver nanocmposite hydrogels were found to be in the order of placebo copolymeric hydrogel >Ag-copolymeric silver nanocomposite hydrogels. The particle size of silver nanoparticles was analysed and are in the range of 5 -10 nm which has been confirmed by transmission electron microscopy (TEM) as well as particle size analysis. The silver nanocomposite hydrogel has shown very good antibacterial activity on gram-positive and gram-negative bacteriocides.

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“…1 Starch-based polymers have been studied mainly by Reis et al [2][3][4][5] for a wide range of bonerelated applications, ranging from tissue engineering scaffolds, 6 -11 to bone cements, [12][13][14] and drug delivery systems. 14 -16 These materials display a set of features that support their potential in the biomedical field, such as natural origin, good mechanical properties, 3,11,[17][18][19] good biological performance, 20 -25 and the possibility of tailoring their properties 26 -29 according to the foreseen application.…”

Section: Introductionmentioning

confidence: 99%

Entrapment ability and release profile of corticosteroids from starch‐based microparticles

Silva

Costa

Neves

et al. 2005

J Biomedical Materials Res

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Abstract:We previously described the synthesis of starchbased microparticles that were shown to be bioactive (when combined with Bioactive Glass 45S5) and noncytotoxic. To further assess their potential for biomedical applications such as controlled release, three corticosteroids with a similar basic structure-dexamethasone (DEX), 16␣-methylprednisonole (MP), and 16␣-methylprednisolone acetate (MPA)-were used as models for the entrapment and release of bioactive agents. DEX, MP, and MPA were entrapped into starch-based microparticles at 10% wt/wt of the starch-based polymer and the loading efficiencies, as well as the release profiles, were evaluated. Differences were found for the loading efficiencies of the three corticosteroids, with DEX and MPA being the most successfully loaded (82 and 84%, respectively), followed by MP (51%). These differences might be explained based on the differential distribution of the molecules within the matrix of the microparticles. Furthermore, a differential burst release was observed in the first 24 h for all corticosteroids with DEX and MP being more pronounced (around 25%), whereas only 12% of MPA was released during the same time period. Whereas the water uptake profile can account for this first stage burst release, the subsequent slower release stage was mainly attributed to degradation of the microparticle network. Differences in the release profiles can be explained based on the structure of the molecule, because MPA, a more bulky and hydrophobic molecule, is released at a slower rate compared with DEX and MP. In this work, it is shown that these carriers were able to sustain a controlled release of the entrapped corticosteroids over 30 days, which confirms the potential of these systems to be used as carriers for the delivery of bioactive agents.

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Starch-based biodegradable hydrogels with potential biomedical applications as drug delivery systems

Cited by 316 publications

References 22 publications

Preparation and characterization of starch-poly-ε-caprolactone microparticles incorporating bioactive agents for drug delivery and tissue engineering applications

Preparation and characterization of starch-poly-ε-caprolactone microparticles incorporating bioactive agents for drug delivery and tissue engineering applications

Synthesis, Characterization, and Antibacterial Applications of Novel Copolymeric Silver Nanocomposite Hydrogels

Entrapment ability and release profile of corticosteroids from starch‐based microparticles

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