Starch Coated Silver Nanoparticles Using Hygrophila Auriculata L for Controlled Released of Ofloxacin

Abstract

Abstract:In this study, we developed encapsulating Ofloxacin (OFL) drug loaded starch coated Hygrophila auriculata L mediated silver nanoparticles (H-AgNPs) [Ofloxacin loaded starch coated-H-AgNPs]. HAgNPs were characterized by UV-Visible spectrophotometer, XRD, TEM. The OFL-loaded starch coated-H-AgNPs was evaluated by particle size, surface charge, entrapment efficacy, and effect of pH in drug release profile. Additionally, drug entrapment efficacy (EE) was up to 43%; OFL -starch-H-AgNPs showed a pH-responsive drug release in vitro. The OFL release was nearly 79% at pH 4.5 and 68% at pH 7.4.The current work proves the potential of pharmacology that involves a fusion of advanced techniques from nanoscience to develop the biology and used in the fields of drug delivery.