Starch Phosphate Microgels for Controlled Release of Biomacromolecules

Yurkshtovich, T. L.; Голуб, Н. В.; Yurkshtovich, N. K.; Бычковский, П. М.; Костерова, Р. И.; Alinovskaya, V. A.

doi:10.1134/s0003683817080087

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…These microgels were constructed using dextrin, which contains amylose sugar in its structure that can be degraded with time by amylase enzyme present in soil. 64 PDXE MGs showed excellent loading (∼10%) and encapsulation efficiency (∼88%) for urea fertilizer. Hydrophobic modification of dextrin by lauroyl chains reduced the release rate of urea (90% within ∼24 days) in water.…”

Section: Discussionmentioning

confidence: 98%

“…Here, we developed biodegradable PDXE MGs for slow delivery of urea and a source of P in the agricultural field. These microgels were constructed using dextrin, which contains amylose sugar in its structure that can be degraded with time by amylase enzyme present in soil . PDXE MGs showed excellent loading (∼10%) and encapsulation efficiency (∼88%) for urea fertilizer.…”

Section: Discussionmentioning

confidence: 99%

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Biodegradable Dextrin-Based Microgels for Slow Release of Dual Fertilizers for Sustainable Agriculture

Dhiman,

Thaper,

Bhardwaj

et al. 2024

ACS Appl. Mater. Interfaces

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In this research, we report dextrin-based biodegradable microgels (PDXE MGs) having phosphate-based cross-linking units for slow release of urea and a potential P source to improve fertilization. PDXE MGs (∼200 nm) are synthesized by crosslinking the lauroyl-functionalized dextrin chains with sodium tripolyphosphate. The developed PDXE MGs exhibit high loading (∼10%) and encapsulation efficiency (∼88%) for urea. It is observed that functionalization of PDXE MGs with lauroyl chains slows down the release of urea (90% in ∼24 days) as compared to nonfunctionalized microgels (PDX MGs) (99% in ∼17 days) in water. Further studies of the developed formulation display that Urea@PDXE MGs significantly boost maize seed germination and overall plant growth as compared to pure urea fertilizer. Moreover, analysis of maize leaves obtained from plants treated with Urea@PDXE MGs reveals 3.5 ± 0.3% nitrogen content and 90 ± 0.7 mg/ g chlorophyll content. These values are significantly higher than 1.4 ± 0.6% nitrogen content and 48 ± 0.05 mg/g chlorophyll content obtained by using bare urea. Further, acid phosphatase activity in roots is reduced upon treatment with PDXE MGs and Urea@PDXE MGs, suggesting the availability of P upon degradation of PDXE MGs by the amylase enzyme in soil. These experimental results present the developed microgel-based biodegradable formulation with a slow release feature as a potential candidate to move toward sustainable agriculture practices.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Biodegradable Dextrin-Based Microgels for Slow Release of Dual Fertilizers for Sustainable Agriculture

Dhiman,

Thaper,

Bhardwaj

et al. 2024

ACS Appl. Mater. Interfaces

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“…The study reported that the novel microgels successfully sustained the release of sodium benzoate and zosteric acid for up to 72 and 120 h, respectively [56]. Yurkshtovich et al demonstrated the ability of starch phosphate microgels to encapsulate interferon-alpha 2b and aimed to deliver the therapeutic agent for cancer or viral infection treatments [57]. Furthermore, Zhang et al developed the self-stabilized hyaluronic acid nanogels for the codelivery of doxorubicin and cisplatin to treat osteosarcoma.…”

Section: Use Of Microgels or Nanogels As Drug Delivery Systemsmentioning

confidence: 99%

Development of a Polysaccharide-Based Hydrogel Drug Delivery System (DDS): An Update

Pushpamalar

Meganathan

Tan

et al. 2021

Gels

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Delivering a drug to the target site with minimal-to-no off-target cytotoxicity is the major determinant for the success of disease therapy. While the therapeutic efficacy and cytotoxicity of the drug play the main roles, the use of a suitable drug delivery system (DDS) is important to protect the drug along the administration route and release it at the desired target site. Polysaccharides have been extensively studied as a biomaterial for DDS development due to their high biocompatibility. More usefully, polysaccharides can be crosslinked with various molecules such as micro/nanoparticles and hydrogels to form a modified DDS. According to IUPAC, hydrogel is defined as the structure and processing of sols, gels, networks and inorganic–organic hybrids. This 3D network which often consists of a hydrophilic polymer can drastically improve the physical and chemical properties of DDS to increase the biodegradability and bioavailability of the carrier drugs. The advancement of nanotechnology also allows the construction of hydrogel DDS with enhanced functionalities such as stimuli-responsiveness, target specificity, sustained drug release, and therapeutic efficacy. This review provides a current update on the use of hydrogel DDS derived from polysaccharide-based materials in delivering various therapeutic molecules and drugs. We also highlighted the factors that affect the efficacy of these DDS and the current challenges of developing them for clinical use.

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Effect of the Composition of an Esterification Mixture on the Acid Properties of Gel-Forming Phosphorylated Polysaccharides

Yurkshtovich

Голуб

Solomevich

et al. 2019

Russ. J. Phys. Chem.

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Starch Phosphate Microgels for Controlled Release of Biomacromolecules

Cited by 3 publications

References 11 publications

Biodegradable Dextrin-Based Microgels for Slow Release of Dual Fertilizers for Sustainable Agriculture

Biodegradable Dextrin-Based Microgels for Slow Release of Dual Fertilizers for Sustainable Agriculture

Development of a Polysaccharide-Based Hydrogel Drug Delivery System (DDS): An Update

Effect of the Composition of an Esterification Mixture on the Acid Properties of Gel-Forming Phosphorylated Polysaccharides

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