STAT3 inactivation suppresses stemness properties in gastric cancer stem cells and promotes Th17 in Treg/Th17 balance

Hajimoradi, Monireh; Rezalotfi, Alaleh; Esmaeilnejad-Ahranjani, Parvaneh; Hassan, Zuhair Mohammad; Ebrahimi, Marzieh

doi:10.1016/j.intimp.2022.109048

Cited by 11 publications

(8 citation statements)

References 54 publications

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“…Following differentiation, TH17 cells cause further neutrophil activation, creating a positive feedback loop [ 153 ]. Given that Th17 T cells are associated with cancer progression [ 154 , 155 , 156 ], we could hypothesize that histones exert a direct effect on tumorigenesis.…”

Section: Circulating Histones In Solid Cancers: Detection Monitoring ...mentioning

confidence: 99%

Circulating Histones to Detect and Monitor the Progression of Cancer

Tsoneva

Ivanov

Conev

et al. 2023

IJMS

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Liquid biopsies have emerged as a minimally invasive cancer detection and monitoring method, which could identify cancer-related alterations in nucleosome or histone levels and modifications in blood, saliva, and urine. Histones, the core component of the nucleosome, are essential for chromatin compaction and gene expression modulation. Increasing evidence suggests that circulating histones and histone complexes, originating from cell death or immune cell activation, could act as promising biomarkers for cancer detection and management. In this review, we provide an overview of circulating histones as a powerful liquid biopsy approach and methods for their detection. We highlight current knowledge on circulating histones in hematologic malignancies and solid cancer, with a focus on their role in cancer dissemination, monitoring, and tumorigenesis. Last, we describe recently developed strategies to identify cancer tissue-of-origin in blood plasma based on nucleosome positioning, inferred from nucleosomal DNA fragmentation footprint, which is independent of the genetic landscape.

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Section: Circulating Histones In Solid Cancers: Detection Monitoring ...mentioning

confidence: 99%

Circulating Histones to Detect and Monitor the Progression of Cancer

Tsoneva

Ivanov

Conev

et al. 2023

IJMS

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“…TGF has also been long recognized as important for the tumorigenic process, leading groups to develop new 3D culture systems in order to better understand how this cytokine interacts within the tumor microenvironment. Free floating spheroids were prepared from the human gastric cancer line MKN-45, which were then used to study the role of STAT3 activation [ 145 ]. These spheroid cultures presented higher STAT3 activity, up-regulation of TGF-β and VEGF with downregulation of IL-6.…”

Section: Modeling the Tumor Microenvironment In Vitromentioning

confidence: 99%

Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool

Rodrigues,

Reis,

Pirraco

2024

J Biomed Sci

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Cancer remains a serious burden in society and while the pace in the development of novel and more effective therapeutics is increasing, testing platforms that faithfully mimic the tumor microenvironment are lacking. With a clear shift from animal models to more complex in vitro 3D systems, spheroids emerge as strong options in this regard. Years of development have allowed spheroid-based models to better reproduce the biomechanical cues that are observed in the tumor-associated extracellular matrix (ECM) and cellular interactions that occur in both a cell–cell and cell-ECM manner. Here, we summarize some of the key cellular interactions that drive tumor development, progression and invasion, and how successfully are these interactions recapitulated in 3D spheroid models currently in use in the field. We finish by speculating on future advancements in the field and on how these can shape the relevance of spherical 3D models for tumor modelling.

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“… 30 Th17 differentiation in vivo is also influenced by the balance between Th17 and Treg cells. 212 – 214 In patients with SLE, Treg cells decrease and Th17 cells increase. This Th17/Treg imbalance promotes lupus severity.…”

Section: Il-17 Involvement In Pathologic Responsesmentioning

confidence: 99%

The IL-17 family in diseases: from bench to bedside

Huangfu,

Li,

Huang

et al. 2023

Sig Transduct Target Ther

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The interleukin-17 (IL-17) family comprises six members (IL-17A–17F), and recently, all of its related receptors have been discovered. IL-17 was first discovered approximately 30 years ago. Members of this family have various biological functions, including driving an inflammatory cascade during infections and autoimmune diseases, as well as boosting protective immunity against various pathogens. IL-17 is a highly versatile proinflammatory cytokine necessary for vital processes including host immune defenses, tissue repair, inflammatory disease pathogenesis, and cancer progression. However, how IL-17 performs these functions remains controversial. The multifunctional properties of IL-17 have attracted research interest, and emerging data have gradually improved our understanding of the IL-17 signaling pathway. However, a comprehensive review is required to understand its role in both host defense functions and pathogenesis in the body. This review can aid researchers in better understanding the mechanisms underlying IL-17’s roles in vivo and provide a theoretical basis for future studies aiming to regulate IL-17 expression and function. This review discusses recent progress in understanding the IL-17 signaling pathway and its physiological roles. In addition, we present the mechanism underlying IL-17’s role in various pathologies, particularly, in IL-17-induced systemic lupus erythematosus and IL-17-related tumor cell transformation and metastasis. In addition, we have briefly discussed promising developments in the diagnosis and treatment of autoimmune diseases and tumors.

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STAT3 inactivation suppresses stemness properties in gastric cancer stem cells and promotes Th17 in Treg/Th17 balance

Cited by 11 publications

References 54 publications

Circulating Histones to Detect and Monitor the Progression of Cancer

Circulating Histones to Detect and Monitor the Progression of Cancer

Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool

The IL-17 family in diseases: from bench to bedside

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