STAT3 Partly Inhibits Cell Proliferation via Direct Negative Regulation of FST Gene Expression

Xu, Haidong; Ma, Guangwei; Mu, Fang; Ning, Bolin; Li, Hui; Wang, Ning

doi:10.3389/fgene.2021.678667

Cited by 3 publications

(3 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Homozygous mouse lacking INHBA show dysfunctional beard, palate, and tooth development [ 50 ]. FST overexpression in sheep remarkably promotes the proliferation of sheep fetal fibroblasts and human keratinocytes [ 51 ]. In summary, the increased expression of TNF , MAP2K2 , INHBA , and FST may have a positive effect on wool growth and wool density.…”

Section: Discussionmentioning

confidence: 99%

Identification of key genes and signaling pathways related to Hetian sheep wool density by RNA-seq technology

Shi

Liu

et al. 2022

PLoS ONE

View full text Add to dashboard Cite

Hetian sheep is a breed of sheep unique to the Hetian area of Xinjiang whose wool is used for producing blankets. Individual differences and hair follicle density are the key factors affecting wool production. Therefore, this study aimed to assess the Hetian sheep having different wool densities to statistically analyze the wool traits and hair follicle parameters. Furthermore, the transcriptome sequencing analysis was performed on the skins with different wool densities. The results showed that wool quantity and total hair follicle density of the high wool density sheep was significantly higher than low wool density sheep. The sheepskin with high wool density was found to grow more and finer wool than sheepskin with low wool density. A total of 1,452 differentially expressed genes were screened from the two sets of samples, including 754 upregulated and 698 downregulated genes. The differentially expressed genes were involved in the TGF-β/BMP and MAPK signaling pathways related to hair growth. Eleven differentially expressed genes belonging to the KAPs and KIFs might affect the fineness of the wool. The key genes, like the TNF, MAP2K2, INHBA, FST, PTPN11, MAP3K7, KIT, and BMPR1A, were found to probably affect the growth and density of the wool. The qPCR verified eight genes related to the MAPK pathway whose gene expression trends were consistent with the transcriptome sequencing results. This study furnishes valuable resources for enhancing the quality and production of wool in the Hetian sheep.

show abstract

Section: Discussionmentioning

confidence: 99%

Identification of key genes and signaling pathways related to Hetian sheep wool density by RNA-seq technology

Shi

Liu

et al. 2022

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Table S11. Additional studies on the curly fleece phenotype in sheep [132,146,[328][329][330][331][332][333][334][335][336][337][338][339][340][341][342][343][344][345][346]. Table S12.…”

Section: Supplementary Informationmentioning

confidence: 99%

“…Table S12. Additional studies of the fine vs. coarse fleece phenotype in sheep [138,333,334,[347][348][349][350][351][352][353][354][355][356][357][358]. Table S13.…”

Section: Supplementary Informationmentioning

confidence: 99%

Genetics of the phenotypic evolution in sheep: a molecular look at diversity-driving genes

et al. 2022

View full text Add to dashboard Cite

Background After domestication, the evolution of phenotypically-varied sheep breeds has generated rich biodiversity. This wide phenotypic variation arises as a result of hidden genomic changes that range from a single nucleotide to several thousands of nucleotides. Thus, it is of interest and significance to reveal and understand the genomic changes underlying the phenotypic variation of sheep breeds in order to drive selection towards economically important traits. Review Various traits contribute to the emergence of variation in sheep phenotypic characteristics, including coat color, horns, tail, wool, ears, udder, vertebrae, among others. The genes that determine most of these phenotypic traits have been investigated, which has generated knowledge regarding the genetic determinism of several agriculturally-relevant traits in sheep. In this review, we discuss the genomic knowledge that has emerged in the past few decades regarding the phenotypic traits in sheep, and our ultimate aim is to encourage its practical application in sheep breeding. In addition, in order to expand the current understanding of the sheep genome, we shed light on research gaps that require further investigation. Conclusions Although significant research efforts have been conducted in the past few decades, several aspects of the sheep genome remain unexplored. For the full utilization of the current knowledge of the sheep genome, a wide practical application is still required in order to boost sheep productive performance and contribute to the generation of improved sheep breeds. The accumulated knowledge on the sheep genome will help advance and strengthen sheep breeding programs to face future challenges in the sector, such as climate change, global human population growth, and the increasing demand for products of animal origin.

show abstract

Full-Length Transcriptome Characterization and Functional Analysis of Pathogenesis-Related Proteins in Lilium Oriental Hybrid ‘Sorbonne’ Infected with Botrytis elliptica

Chai

Sun

et al. 2022

IJMS

View full text Add to dashboard Cite

Gray mold (Botrytis elliptica) causes a deleterious fungal disease that decreases the ornamental value and yield of lilies. Lilium oriental hybrid ‘Sorbonne’ is a variety that is resistant to gray mold. Understanding the mechanism of resistance against B. elliptica infection in ‘Sorbonne’ can provide a basis for the genetic improvement in lily plants. In this study, a PacBio Sequel II system was used to sequence the full-length transcriptome of Lilium ‘Sorbonne’ after inoculation with B. elliptica. A total of 46.64 Gb subreads and 19,102 isoforms with an average length of 1598 bp were obtained. A prediction analysis revealed 263 lncRNAs, and 805 transcription factors, 4478 simple sequence repeats, and 17,752 coding sequences were identified. Pathogenesis-related proteins (PR), which may play important roles in resistance against B. elliptica infection, were identified based on the full-length transcriptome data and previously obtained second-generation transcriptome data. Nine non-redundant potential LhSorPR proteins were identified and assigned to two groups that were composed of two LhSorPR4 and seven LhSorPR10 proteins based on their genetic relatedness. The real-time quantitative reverse transcription PCR (qRT-PCR) results showed that the patterns of expression of nine differentially expressed PR genes under B. elliptica stress were basically consistent with the results of transcriptome sequencing. The pattern of expression of LhSorPR4s and LhSorPR10s genes in different tissues was analyzed, and the expression of each gene varied. Furthermore, we verified the function of LhSorPR4-2 gene in Lilium. The expression of LhSorPR4-2 was induced by phytohormones such as methyl jasmonate, salicylic acid, and ethephon. Moreover, the promoter region of LhSorPR4-2 was characterized by several functional domains associated with phytohormones and stress response. The overexpression of LhSorPR4-2 gene in ‘Sorbonne’ increased the resistance of the lily plant to B. elliptica and correlated with high chitinase activity. This study provides a full-length transcript database and functionally analyzed the resistance of PR gene to B. elliptica in Lilium, thereby introducing the candidate gene LhSorPR4-2 to breed resistance in Lilium.

show abstract

STAT3 Partly Inhibits Cell Proliferation via Direct Negative Regulation of FST Gene Expression

Cited by 3 publications

References 65 publications

Identification of key genes and signaling pathways related to Hetian sheep wool density by RNA-seq technology

Identification of key genes and signaling pathways related to Hetian sheep wool density by RNA-seq technology

Genetics of the phenotypic evolution in sheep: a molecular look at diversity-driving genes

Full-Length Transcriptome Characterization and Functional Analysis of Pathogenesis-Related Proteins in Lilium Oriental Hybrid ‘Sorbonne’ Infected with Botrytis elliptica

Contact Info

Product

Resources

About