STAT3 targeting by polyphenols: Novel therapeutic strategy for melanoma

Momtaz, Saeideh; Niaz, Kamal; Maqbool, Faheem; Abdollahi, Mohammad; Rastrelli, Luca; Nabavi, Seyed Mohammad

doi:10.1002/biof.1345

Cited by 37 publications

(27 citation statements)

References 275 publications

(342 reference statements)

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“…STAT3 is a member of STAT family of transcription factors, which plays a key role in cell apoptosis, proliferation, metastasis, angiogenesis, and immune escape. 18-20 Downregulation of the protein is consistent with the observation of cell apoptosis and proliferation inhibition. Because apoptosis was observed in the absence of caspase 3, it remains to be explored whether GSSG liposomes caused a caspase 3–independent apoptosis.…”

Section: Resultssupporting

confidence: 83%

In Vitro and In Vivo Tumor Growth Inhibition by Glutathione Disulfide Liposomes

Sadhu

Wang

Dachineni

et al. 2017

Cancer�Growth�Metastasis

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Glutathione disulfide (GSSG) is an endogenous peptide and the oxidized form of glutathione. The impacts of GSSG on cell function/dysfunction remain largely unexplored due to a lack of method to specifically increase intracellular GSSG. We recently developed GSSG liposomes that can specifically increase intracellular GSSG. The increase affected 3 of the 4 essential steps (cell detachment, migration, invasion, and adhesion) of cancer metastasis in vitro and, accordingly, produced a significant inhibition of cancer metastasis in vivo. In this investigation, the effect of GSSG liposomes on cancer growth was investigated with B16-F10 and NCI-H226 cells in vitro and with B16-F10 cells in C57BL/6 mice in vivo. Experiments were conducted to elucidate the effect on cell death through promotion of apoptosis and the effect on the cell cycle. The in vivo results with C57BL/6 mice implanted subcutaneously with B16-F10 cells showed that GSSG liposomes retarded tumor proliferation more effectively than that of dacarbazine, a chemotherapeutic drug for the treatment of melanoma. The GSSG liposomes by intravenous injection (GLS IV) and GSSG liposomes by intratumoral injection (GLS IT) showed a tumor proliferation retardation of 85% ± 5.7% and 90% ± 3.9%, respectively, compared with the phosphate-buffered saline (PBS) control group. The median survival rates for mice treated with PBS, blank liposomes, aqueous GSSG, dacarbazine, GLS IV, and GLS IT were 7, 7, 7.5, 7.75, 11.5, and 16.5 days, respectively. The effective antimetastatic and antigrowth activities warrant further investigation of the GSSG liposomes as a potentially effective therapeutic treatment for cancer.

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Section: Resultssupporting

confidence: 83%

In Vitro and In Vivo Tumor Growth Inhibition by Glutathione Disulfide Liposomes

Sadhu

Wang

Dachineni

et al. 2017

Cancer�Growth�Metastasis

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“…More-recently, Momtaz et al [149] has shown the influence of Ole on melanoma. Melanoma is certainly one of the most aggressive skin cancers, due to its progression to drug resistance and its organ dissemination.…”

Section: Multiple Checkprotein Of Transcription Of Oleuropeinmentioning

confidence: 97%

Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases

et al. 2019

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Growing scientific literature data suggest that the intake of natural bioactive compounds plays a critical role in preventing or reducing the occurrence of human chronic non-communicable diseases (NCDs). Oleuropein, the main phenolic component of Olea europaea L., has attracted scientific attention for its several health beneficial properties such as antioxidant, anti-inflammatory, cardio- and neuro-protective, and anti-cancer. This article is a narrative review focused on the current literature concerning the effect of oleuropein in NCDs, such as neuro- and cardiovascular diseases, diabetes mellitus, chronic kidney diseases, and cancer, by its putative antioxidant and anti-inflammatory activity, but also for its other peculiar actions such as an autophagy inducer and amyloid fibril growth inhibitor and, finally, for its anti-cancer effect. Despite the increasing number of published studies, looking at the beneficial effects of oleuropein, there is limited clinical evidence focused on the benefits of this polyphenol as a nutraceutical product in humans, and many problems are still to be resolved about its bioavailability, bioaccessibility, and dosage. Thus, future clinical randomized trials are needed to establish the relation between the beneficial effects and the mechanisms of action occurring in the human body in response to the intake of oleuropein.

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“…STAT3 can affect the metastasis of cells in many ways. 20,21 Among them STAT3/mmp2 pathway is a common pathway. We wondered if miR-337 could regulate the metastasis of melanoma cells by suppressing STAT3/mmp2 pathway.…”

Section: Mir-337 Inhibits the Metastasis Of Melanoma Cellsmentioning

confidence: 99%

miR-337 can be a key negative regulator in melanoma

Xiao

Yao

Zheng

et al. 2017

Cancer Biology & Therapy

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Incidence of melanoma is increasing annually worldwide. There remains a lack of suitable treatment methods which can significantly improve the 5-year survival rates of patients. It is established that micro RNAs (miRNAs) have important roles in the diagnosis and treatment of cancer. MiR-337 had been reported to regulate the development of variety of cancers, as a cancer suppressive factor. In our research we found that miR-337 had a lower expression in melanoma than adjacent tissues. The patients who had a lower miR-337 also got a worse survival. MiR-337 could target STAT3 to regulate the occurrence and development of melanoma. In summary, our findings suggest that the miR-337/STAT3 axis may serve as a potential target for the treatment of melanoma.

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STAT3 targeting by polyphenols: Novel therapeutic strategy for melanoma

Cited by 37 publications

References 275 publications

In Vitro and In Vivo Tumor Growth Inhibition by Glutathione Disulfide Liposomes

In Vitro and In Vivo Tumor Growth Inhibition by Glutathione Disulfide Liposomes

Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases

miR-337 can be a key negative regulator in melanoma

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