STAT4 gene influences genetic predisposition to ulcerative colitis but not Crohn's disease in the Spanish population: A replication study

The CREM gene is involved in genetic predisposition to inflammatory bowel disease in the Tunisian population

“…In contrast, a Spanish study including 674 IBD patients reported a significant association of the STAT4 variant rs7574865 with CD susceptibility [39]. Another recent study from Spain reported no association of the STAT4 SNP rs7574865 with CD and UC [40], whereas an extended meta-analysis indicated a disease association of this SNP with UC and not CD in the Spanish population [41]. Considering the limited data of STAT4 gene variants in IBD patients and the conflicting results from the Spanish studies, the impact of STAT4 on IBD susceptibility seems limited, but a trend does exist supporting a possible role of STAT4 in UC susceptibility.…”

Analysis of the influence of two CD24 genetic variants in Crohn's disease and ulcerative colitis

“…Demographic and clinical characteristics of the subjects have been previously described [21]. Written informed consent was obtained from all participants.…”

Association of STAT4 rs7574865 polymorphism with susceptibility to inflammatory bowel disease: A systematic review and meta-analysis

“…These differences may be caused by pleiotropic effects of specific genes on a common polygenic and multifactor background. The distinct influence of the STAT4 gene on IBD risk observed in our study provides an example of the differences in genetic background between these two intestinal inflammatory disorders [20].…”

“…Recently, STAT4 haplotype characterized by the rs7574865 polymorphism was reported to be significantly associated with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and other autoimmune diseases such as Sjögren's syndrome, type 1 diabetes, and systemic sclerosis [16][17][18]. Interestingly, a recent casecontrol study conducted in a Spanish population showed that the T allele of the STAT4 rs7574865 was associated with IBD [19], and this association has been replicated by Diaz-Gallo et al [20] and Glas et al [21], they reported that rs7574865 polymorphism was associated with colonic CD and early disease onset in Caucasians. However, there are also some other studies did not confirm these findings.…”

“…Based on our search criteria, a total of seven eligible studies concerning the STAT4 rs7574865 polymorphism and IBD risk were included in the final meta-analysis [19][20][21][22][23][24][25], comprising 2196 CD cases, 1588 UC cases and 4126 controls. The flow chart of the study selection process is shown in Fig.…”