State-dependent encoding of sound and behavioral meaning in a tertiary region of the ferret auditory cortex

Elgueda, Diego; Duque, Daniel; Radtke‐Schuller, Susanne; Yin, Pingbo; David, Stephen V.; Shamma, Shihab A.; Fritz, Jonathan B.

doi:10.1038/s41593-018-0317-8

Cited by 69 publications

(58 citation statements)

References 58 publications

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“…These findings cannot be explained by damage to A1 or a lack of GCaMP6f expression since we clearly observed A1 activation in all mice during sensory mapping (Figure S1) as well as upon task replay during anesthesia and in response to auditory cues in the tactile task (Figure S3). Rather, they indicate a particularly strong role of higher auditory areas during task engagement, in line with recent reports from various mammalian species (Atiani et al, 2014;Dong et al, 2013;Elgueda et al, 2019;Niwa et al, 2013;Tsunada et al, 2015). The strong connections of AD with PPC and secondary motor cortex Zhong et al, 2019) might also indicate a more prominent role compared to A1 in auditory decisionmaking tasks, a notion that remains to be further investigated and causally tested in the future.…”

Section: Particularities Of Auditory Evoked Cortical Signal Flowsupporting

confidence: 86%

Sensory and Behavioral Components of Neocortical Signal Flow in Discrimination Tasks with Short-term Memory

Gallero‐Salas

Laurenczy

Voigt

et al. 2020

Preprint

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In neocortex, each sensory modality engages distinct primary and secondary areas that route information further to association areas. Where signal flow may converge for maintaining information in short-term memory and how behavior may influence signal routing remain open questions. Using wide-field calcium imaging, we compared cortexwide neuronal activity in layer 2/3 for mice trained in auditory and whisker-based tactile discrimination tasks with delayed response. In both tasks, mice were either active or passive during stimulus presentation, engaging in body movements or sitting quietly. A and RL, respectively). In the subsequent delay period, in contrast, behavioral strategy rather than sensory modality determined where short-term memory was located: frontomedially in active trials and posterolaterally in passive trials. Our results suggest behavior-dependent routing of sensory-driven cortical information flow from modality-specific PPC subdivisions to higher association areas. Irrespective of behavioral strategy, auditory and tactile stimulation activated spatially segregated subdivisions of posterior parietal cortex (areas

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Section: Particularities Of Auditory Evoked Cortical Signal Flowsupporting

confidence: 86%

Sensory and Behavioral Components of Neocortical Signal Flow in Discrimination Tasks with Short-term Memory

Gallero‐Salas

Laurenczy

Voigt

et al. 2020

Preprint

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“…The ferret is a promising animal model for exploring the neurobiology of the frontal cortex (FC). It has gained increasing interest as a result of recent studies on the role of the dorsal FC in top-down cognitive control of sensory processing (Fritz et al 2010;Francis et al 2018;Bimbard et al 2018;Elgueda et al 2019), in goal-directed behavior (Zhou et al 2016), in the interactions in the frontoparietal attention network (Sellers et al 2016), and as a model system to study the effects of anesthesia (Sellers et al 2013(Sellers et al , 2015Wollstadt et al 2017). Moreover, in vitro studies of FC functional microcircuitry have also been carried out in the ferret (Krimer and Goldman-Rakic 2001;McCormick et al 2003;Shu et al 2006Shu et al , 2007Wang et al 2006;Winograd et al 2008) and have been recently developed as an in vitro model of schizophrenia (Rebollo et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Dorsal prefrontal and premotor cortex of the ferret as defined by distinctive patterns of thalamo-cortical projections

et al. 2020

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Recent studies of the neurobiology of the dorsal frontal cortex (FC) of the ferret have illuminated its key role in the attention network, top-down cognitive control of sensory processing, and goal directed behavior. To elucidate the neuroanatomical regions of the dorsal FC, and delineate the boundary between premotor cortex (PMC) and dorsal prefrontal cortex (dPFC), we placed retrograde tracers in adult ferret dorsal FC anterior to primary motor cortex and analyzed thalamo-cortical connectivity. Cyto-and myeloarchitectural differences across dorsal FC and the distinctive projection patterns from thalamic nuclei, especially from the subnuclei of the medial dorsal (MD) nucleus and the ventral thalamic nuclear group, make it possible to clearly differentiate three separate dorsal FC fields anterior to primary motor cortex: polar dPFC (dPFCpol), dPFC, and PMC. Based on the thalamic connectivity, there is a striking similarity of the ferret's dorsal FC fields with other species. This possible homology opens up new questions for future comparative neuroanatomical and functional studies.

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“…See also Figure S6. Fritz et al, 2003;Fritz et al, 2005Fritz et al, , 2007Kuchibhotla et al, 2017;Otazu et al, 2009) or higher cortical areas (Atiani et al, 2014;Elgueda et al, 2019). With a few exceptions (Otazu et al, 2009;Slee and David, 2015), response modulations in IC, MGB, and AAF have instead been largely overlooked.…”

Section: Discussionmentioning

confidence: 99%

Task-induced modulations of neuronal activity along the auditory pathway

Franceschi¹,

Barkat²

2020

Preprint

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Sensory processing varies depending on behavioral context. Here, we asked how task-engagement modulates neurons in the auditory system. We trained mice in a simple tone-detection task, and compared their neuronal activity during passive hearing and active listening. Electrophysiological extracellular recordings in the inferior colliculus, medial geniculate body, primary auditory cortex and anterior auditory field revealed widespread modulations across all regions and cortical layers, and in both putative regular and fast-spiking cortical neurons. Clustering analysis unveiled ten distinct modulation patterns that could either enhance or suppress neuronal activity. Task-engagement changed the tone-onset response in most neurons. Such modulations first emerged in subcortical areas, ruling out cortical feedback from primary auditory areas as the only mechanism underlying subcortical modulations. Half the neurons additionally displayed late modulations associated with licking, arousal or reward. Our results reveal the presence of functionally distinct subclasses of neurons, differentially sensitive to specific task-related variables but anatomically distributed along the auditory pathway.

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State-dependent encoding of sound and behavioral meaning in a tertiary region of the ferret auditory cortex

Cited by 69 publications

References 58 publications

Sensory and Behavioral Components of Neocortical Signal Flow in Discrimination Tasks with Short-term Memory

Sensory and Behavioral Components of Neocortical Signal Flow in Discrimination Tasks with Short-term Memory

Dorsal prefrontal and premotor cortex of the ferret as defined by distinctive patterns of thalamo-cortical projections

Task-induced modulations of neuronal activity along the auditory pathway

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