State of the art in vivo imaging techniques for laboratory animals

Lauber, David Tibor; Fülöp, András; Kovács, Tibor; Szigeti, Krisztián; Máthé, Domokos; Szíjártó, Attila

doi:10.1177/0023677217695852

Cited by 66 publications

(67 citation statements)

References 114 publications

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“…İteratif rekonstrüksiyon, hem klinik hem de preklinik SPECT cihazlarında en çok tercih edilen yöntemdir. Yüksek iterasyonlarda daha iyi görüntü kontrastı ve rezolüsyonu elde edilebilmektedir (1,2).…”

Section: Mikrospectunclassified

“…T1 ve T2 fazları vardır. MikroMRG sistemlerde ince anatomik detayları görmek amacıyla daha iyi bir çözünürlük ve yüksek sinyal/ gürültü (SNR) oranı sağlamak için daha güçlü homojen bir manyetik alan (en az 4,7 tesla, ideali 7 tesla ve üzeri), özelleştirilmiş koiller ve RF zincirleri dizayn edilmiştir (2). Klinik MRG'de voksel boyutu 1,5×1,5×10 mm 3 ve hacim 23 mL iken, micro MRG'de 100×100×500 mm 3 ile voksel boyutu 3000 kez daha küçüktür ve hacim 5 nL'dir.…”

Section: Mikromrgunclassified

“…Klinik MRG'de voksel boyutu 1,5×1,5×10 mm 3 ve hacim 23 mL iken, micro MRG'de 100×100×500 mm 3 ile voksel boyutu 3000 kez daha küçüktür ve hacim 5 nL'dir. MikroMRG'de 21 teslaya kadar çıkabilen güçlü manyetik alanda süper iletkenlik için gereken soğutma sıvı helyum yerine kriyojen manyetik sistemler ile sağlanmaktadır (2). Manyetik alanın gücü arttıkça ve koil (bobin) boyutu azaldıkça SNR artmaktadır.…”

Section: Mikromrgunclassified

“…Anahtar Kelimeler: Klinik öncesi, görüntüleme yöntemleri, in vivo fazla hedefi aynı anda görüntüleme, hayvan türü ve maliyet gibi unsurlar etkilidir (1). Her bir yöntemin kendine özgü avantaj ve dezavantajları mevcut olmakla birlikte iyonizan radyasyona maruziyet, çözünürlük, görüntüleme derinliği, kontrast ajanların kullanılabilirliği, moleküler işaretleme imkanı gibi parametreler tercih edilmelerindeki en önemli etkenlerdir (Tablo 1) (2).…”

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“…Klinik çalışmalar hastalığın prognozunu tayin etmede lezyon boyutunun yanında morfolojik ve fonksiyonel bilgilerin de gerekli olduğunu göstermiştir (1,2,3 Elementlerin çok düşük konsantrasyonlarını (pikomolar düzey) tespit edebilmeleri nedeniyle, moleküler görüntüleme için en uygun yöntemlerdir. Bu sistemlerle görüntülemede radyoaktif işaretleyiciler kullanılmaktadır.…”

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Imaging Modalities Used in Preclinical Studies

Karaçavuş¹

2019

nts

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Öz HangiModalite?Deney hayvanlarının noninvaziv görüntülenmesinde hedeflenen amaçlar doğrultusunda farklı modaliteler kullanılmaktadır. En uygun yöntemin seçilmesinde ilgilenilen parametre yani boyut, fonksiyon, istenilen uzaysal ve temporal rezolüsyon ve sensitivite, dinamik veriye ihtiyaç, tüm vücut/bölgesel veri gerekliliği, çekim süresi, penetrasyon derinliği, kantitatif veriye ihtiyaç, çoklu/tekrarlayan çalışmaya ihtiyaç, birden Imaging modalities have long been indispensable tool in clinical and preclinical practice or drug development. Increasingly, in vivo imaging of small laboratory animals has gained importance as a critical component of preclinical biomedical research as well. The most used modalities for small-animal in vivo imaging applications are based on nuclear medicine techniques (especially, positron emission tomography [PET] and single photon emission computed tomography [SPECT]), computed tomography (CT), and magnetic resonance imaging (MRI). Each modality has intrinsic strengths and limitations, and the choice of the imaging modality depends on the parameter of interest.Recently, aiming to overcome the limitations of each imaging modality, multimodality devices designed to provide complementary information upon the pathophysiological process under study have emerged popularity. The combination of high-resolution modalities, like microCT or microMRI, with highly sensitive techniques providing functional information, such as microPET or microSPECT, will continue to broaden the horizons of research in such areas as infection, oncology, cardiology, and neurology, contributing not only to the understanding of the underlying mechanisms of disease but also providing efficient and unique tools for evaluating new chemical entities and development of candidate drugs. Ya zış maAd re si/Ad dressforCor res pon den ce

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Section: Mikrospectunclassified

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Imaging Modalities Used in Preclinical Studies

Karaçavuş¹

2019

nts

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Linguistic Analysis Identifies Emergent Biomaterial Fabrication Trends for Orthopaedic Applications

Locke

Zlotnick

Stoeckl

et al. 2023

Adv Healthcare Materials

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The expanse of publications in tissue engineering (TE) and orthopedic TE (OTE) over the past 20 years presents an opportunity to probe emergent trends in the field to better guide future technologies that can make an impact on musculoskeletal therapies. Leveraging this trove of knowledge, a hierarchical systematic search method and trend analysis using connected network mapping of key terms is developed. Within discrete time intervals, an accelerated publication rate for anatomic orthopedic tissue engineering (AOTE) of osteochondral defects, tendons, menisci, and entheses is identified. Within these growing fields, the top-listed key terms are extracted and stratified into evident categories, such as biomaterials, delivery method, or 3D printing and biofabrication. It is then identified which categories decreased, remained constant, increased, or emerged over time, identifying the specific emergent categories currently driving innovation in orthopedic repair technologies. Together, these data demonstrate a significant convergence of material types and descriptors used across tissue types. From this convergence, design criteria to support future research of anatomic constructs that mimic both the form and function of native tissues are formulated. In summary, this review identifies large-scale trends and predicts new directions in orthopedics that will define future materials and technologies.

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Organic fluorescent nanoprobes with NIR‐IIb characteristics for deep learning

Wanderi

Cui

2022

Exploration

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Illumination of biological events with near-infrared II sub-channel (NIR-IIb, 1500-1700 nm) enhances the transparency of biological tissues, which is very attractive for deep imaging. Due to the long-wavelength, which reduces optical damage, suppresses autofluorescence, and obviates light scattering, NIR-IIb nanoprobes afford deep tissue penetration with unprecedented spatiotemporal resolution. Hence, NIR-IIb imaging facilitates deep learning and decipherment of biological proceedings in living organisms with astounding high clarity. In comparison to its predecessors in the visible-nearinfrared spectrum, imaging in the NIR-IIb has shown great potential for tissue imaging and extrapolating imaging applications for clinical studies. However, the use of organic fluorescent nanoprobes (OFNPs) in the NIR-IIb region is still rare since it is in its early stages. Thus, herein we aim to survey the recent development of different organic fluorescent nanomaterials with NIR-IIb characteristics, their unique photophysical properties, and their utilization in deep imaging in animal models. Further, practical researches on organic fluorescent nanoprobes with NIR-IIb emission and their transition to clinical applications are highlighted.

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State of the art in vivo imaging techniques for laboratory animals

Cited by 66 publications

References 114 publications

Imaging Modalities Used in Preclinical Studies

Imaging Modalities Used in Preclinical Studies

Linguistic Analysis Identifies Emergent Biomaterial Fabrication Trends for Orthopaedic Applications

Organic fluorescent nanoprobes with NIR‐IIb characteristics for deep learning

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