The article examines the relationship between regionalization and globalization at the present stage, identifies trends in the development of regionalization, as well as gaps in the international legal regulation of combating transnational crime in the SCO and CIS regions. The relevance of the fight against transnational crime in the modern conditions of the implementation of the state foreign policy of the Russian Federation and the development of regionalization processes is noted. Statistics on transnational crimes that affect the regions of the SCO, the CIS and the immediate territory of the Russian Federation are presented, and the wave-like dynamics in the number of these crimes is revealed. The relevance of the fight against transnational crime is, among other things, associated with the growing number of crimes of terrorist and extremist nature. The authors point out the need to conduct statistical studies of the number of transnational crimes and their individual types in order to establish the proportion of crimes committed exclusively on the territory of the Russian Federation and affecting the interests of foreign states (properly transnational). The system of measures aimed at combating transnational crime includes the following: legislative, procedural (international cooperation); professional (improving the qualification of law enforcement agencies’ employees); technical (development and implementation of innovative technologies) and financial measures. The work identifies promising directions for improving this system of measures. Statistical data from the Prosecutor General's Office of the Russian Federation and the Ministry of Internal Affairs of the Russian Federation, the Investigative Committee of the Russian Federation are provided. The analysis of the state and level of transnational crime and the problems associated with countering it allowed the authors to identify a number of promising areas. Specifically, it is proposed that a number of pressing problems should be solved in order to stabilize international cooperation at the regional level.