With the continuous acceleration of globalization and rapid technological development, cross-border interconnectivity has become an important force shaping the current international relations landscape. This work delves into the influence of cross-border interconnectivity on the construction of new international relations and analyzes in detail its practices and developments in China's relations with neighboring countries. The findings reveal that cross-border interconnectivity not only promotes the strengthening of economic, political, and cultural ties among countries but also drives the diversified and inclusive development of new international relations. However, it is also necessary to confront the numerous challenges posed by cross-border interconnectivity, such as constraints from major powers and cross-border security risks. In order to address these challenges, this work proposes a series of recommendations. First, strengthen political dialogue between countries and enhance trust in China among neighboring countries through open and transparent cooperation mechanisms. Moreover, deepen regional security cooperation, jointly address cross-border security risks, and maintain regional peace and stability. Additionally, make efforts to enhance the governance capacity of neighboring countries to better adapt to the cooperation needs of cross-border interconnectivity. These recommendations not only provide practical guidance for addressing the complexity brought by cross-border interconnectivity but also substantially contribute to promoting global cooperative relations. This work provides an important contribution to the academic community by comprehensively analyzing the multifaceted impact of cross-border interconnectivity on international relations. Simultaneously, this work offers valuable insights for decision-makers and scholars by delving into the practical experiences and challenges faced by China in its interactions with neighboring countries.