Static, but not optokinetic visual stimuli induce Fos expression in the retina and brain of retinal degeneration mice

Lima, Alexandre Gibau de; Britto, Luiz Roberto Giorgetti de; Hossokawa, Neide M.; Hamassaki‐Britto, Dânia Emi

doi:10.1016/s0304-3940(03)00217-9

Cited by 3 publications

(6 citation statements)

References 20 publications

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“…Koistinaho and Sagar (1995) obtained also c-Fos positive nuclei in the GCL and the INL of dark-adapted rabbits exposed to flashing light (3 Hz, 60 ms, 300 lux) for 2 h. Bussolino et al (1998) found that light differences for phospholipid labeling correlate with the expression of c-Fos: that is, in the GCL the c-Fos expression and phospholipid synthesis is higher in light with respect to dark. Lima et al (2003) obtained also c-Fos positive nuclei in the GCL and the INL of dark-adapted retinal degeneration mice exposed to 1 h of diffuse light (900 lux) or optokinetic stimuli (180 lux).…”

Section: Ganglion Cell Layer and Inner Nuclear Layermentioning

confidence: 87%

“…A few published reports (Montero and Jian, 1995;CorreaLacarcel et al, 2000;Lima et al, 2003) exist which analyze the immunoreactivity for the c-Fos protein at the level of subcortical structures. Montero and Jian (1995) found Fos immunoreactive populations of neurons in retinotopically corresponding regions of the stratum griseum superficiale and in the stratum opticum after exposing dark-adapted rats to moving and stationary visual stimuli.…”

Section: Superior Colliculusmentioning

confidence: 99%

“…On the contrary, continuous and high frequency light elicited low c-Fos expression levels in these centers. Lima et al (2003) only stated to have found Fos staining after diffuse light stimulation in several retinorecipients structures of the mouse brain, such as the superior colliculus.…”

Section: Superior Colliculusmentioning

confidence: 99%

“…This property is of great importance, because it offers a valuable tool for morphofunctional identification of activated neurons (Kaczmarek, 2002). c-Fos induction by light has been mostly studied in rats, mice, rabbits and hamsters, in the suprachiasmatic nucleus in relation to changes of general illumination and circadian rhythms (Rea, 1989;Aronin et al, 1990;Rusak et al, 1990;Chambille et al, 1993;Earnest and Olschowka, 1993;Vuillez et al, 1994); in response to global flashes of light in the retina and central visual pathways Craner et al, 1992;Koistinaho et al, 1993) and after pattern visual stimulation (Yoshida et al, 1993;Montero and Jian, 1995;Harada et al, 1996;Bussolino et al, 1998;CorreaLacarcel et al, 2000;Lima et al, 2003). Sagar et al (1988), in order to determine whether the c-Fos protein and Fos-related proteins can be induced in response to polysynaptic activation, stimulated electrically the rat hindlimb motor/sensory cortex and examined the Fos expression immunohistochemically.…”

mentioning

confidence: 99%

“…A surprisingly high positive immunoresponsiveness was obtained in all cases with coherent light stimulation in the red spectrum (634 nm). Lima et al (2003) studied the c-fos gene expression to characterize the residual vision of retinal degeneration mice after applying static and dynamic photic stimuli. They found diffuse light induced Fos-positive nuclei in the INL and GCL of the mice retina.…”

mentioning

confidence: 99%

See 4 more Smart Citations

c-Fos expression in the visual system of the tree shrew (Tupaia belangeri)

Poveda¹,

Kretz²

2009

Journal of Chemical Neuroanatomy

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Section: Ganglion Cell Layer and Inner Nuclear Layermentioning

confidence: 87%

Section: Superior Colliculusmentioning

confidence: 99%

Section: Superior Colliculusmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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c-Fos expression in the visual system of the tree shrew (Tupaia belangeri)

Poveda¹,

Kretz²

2009

Journal of Chemical Neuroanatomy

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Acute effects of light on the brain and behavior of diurnal Arvicanthis niloticus and nocturnal Mus musculus

Shuboni

Cramm

Yan

et al. 2015

Physiology & Behavior

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Photic cues influence daily patterns of activity via two complementary mechanisms: (1) entraining the internal circadian clock and (2) directly increasing or decreasing activity, a phenomenon referred to as “masking”. The direction of this masking response is dependent on the temporal niche an organism occupies, as nocturnal animals often decrease activity when exposed to light, while the opposite response is more likely to be seen in diurnal animals. Little is known about the neural mechanisms underlying these differences. Here, we examined the masking effects of light on behavior and the activation of several brain regions by that light, in diurnal Arvicanthis niloticus (Nile grass rats) and nocturnal Mus musculus (mice). Each species displayed the expected behavioral response to a 1 h pulse of light presented 2 h after lights-off, with the diurnal grass rats and nocturnal mice increasing and decreasing their activity, respectively. In grass rats light induced an increase in cFOS in all retinorecipient areas examined, which included the suprachiasmatic nucleus (SCN), the ventral subparaventricular zone (vSPZ), intergeniculate leaflet (IGL), lateral habenula (LH), olivary pretectal nucleus (OPT) and the dorsal lateral geniculate (DLG). In mice, light led to an increase in cFOS in one of these regions (SCN), no change in others (vSPZ, IGL and LH) and a decrease in two (OPT and DLG). In addition, light increased cFOS expression in three arousal-related brain regions (the lateral hypothalamus, dorsal raphe, and locus coeruleus) and in one sleep-promoting region (the ventrolateral preoptic area) in grass rats. In mice, light had no effect on cFOS in these four regions. Taken together, these results highlight several brain regions whose responses to light suggest that they may play a role in masking, and that the possibility that they contribute to species-specific patterns of behavioral responses to light should be explored in future.

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Lomerizine, a Ca²⁺ Channel Blocker, Protects against Neuronal Degeneration within the Visual Center of the Brain after Retinal Damage in Mice

Ito

Nakamura

Tsuruma

et al. 2010

CNS Neuroscience & Therapeutics

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The purpose of this study was to determine whether lomerizine, a Ca(2+) channel blocker, protects against neuronal degeneration within the dorsal lateral geniculate nucleus (dLGN) and superior colliculus (SC) after the induction of retinal damage by intravitreal injection of N-methyl-D-aspartate (NMDA) in mice. NMDA (20 mM/2 microL) was injected into the vitreous body of the left eye in mice (DAY 0). Lomerizine at 30 mg/kg, p.o. was administered daily from immediately after the injection of NMDA (DAY 0) to 90 days after (DAY 90). To investigate the neuroprotective effects of lomerizine, the retina, dLGN, and SC were examined using histochemistry and immunohistochemistry. Lomerizine reduced the retinal damage induced by NMDA and partially prevented the transsynaptic neuronal degeneration within dLGN and SC on the contralateral side. Moreover, lomerizine reduced the intravitreal NMDA induced decrease in the light-induced expression of c-Fos in the contralateral dLGN (used in this study to evaluate residual vision). These results indicate that lomerizine affords some protection against transsynaptic neuronal degeneration within the visual center of the mouse brain.

show abstract

Static, but not optokinetic visual stimuli induce Fos expression in the retina and brain of retinal degeneration mice

Cited by 3 publications

References 20 publications

c-Fos expression in the visual system of the tree shrew (Tupaia belangeri)

c-Fos expression in the visual system of the tree shrew (Tupaia belangeri)

Acute effects of light on the brain and behavior of diurnal Arvicanthis niloticus and nocturnal Mus musculus

Lomerizine, a Ca²⁺ Channel Blocker, Protects against Neuronal Degeneration within the Visual Center of the Brain after Retinal Damage in Mice

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Static, but not optokinetic visual stimuli induce Fos expression in the retina and brain of retinal degeneration mice

Cited by 3 publications

References 20 publications

c-Fos expression in the visual system of the tree shrew (Tupaia belangeri)

c-Fos expression in the visual system of the tree shrew (Tupaia belangeri)

Acute effects of light on the brain and behavior of diurnal Arvicanthis niloticus and nocturnal Mus musculus

Lomerizine, a Ca2+ Channel Blocker, Protects against Neuronal Degeneration within the Visual Center of the Brain after Retinal Damage in Mice

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Product

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About

Lomerizine, a Ca²⁺ Channel Blocker, Protects against Neuronal Degeneration within the Visual Center of the Brain after Retinal Damage in Mice