Static magnetic field action on some markers of inflammation in animal model system—in vivo

Abstract

Experimentally induced acute inflammation in rats is a good model system which includes the complexity and dynamics of the processes; moreover there are many defined markers for following and estimating changes in an observed system. In this paper, we discuss an in vivo model of acute inflammation induced by carrageenan. Carrageenan-induced paw edema is a model of non-infectious acute inflammatory reaction to assess the contribution of mediators involved in vascular changes associated with acute inflammation and potential treatments. A complex approach into the investigation of possible effects of static magnetic fields (SMF) action on experimentally induced acute inflammation in rats (by measurements of the levels of specific stress markers) is very important in understanding the possible inflammatory mitigation effects, pain relief, and oxidative stress state of an organism. This approach could help for better understanding of the possible mechanisms of interaction of dynamic processes such as inflammation healing and pain relief with external SMF (25 mT at 10, 20 and 30 min exposure time). Results indicate that SMF with B = 25 mT for 30 min diminished the inflammatory process and decreased the levels of inflammatory markers (fibrinogen) and stress markers (ACTH, Cor) into the blood plasma in rats as when compared with sham exposed animals. The exact mechanism by which SMF contributes to the acceleration of inflammatory healing and decrease of inflammation markers in blood plasma in rats still remains unclear. We assume that two possible mechanisms exist. One is the direct interaction of SMF with free active oxygen forms (free radicals) affected by their membrane processes and related with the physiological functions. Another possible mechanism might be related to dynamic regulation of inflammation healing process.

Effect of static magnetic fields and phloretin on antioxidant defense system of human fibroblasts

“…However, this study was only performed at the protein level, not at the molecular level. Similarly, Traikov et al ( 2009 ) indicated that exposure to 25-mT SMF decreased the levels of inflammatory and stress markers in rat blood plasma. Many researchers have also observed the lethal effects of moderate and strong SMFs combined with chemotherapy drugs on cancer cells such as K562 (human leukemia cells), HTB 63 (melanoma), HTB 77 IP3 (ovarian carcinoma), and CCL 86 (lymphoma, Raji cells) cell lines (Raylman et al 1996 ; Sun et al 2012 ).…”

Effect of static magnetic field on bone and its molecular mechanism

“…15或30 min, 发现10和70 mT静磁场可引起水肿形成减 少20%~50% [43] . 将角叉菜胶诱发的足爪水肿大鼠在25 mT的静磁场中暴露30 min, 可明显减少炎症过程, 并 降低血浆中炎症标志物和应激标志物的水平 [44] . 此外, .…”

Pulslu manyetik alanın λ-carrageenan’ın indüklediği akut pençe ödeminde antioksidan sistem üzerine etkisi

“…Traikov et al indicated that static magnetic field (SMF) with 25 mT for 30 min diminished the inflammatory process and decreased the levels of inflammatory markers and stress markers into the λ-Carr-induced acute inflammation model 11 . In the other study, a magnetic field of 5 Hz x4 mT, 90 min was found to be optimal in lowering the paw edema volume and decreasing the activity of lysosomal enzymes.…”