Static magnetic field therapy: methodological challenges to conducting clinical trials

Colbert, Agatha P.; Souder, James; Markov, Marko S.

doi:10.1007/s10669-008-9203-3

Cited by 21 publications

(9 citation statements)

References 35 publications

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“…There are four SMF parameters relevant for the interaction with a biological system: target tissue(s), magnet characteristics, magnet support device, and dosing regimen [7]. SMFs are difficult to shield and can freely penetrate biological tissues [8].…”

Section: Introductionmentioning

confidence: 99%

Bioeffects of Static Magnetic Fields: Oxidative Stress, Genotoxic Effects, and Cancer Studies

Ghodbane

Lahbib

Sakly

et al. 2013

BioMed Research International

182

146

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The interaction of static magnetic fields (SMFs) with living organisms is a rapidly growing field of investigation. The magnetic fields (MFs) effect observed with radical pair recombination is one of the well-known mechanisms by which MFs interact with biological systems. Exposure to SMF can increase the activity, concentration, and life time of paramagnetic free radicals, which might cause oxidative stress, genetic mutation, and/or apoptosis. Current evidence suggests that cell proliferation can be influenced by a treatment with both SMFs and anticancer drugs. It has been recently found that SMFs can enhance the anticancer effect of chemotherapeutic drugs; this may provide a new strategy for cancer therapy. This review focuses on our own data and other data from the literature of SMFs bioeffects. Three main areas of investigation have been covered: free radical generation and oxidative stress, apoptosis and genotoxicity, and cancer. After an introduction on SMF classification and medical applications, the basic phenomena to understand the bioeffects are described. The scientific literature is summarized, integrated, and critically analyzed with the help of authoritative reviews by recognized experts; international safety guidelines are also cited.

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Section: Introductionmentioning

confidence: 99%

Bioeffects of Static Magnetic Fields: Oxidative Stress, Genotoxic Effects, and Cancer Studies

Ghodbane

Lahbib

Sakly

et al. 2013

BioMed Research International

182

146

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“…In addition, the SMFs can penetrate all biological tissue (Colbert et al . ). Therefore, the covering tooth structure and restoration have a limited negative effect on the SMF.…”

Section: Discussionmentioning

confidence: 97%

Use of 0.4‐Tesla static magnetic field to promote reparative dentine formation of dental pulp stem cells through activation of p38 MAPK signalling pathway

et al. 2018

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“…Owing to the frequent exposure of living beings to magnetic fields, the sensitivity of different biological systems to magnetic fields has been studied for many years [ 41 ]. It is necessary to understand the influence of magnetic fields from different sources on the human body.…”

Section: Discussionmentioning

confidence: 99%

Static Magnetic Fields Modulate the Response of Different Oxidative Stress Markers in a Restraint Stress Model Animal

Coballase-Urrutía¹,

Navarro

Ortiz³

et al. 2018

BioMed Research International

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Stress is a state of vulnerable homeostasis that alters the physiological and behavioral responses. Stress induces oxidative damage in several organs including the brain, liver, kidney, stomach, and heart. Preliminary findings suggested that the magnetic stimulation could accelerate the healing processes and has been an effective complementary therapy in different pathologies. However, the mechanism of action of static magnetic fields (SMFs) is not well understood. In this study, we demonstrated the effects of static magnetic fields (0.8 mT) in a restraint stressed animal model, focusing on changes in different markers of oxidative damage. A significant increase in the plasma levels of nitric oxide (NO), malondialdehyde (MDA), and advanced oxidation protein products (AOPP), and a decrease in superoxide dismutase (SOD), glutathione (GSH), and glycation end products (AGEs) were observed in restraint stress model. Exposure to SMFs over 5 days (30, 60, and 240 min/day) caused a decrease in the NO, MDA, AGEs, and AOPP levels; in contrast, the SOD and GSH levels increased. The response to SMFs was time-dependent. Thus, we proposed that exposure to weak-intensity SMFs could offer a complementary therapy by attenuating oxidative stress. Our results provided a new perspective in health studies, particularly in the context of oxidative stress.

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Static magnetic field therapy: methodological challenges to conducting clinical trials

Cited by 21 publications

References 35 publications

Bioeffects of Static Magnetic Fields: Oxidative Stress, Genotoxic Effects, and Cancer Studies

Bioeffects of Static Magnetic Fields: Oxidative Stress, Genotoxic Effects, and Cancer Studies

Use of 0.4‐Tesla static magnetic field to promote reparative dentine formation of dental pulp stem cells through activation of p38 MAPK signalling pathway

Static Magnetic Fields Modulate the Response of Different Oxidative Stress Markers in a Restraint Stress Model Animal

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