Statin-associated muscle symptoms EAS Consensus Panel paper focuses on this neglected patient group

The Association between Metabolic Syndrome and Multiple Myeloma

“…This subsequently activates effector caspases and triggers a cascade of events with resultant apoptosis [93][94][95]. They also impair the production of prenylated proteins leading to impaired cellular signalling and the induction of apoptosis with a potential therapeutic use in MM [96,97].…”

Statin myopathy

“…Statin myalgia is typically more pronounced on walking down stairs or slopes. Its incidence varies widely from 1% in randomized controlled trials up to 25% in observational studies [5,14]. This discrepancy might be explained by differences in definitions used in reporting (and lack of systematic studies using defined tools), or by selection in trials for patients lacking comorbidities or coprescribed medications, or simply represent confounding by numerous other causes of muscle aches [15].…”

“…Symptomatic myalgia is defined as muscle aches not accompanied by raised creatine kinase levels [5,14]. It refers to muscular symptoms such as pain, ache and soreness, weakness (which might be confirmed by physical examination), and cramps.…”

Statins in Peripheral Arterial Disease

“…As previously mentioned, moderate doses of statin therapy have been associated with myopathy, liver disease, increased incidence of diabetes development and cognitive impairment. In randomized clinical trials, however, myalgia -the most common adverse effect following statin use -has shown similar presentation in both statin and placebo groups (90). The European Atherosclerosis Society consensus panel recommends that, in the presence of muscle pain or weakness, creatine kinase levels should be obtained and, in case that the levels are elevated, statins should be discontinued and subsequently restarted at a lower dose.…”