Statin use is associated with early recovery of kidney injury after vascular surgery and improved long-term outcome

Welten, Gijs M.J.M.; Chonchol, Michel; Schouten, Olaf; Hoeks, Sanne E.; Bax, Jeroen J.; Domburg, Ron T. van; Sambeek, Marc van; Poldermans, Don

doi:10.1093/ndt/gfn381

Cited by 63 publications

(55 citation statements)

References 28 publications

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“…This is also true for statins. First reports on its usefulness were not supported by the following studies [168][169][170][171] . It has been known since 2001 that low-dose dopamine is not justified for the prevention and treatment of AKI [172,173] .…”

Section: Pharmacological Interventionsmentioning

confidence: 90%

Serum creatinine role in predicting outcome after cardiac surgery beyond acute kidney injury

Najafi

2014

WJC

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Serum creatinine is still the most important determinant in the assessment of perioperative renal function and in the prediction of adverse outcome in cardiac surgery. Many biomarkers have been studied to date; still, there is no surrogate for serum creatinine measurement in clinical practice because it is feasible and inexpensive. High levels of serum creatinine and its equivalents have been the most important preoperative risk factor for postoperative renal injury. Moreover, creatinine is the mainstay in predicting risk models and risk factor reduction has enhanced its importance in outcome prediction. The future perspective is the development of new definitions and novel tools for the early diagnosis of acute kidney injury largely based on serum creatinine and a panel of novel biomarkers.

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Section: Pharmacological Interventionsmentioning

confidence: 90%

Serum creatinine role in predicting outcome after cardiac surgery beyond acute kidney injury

Najafi

2014

WJC

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“…17 In reality, patients with symptomatic PAD are at particularly high risk for having CKD. Feringa et al, 2 found that in patients with decreased (50.9) ankle-brachial index (ABI), 42% had mild, 22% had moderate and 3% had severe chronic kidney disease, amounting about two-thirds of patients with PAD, and statin use and ACEI has been reported to decrease or to slow the progression of CKD in these patients.…”

Section: Discussionmentioning

confidence: 99%

Low levels of high-density lipoproteins are associated with acute kidney injury following revascularization for chronic limb ischemia

Arora¹,

Davari-Farid²,

Gannon³

et al. 2013

Renal Failure

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.001) were independently associated with increased odds for developing AKI. Propensity score analyses showed low HDL was independently associated with increased odds of AKI (OR 2.4 (1.4-4.2)). Conclusions: AKI following revascularization is not uncommon (12.0%), and lower concentrations of HDL and serum albumin are associated with increased odds of postoperative AKI. There was also a trend of higher prevalence of AKI among those with pre-existing CKD.

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“…Some observational studies have shown that statins are associated with less AKI, whereas others have not. [15][16][17][18][19][20][21] Their potential benefit in the perioperative setting has also been shown in some small randomized controlled trials where administration of statins preopera-tively improved cardiovascular outcomes. 22,23 To examine the issue further and to inform the conduct of definitive randomized controlled trials, we studied all older patients who underwent major elective surgery in Ontario, the largest province in Canada, over a 14-year period.…”

mentioning

confidence: 89%

Statin Use Associates with a Lower Incidence of Acute Kidney Injury after Major Elective Surgery

Molnar

Coca

Devereaux

et al. 2011

Journal of the American Society of Nephrology

111

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Statins abrogate ischemic renal injury in animal studies but whether they are renoprotective in humans is unknown. We conducted a population-based retrospective cohort study that included 213,347 older patients who underwent major elective surgery in the province of Ontario, Canada from 1995 to 2008. During the first 14 postoperative days, 1.9% (4020 patients), developed acute kidney injury and 0.5% (1173 patients), required acute dialysis. The 30-day mortality rate was 2.8% (5974 patients). Prior to surgery, 32% of patients were taking a statin. After statistical adjustment for patient and surgical characteristics, statin use associated with 16% lower odds of acute kidney injury (OR, 0.84; 95% CI, 0.79 to 0.90), 17% lower odds of acute dialysis (OR, 0.83; 95% CI, 0.72 to 0.95), and 21% lower odds of mortality (OR, 0.79; 95% CI, 0.74 to 0.85). Propensity score matching produced similar results. These data suggest that statins may protect against renal complications after major elective surgery and reduce perioperative mortality.

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Statin use is associated with early recovery of kidney injury after vascular surgery and improved long-term outcome

Abstract: Statin use is associated with improved recovery from AKI after major surgery and has a beneficial effect on long-term survival.

Cited by 63 publications

References 28 publications

Serum creatinine role in predicting outcome after cardiac surgery beyond acute kidney injury

Serum creatinine role in predicting outcome after cardiac surgery beyond acute kidney injury

Low levels of high-density lipoproteins are associated with acute kidney injury following revascularization for chronic limb ischemia

Statin Use Associates with a Lower Incidence of Acute Kidney Injury after Major Elective Surgery

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