Statins everyday versus alternate days: Is there a difference in myalgia rates?

Abstract

ADD regime was better tolerated by the patients than EDD regime. Alternate day therapy, with or without vitamin D supplementation, may be used by the physicians for troublesome muscular complains.

Geranylgeraniol prevents statin-induced skeletal muscle fatigue without causing adverse effects in cardiac or vascular smooth muscle performance

“…5,6 Nonetheless, the onset of these conditions is a significant contributor to statin noncompliance, 7 and thus, a considerable obstacle for improving cardiovascular outcomes. 8 Currently in clinical practice, several strategies are employed to manage SAMS, including lower dose/ alternate-day dosing, 9,10 vitamin D repletion, 11 and coenzyme Q10 (CoQ10) supplementation. 12 While these methods can be effective for alleviating SAMS, they do have limitations.…”