Statins reduce endogenous dolichol levels in the neuroblastoma cell line SH-SY5Y

Atil, Bihter; Sieczkowski, Evelyn; Hohenegger, M

doi:10.1186/2050-6511-13-s1-a51

Cited by 3 publications

(3 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The disruption of this interaction can lead to the breakdown of skeletal muscle structure. Interestingly, simvastatin treatment decreased the endogenous dolichol level in neuroblastoma cells potentially influencing glycosylation [77]. Furthermore, a reduced dolichol level correlated with the apoptotic potential of simvastatin in this study.…”

Section: Synthesis Of Isoprenoidsmentioning

confidence: 60%

The Effects of Statin Medications on Aerobic Exercise Capacity and Training Adaptations

Murlasits

Radák

2014

Sports Med

View full text Add to dashboard Cite

The incidence of myopathy increases dramatically in statin users who also exercise, likely limiting the positive impact of this lifesaving medication. New evidence also indicates that statin use can directly compromise aerobic exercise capacity; however, we are just beginning to understand the interactions of statins with exercise training and adaptations. This review focuses on the interactions of statins with aerobic exercise capacity and training adaptations to summarize the available information and draw attention to the gaps in our current knowledge in this area. PubMed, Web of knowledge, and Google scholar databases were searched between January 2000 and December 2013 using the following terms and their combinations: statins, exercise, aerobic capacity, endurance training, adaptations. The reference lists of the relevant articles were also scanned for additional information. Considering the widespread use of statins and the need for exercise for cardiovascular health, a better understanding of the interactions of these interventions as well as practical solutions are needed to reduce statin adverse effects associated with exercise.

show abstract

Section: Synthesis Of Isoprenoidsmentioning

confidence: 60%

The Effects of Statin Medications on Aerobic Exercise Capacity and Training Adaptations

Murlasits

Radák

2014

Sports Med

View full text Add to dashboard Cite

show abstract

“…Being neuronal cells, SH-SY5Y cells may be more sensitive to the effects of this drug, explaining these differences between cell lines. Indeed, in a study, statins demonstrated to induce apoptosis in SH-SY5Y cells by reducing the levels of dolichol, required for the biosynthesis of biologically important N-linked glycoproteins [ 21 ].…”

Section: Resultsmentioning

confidence: 99%

Atorvastatin and Nitrofurantoin Repurposed in the Context of Breast Cancer and Neuroblastoma Cells

et al. 2023

View full text Add to dashboard Cite

Chemotherapy still plays a central role in the treatment of cancer. However, it is often accompanied by off-target effects that result in severe side-effects and development of drug resistance. The aim of this work was to study the efficacy of different repurposed drugs on the viability of MCF-7 and SH-SY5Y breast cancer and neuroblastoma cells, respectively. In addition, combinations of these repurposed drugs with a classical chemotherapeutic drug (doxorubicin) were also carried out. The cytotoxic effects of the repurposed drugs were evaluated individually and in combination in both cancer cell lines, assessed by MTT assays and morphological evaluation of the cells. The results demonstrated that atorvastatin reduced the viability of both cell lines. However, nitrofurantoin was able to induce cytotoxic effects in MCF-7 cells, but not in SH-SY5Y cells. The combinations of the repurposed drugs with doxorubicin induced a higher inhibition on cell viability than the repurposed drugs individually. The combination of the two repurposed drugs demonstrated that they potentiate each other. Synergism studies revealed that the combination of doxorubicin with the two repurposed drugs was more effective in SH-SY5Y cells, compared to MCF-7 cells. Taken together, our preliminary study highlights the potential use of atorvastatin and nitrofurantoin in the context of breast cancer and neuroblastoma.

show abstract

“…For example, in a study in these cells, simvastatin stimulated the production of the antiapoptotic protein Bcl-2 via endothelin-1 and nuclear factor of activated thymocytes 3 [ 31 ]. Another study with simvastatin also highlighted the apoptotic mechanism of this drug on SH-SY5Y cells by reducing the levels of dolichol, influencing glycosylation process in the endoplasmic reticulum [ 32 ].…”

Section: Resultsmentioning

confidence: 99%

The Involvement of Hypoxia in the Response of Neuroblastoma Cells to the Exposure of Atorvastatin

Correia

Marques

Vale

2023

CIMB

View full text Add to dashboard Cite

Cancer is a set of complex diseases, being one of the leading causes of death worldwide. Despite a lot of research on the molecular pathways and effective treatments, there are still huge gaps. Indeed, the development of new anti-cancer drugs is a complex process. To face this problem, drug repurposing is being increasingly applied. This approach aims to identify new indications for already approved drugs. In this regard, statins (clinically used for reducing cholesterol levels) are reported to induce anti-cancer effects, particularly by inducing apoptosis and altering the tumor microenvironment. Atorvastatin is a type of statin with several potentialities as an anti-cancer agent, supported by several studies. Our study aimed to explore the effect of this drug in SH-SY5Y human neuroblastoma cells. Additionally, we also aimed to understand how this drug acts under hypoxia and the inhibition of hypoxia-inducible factor-1 (HIF-1). For that purpose, we assessed cellular viability/morphology after exposure to different concentrations of atorvastatin, with or without chemically induced hypoxia with chloride cobalt (CoCl2) and with or without echinomycin (HIF-1α inhibitor). Our results supported the cytotoxic effects of atorvastatin. Additionally, we also revealed that besides these effects, under hypoxia, this drug induced proliferation of the neuroblastoma cells, supporting the importance of different stimuli and environment on the effect of drugs on cancer cells.

show abstract

Statins reduce endogenous dolichol levels in the neuroblastoma cell line SH-SY5Y

Cited by 3 publications

References 1 publication

The Effects of Statin Medications on Aerobic Exercise Capacity and Training Adaptations

The Effects of Statin Medications on Aerobic Exercise Capacity and Training Adaptations

Atorvastatin and Nitrofurantoin Repurposed in the Context of Breast Cancer and Neuroblastoma Cells

The Involvement of Hypoxia in the Response of Neuroblastoma Cells to the Exposure of Atorvastatin

Contact Info

Product

Resources

About