Statins Regulate IL-1β - Induced RANKL and OPG Production by Human Gingival Fibroblasts

Pleiotropic effects of statins on the treatment of chronic periodontitis – a systematic review

“…In these cells, atorvastatin increased up to three times the production of mRNA of OPG . It was also verified that, in inflammatory conditions, the production of OPG by human gingival fibroblasts can be increased up to 10 times .…”

Association of serum lipid indices and statin consumption with periodontal status

“…Periodontal disease is a chronic inflammatory disease characterized by the release of cytokines such as TNF‐ α and IL‐1 β (Valentaviciene et al , ; Jurkowski, ; Singh et al , ; Fernandez et al , ). Evidence shows that serum and gingival crevicular fluid pro‐inflammatory cytokines such as IL‐6, IL‐1 β , and TNF‐ α may be responsible for the association of periodontal disease and hyperlipidemia (Fentoğlu et al , ,b; Fentöglu et al , ).…”

“…Statins are lipid‐lowering drugs with pleiotropic and anabolic effects; they enhance the bone morphogenetic protein‐2 and vascular endothelial growth factor mRNA levels (Fajardo et al , ; Singh et al , ; Suresh and Jayakumar, ; Hernandez et al , ). They also possess anti‐inflammatory properties and inhibit the release of cytokines such as matrix metalloproteinase‐1 (MMP‐1), MMP‐2, MMP‐3, MMP‐9 (Saxlin et al , ; Fajardo et al , ), IL‐1, IL‐6, and IL‐8 (Jurkowski, ; Singh et al , ; Fernandez et al , ); consequently, they prevent tissue destruction and have antiresorptive activity by blocking the mevalonate pathway and interfering with vesicular fusion and formation of the ruffled border in osteoclasts (Jurkowski, ; Singh et al , ; Suresh and Jayakumar, ).…”