Statins-related peripheral neuropathy among diabetic patients

Hammad, Mohamed; Sulaiman, Syed Azhar Syed; Alghamdi, Saleh; Mangi, Altaf Ali; Aziz, Nor Azizah; Noor, Dzul Azri Mohamed

doi:10.1016/j.dsx.2020.04.005

Cited by 11 publications

(8 citation statements)

References 27 publications

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“…Other serious complications have been reported, including arrhythmia, septic shock, and multi-organ failure ( Arentz et al, 2020 , Chen et al, 2020 ). Older persons with comorbidities and polypharmacy have a higher risk for drugs interactions, side effects, complications and high probability of viral infection ( Hammad et al, 2020 , Hammad et al, 2019b , Hammad et al, 2019a , Hammad et al, 2017 , Mangi et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics and treatment outcomes of severe (ICU) COVID-19 patients in Saudi Arabia: A single centre study

Alghamdi¹

2021

Saudi Pharmaceutical Journal

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Background There is limited information describing the presenting features and treatment outcomes of intensive care unit (ICU) patients with coronavirus disease 2019 (COVID-19) in Saudi Arabia. Objective To investigates the clinical, epidemiological, laboratory, radiological, vital signs and treatment characteristics/outcomes of severe (ICU) COVID-19 patients in Albaha region, Saudi Arabia. Methods A retrospective cohort study was conducted from 01 April 2020 to 31 August 2020 involving files review of 171 patients admitted to the ICU of a COVID-19 treatment centre as a result of severe symptoms. Results Around a third of the ICU patients admitted were over 66 years of age, 59.6% males, 45% diabetics, 39% hypertensive, 25.7% smokers. Patients had symptoms such as 79% fever, 78% cough, 75% headache, 59% sore throat, 57% runny nose, and 75% cough. More than half of the patients had less than 90% oxygen saturation. Bilateral infiltration was present in about 43% of patients. 85.4% lymphopenia, and 70.8% D-dimer (>0.5 u/ml) were the most significant laboratory results. The median stay in the hospital ranged from 4 to 15.6 days, and the ICU time ranged from 4 to 12.7 days. Approximately 29% of patients received antiviral, antimalarial, and antibiotic treatment, while 27.5% of patients received antibiotics and antimalarial therapy alone. Incorporating hydroxychloroquine in treatment protocols did not improve patients’ outcomes. Conclusions Older age and cardio-metabolic comorbidities increase the risks of sever COVID-19. Different treatment protocols fail to improve mortality rates and urgent efforts are required to prevent the disease and reduce its severity.

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Section: Introductionmentioning

confidence: 99%

Clinical characteristics and treatment outcomes of severe (ICU) COVID-19 patients in Saudi Arabia: A single centre study

Alghamdi¹

2021

Saudi Pharmaceutical Journal

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“…Statins can cause neuropathy, and impaired mitochondrial transport and a reduction in vitamin E levels have been proposed as underlying mechanisms[ 16 ]. An analysis of 757 patients with diabetes revealed a significantly greater relative risk of peripheral neuropathy in patients with diabetes who were receiving statin therapy[ 6 ]. Our results included a larger sample size than in previous studies and confirmed the elevated risk of neuropathy in patients with T2DM during statin therapy.…”

Section: Discussionmentioning

confidence: 99%

“…hydroxymethylglutaryl-CoA reductase inhibitors) are used as first-line therapy for dyslipidemia[ 3 ]. Despite their broad usage, some studies have shown that statins may induce neuropathy[ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Impacts of statin and metformin on neuropathy in patients with type 2 diabetes mellitus: Korean Health Insurance data

Min¹,

Kim²,

Choi³

et al. 2021

WJCC

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BACKGROUND Neuropathy is a common chronic complication in type 2 diabetes mellitus (T2DM). Statin and metformin are commonly used medications in T2DM patients, and some studies showed statin- or metformin-induced neuropathy. AIM To evaluate the incidence of neuropathy among patients with T2DM associated with statin and metformin therapies. METHODS Korean Health Insurance Review and Assessment national patient sample data from 2016 and 2017 were used. Patients with T2DM and no complications were divided into statin/metformin/statin + metformin users and non-users. Neuropathy incidence was defined by International Statistical Classification of Diseases and Related Health Problems, 10 th revision codes and concomitant prescriptions for anticonvulsants or antidepressants. Logistic regression analyses were conducted to examine the associations between statin/metformin/statin + metformin therapies and the incidence of neuropathy. Propensity score (PS) matching was performed on the basis of age, sex and comorbidities. RESULTS Overall, 34964 and 35887 patients with T2DM and no complications were included in the Korean Health Insurance Review and Assessment national patient sample datasets from 2016 and 2017, respectively. Statin therapy was associated with increased risks of neuropathy in 2016 and 2017 [PS-matched odds ratio (OR) = 1.22, 95% confidence interval (CI): 1.08-1.38; PS-matched OR = 1.17, 95%CI: 1.03-1.33, respectively]. Metformin therapy was associated with reduced risks of neuropathy in 2016 and 2017 (PS-matched OR = 0.30, 95%CI: 0.21-0.42; PS-matched OR = 0.44, 95%CI: 0.32-0.60, respectively). Combined statin + metformin therapy was not significantly associated with neuropathy in 2016 or 2017 (PS-matched OR = 0.85, 95%CI: 0.61-1.19; PS-matched OR = 0.95, 95%CI: 0.66-1.38, respectively). CONCLUSION Statin therapy was associated with enhanced risk of new-onset neuropathy in patients with T2DM, but metformin therapy showed the opposite association.

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“…The total weighted point predominance of PIMU in nursing homes was 43.2% (95% CI: 0.37-0.49), rising from 30.3% in studies conducted throughout 1990-1999 to 49.8% in studies carried out after 2005 (P < 0.001). Point prevalence estimation documented in [30][31][32] The current study encompasses a big sample size in a tertiary hospital. The study revealed the inappropriate medications among the elderly, in various therapy categories.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the geriatric patients prescription for inappropriate medications frequency at Larkana Sindh Hospital in Pakistan

Mangi

Hammad

Khan

et al. 2020

Clinical Epidemiology and Global Health

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Background: Aging is the irreversible change in the human physiology which occurs with the passage of time and it becomes very much critical to recommend drugs among the geriatrics patients because their body response is quite different. Objectives: The purpose of the current study is to assess and evaluate the potentially inappropriate medications among the geriatric patients at the tertiary care Hospital of Larkana Sindh which is the biggest Hospital in the Northern Part of Sindh. Methods: The descriptive cross-sectional study was conducted which included the 500 patients aged more than 60 years. The data was collected from the patients' case charts and the questionnaire distributed among the patients. BEERS′ criteria was used to detect the frequency of chronic disorders in geriatric patients and appraise the polypharmacy. Results: The male patients were 42.6% and the female patients were 57.4%. The inappropriate medication use (IMU) was observed among 22.6% patients. Inappropriate antibiotics were seen in 35.39%, Benzodiazepine 28.32%, non-steroidal anti-inflammatory drugs (NSAIDs) 15.04%, cardiovascular system (CVS) drugs 12.39% of patients. Parenteral route of administration was observed in 70.04% of patients. Conclusion: Polypharmacy is highly prevalent in the prescriptions of geriatrics patients, due to certain reasons like a chronic disease. Clinical Pharmacist can be better placed to provide his professional activities in this context.

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Statins-related peripheral neuropathy among diabetic patients

Cited by 11 publications

References 27 publications

Clinical characteristics and treatment outcomes of severe (ICU) COVID-19 patients in Saudi Arabia: A single centre study

Clinical characteristics and treatment outcomes of severe (ICU) COVID-19 patients in Saudi Arabia: A single centre study

Impacts of statin and metformin on neuropathy in patients with type 2 diabetes mellitus: Korean Health Insurance data

Evaluation of the geriatric patients prescription for inappropriate medications frequency at Larkana Sindh Hospital in Pakistan

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