Statistical analysis of data for three British ethnic groups  from a new STR multiplex

Evett, I.W.; Gill, Peter; Lambert, J.A.; Oldroyd, Nicola J.; Frazier, R.; Watson, Steve P.; Panchal, Sasikala; Connolly, Alexandra; Kimpton, C.

doi:10.1007/pl00007701

Cited by 23 publications

(31 citation statements)

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“…Table 2 gives PM values calculated from the SGM-plus data. Figures obtained at the SGM loci are virtually indistinguishable from those reported in Table 2 of Evett et al (1997) and comparison of both tables reveals the increased discriminating power attainable under the SGM-plus profiling system; i.e. PM values are of the order 1 in 100 million for SGM as compared with 1 in 10,000 billion for SGM-plus.…”

Section: Allele Distributions and Discriminating Powermentioning

confidence: 46%

“…Allele proportions estimated at the six SGM loci from the original FSS SGM frequency databases are tabulated in Evett et al (1997). As would be expected, these agree closely with the corresponding estimates obtained using the SGM-plus databases; e.g.…”

Section: Allele Distributions and Discriminating Powermentioning

confidence: 74%

“…With particular reference to the STR loci used in the SGM-plus system, results of within-and between-locus independence testing have already been reported: SGM loci (Evett et al 1997), SGM loci plus D3 and D16 (Ga- (Watson et al 2000). These papers add to the existing body of literature which, to date, has found little evidence refuting the validity of multiplying match probabilities across loci.…”

Section: A Foreman · I W Evettmentioning

confidence: 88%

“…A proportion of the SGM-plus samples are also present on the SGM frequency databases analysed in Evett et al (1997), as indicated below: Inclusion of these data in our analyses facilitated within-racial group comparisons of allele distributions and match probabilities when considered alongside the FSS databases.…”

Section: Methodsmentioning

confidence: 99%

“…As part of the statistical validation of the current SGM system (Evett et al 1997), independence tests were carried out on the three main FSS frequency databases, although the authors made clear their reservations about the relevance of such testing. However, with the introduction of the new SGM-plus system, it is our view that routine independence testing of DNA frequency databases should be abandoned; our reasons can be summarised as follows:…”

Section: A Foreman · I W Evettmentioning

confidence: 99%

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Statistical analyses to support forensic interpretation for a new ten-locus STR profiling system

Foreman¹,

Evett²

2001

International Journal of Legal Medicine

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A new ten-locus STR (short tandem repeat) profiling system was recently introduced into casework by the Forensic Science Service (FSS) and statistical analyses are described here based on data collected using this new system for the three major racial groups of the UK: Caucasian. Afro-Caribbean and Asian (of Indo-Pakistani descent). Allele distributions are compared and the FSS position with regard to routine significance testing of DNA frequency databases is discussed. An investigation of match probability calculations is carried out and the consequent analyses are shown to provide support for proposed changes in how the FSS reports DNA results when very small match probabilities are involved.

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Section: Allele Distributions and Discriminating Powermentioning

confidence: 46%

Section: Allele Distributions and Discriminating Powermentioning

confidence: 74%

Section: A Foreman · I W Evettmentioning

confidence: 88%

Section: Methodsmentioning

confidence: 99%

Section: A Foreman · I W Evettmentioning

confidence: 99%

See 3 more Smart Citations

Statistical analyses to support forensic interpretation for a new ten-locus STR profiling system

Foreman¹,

Evett²

2001

International Journal of Legal Medicine

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Microsatellite variation in Central Africa: An analysis of intrapopulational and interpopulational genetic diversity

Destro-Bisol

Boschi

Caglià

et al. 2000

Am. J. Phys. Anthropol.

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As a part of a research project on molecular variation in Central Africa, we have analyzed 10 microsatellites (CD4, CSFO, D3S1358, D18S51, D21S11, F13A1, FES, TH01, TPOX, and VWA) in the Bamileke and Ewondo from Cameroon and the Sanga and Mbenzele Pygmies from the Central African Republic (a total of 390 chromosomes). A statistically significant trend towards heterozygote deficiency was detected in the Mbenzele Pygmies. This was established through the use of powerful exact tests for the Hardy-Weinberg equilibrium. A certain degree of isolation and a small effective size may explain this finding. However, the lack of any substantial reduction in allelic diversity in the Mbenzele does not support the possibility that this group has a smaller effective size in evolutionary terms. A possible explanation based on ethnographic studies suggests that the gene flow from non-Pygmies to Pygmies could have been interrupted only in relatively recent times. The analysis of association between genotypes at pairs of independent loci indicates that the level of subheterogeneity is markedly lower in the Bamileke than in other sampled populations. This may be explained by the combined effect of larger population size, more rigid respect of clanic exogamy, and higher matrimonial mobility of the Bamileke. Finally, we have analyzed interpopulational relationships among our sampled populations and other Central African populations. The results are consistent with a previous study of protein loci (Spedini et al. 1999), which suggests the recent history of the Bamileke and Ewondo has led them to aquire a substantial genetic similarity. Furthermore, the Mbenzele Pygmies diverge from Biaka Pygmies, despite their common origin and geographical proximity. This is probably due to the differentiating effect of genetic drift, which is enhanced by the small effective size of Pygmy populations.

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Likelihood ratios for evaluating DNA matches obtained from a database search when there is substructure in the population

Spooner

Stockmarr

2019

Statistics in Medicine

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DNA database searches are frequently conducted to identify the suspects of crimes. When a match is obtained from such a database search, the evidence must be evaluated. Existing methods for assessment of the DNA evidence in this scenario require assumption of stochastic independence between the profiles in the database. However, when there is substructure in the population, this assumption is violated. The problem of how to account for population substructure in the database search scenario is analyzed and a solution in the form of a bounded estimate for the likelihood ratio is presented. The implications of these methods are investigated in a realistic scenario using published forensic allele frequencies to simulate ten-locus DNA profiles. In the simulated example, it is observed that the strength of the evidence can be inflated by more than a factor of 10 in 11.6% of database search cases if mild population substructure is ignored. With these methods, the magnitude of the subpopulation effect in the database search scenario can be quantified and the weight of the evidence of a DNA match more accurately assessed. KEYWORDSdatabase search, DNA profiling, likelihood ratio, population substructure 5010

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Statistical analysis of data for three British ethnic groups from a new STR multiplex

Cited by 23 publications

References 0 publications

Statistical analyses to support forensic interpretation for a new ten-locus STR profiling system

Statistical analyses to support forensic interpretation for a new ten-locus STR profiling system

Microsatellite variation in Central Africa: An analysis of intrapopulational and interpopulational genetic diversity

Likelihood ratios for evaluating DNA matches obtained from a database search when there is substructure in the population

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