Statistical analysis of trace metals in the plasma of cancer patients versus controls

Pasha, Qaisara; Malik, Salman Akbar; Shah, Munir H.

doi:10.1016/j.jhazmat.2007.09.115

Cited by 60 publications

(55 citation statements)

References 61 publications

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“…Similarly, in the plasma of healthy humans, a negative association between Cd and Cu was reported (Pasha et al 2008). Cu deficiency or that low levels of Zn in the diet lead to Cu accumulation and Cu toxicity in ruminants (Mills and Dalgarno 1972), pigs (Poulsen 1998) and laboratory animals (Blalock et 1988;Hall et al 1979).…”

Section: Discussionmentioning

confidence: 91%

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Influence of organic selenium supplementation on the accumulation of toxic and essential trace elements involved in the antioxidant system of chicken

Pappas

Zoidis

Georgiou

et al. 2011

Food Additives & Contaminants: Part A

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Section: Discussionmentioning

confidence: 91%

“…Several studies have confirmed that Fe and Cu are associated (Gambling et al 2008;Pasha et al 2008). Copper -Fe interactions may occur either at the level of intestinal absorption (Gambling et al 2008) or during transportation by the DMT1 (divalent metal transporter 1) (Garrick et al 2003).…”

Section: Discussionmentioning

confidence: 99%

Influence of organic selenium supplementation on the accumulation of toxic and essential trace elements involved in the antioxidant system of chicken

Pappas

Zoidis

Georgiou

et al. 2011

Food Additives & Contaminants: Part A

View full text Add to dashboard Cite

“…Pearson correlation analysis was used to investigate the mutual relations between each pair of TEs. In addition, a multivariate technique of PCA [21] was used to fi nd the possible sources and grouping of studied elements in the scalp hair of leukaemia patients and compare these results with those obtained for the control group. All calculations were performed using statistical packages STATISTICA-8 [22].…”

Section: Discussionmentioning

confidence: 99%

Trace elements in scalp hair of leukaemia patients

et al. 2014

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Abstract. The aim of this study was to determine the concentration of Fe, Ni, Cu, Zn and Pb in scalp hair of leukaemia patients and healthy volunteers, using the optimised XRF method. Leukaemia hair samples were classifi ed corresponding to type, growth and age of the participants. The results showed that the studied trace elements (TEs) in both of leukaemia and control groups were positively skewed. In comparison with the control group, lower Fe, Cu, Zn and Pb and higher of Ni medians were found in all studied leukaemia patients. The median rank obtained by Mann-Whitney U-test revealed insignifi cant differences between the leukaemia patients subgroups and the controls. An exact probability ( < 0.05) associated with the U-test showed signifi cant differences between medians in leukaemia patients and controls groups for Pb (lymphatic/control, acute/control), Cu (lymphatic/control, chronic/control), Ni (lymphatic/control, chronic/control) and Fe (chronic/control). Very strong positive and negative correlations (r > 0.70) in the scalp hair of control group were observed between Ni/Fe-Ni, Cu/Fe-Cu, Zn/Fe-Zn, Pb/Fe-Pb, Cu/Ni-Zn/Ni, Cu/Ni-Pb/Ni, Zn/Ni-Pb/Ni, Zn/Fe-Zn/Cu, Pb/Ni-Ni and Ni/Fe-Pb/Ni, whereas only very strong positive ratios in the scalp hair of leukaemia patients group were observed between Ni/Fe-Ni, Cu/Fe-Cu, Zn/Fe-Zn and Pb/Fe-Pb, all correlations were signifi cant at p < 0.05. Other strong and signifi cant correlations were also observed in scalp hair of both groups. Signifi cant differences between grouping of studied TEs in all classifi ed leukaemia groups and controls were found using principal component analysis (PCA). The results of PCA confi rmed that the type and the growth of leukaemia factors were more important in element loading than the age factor.

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“…Pasha et al (2008) reported higher concentration of manganese, magnesium and plumbum in plasma of prostate cancer patients as compared to controls (Pasha et al, 2008). Manganese is an essential trace element in the body which has several biochemical and chemical properties similar to iron.…”

Section: Discussionmentioning

confidence: 99%

Association between Trace Element and Heavy Metal Levels in Hair and Nail with Prostate Cancer

Karimi¹,

Shahar²,

Homayouni³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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While associations between trace elements and heavy metals with prostate cancer are still debatable, they have been considered as risk factors for prostate cancer. Thus, this study aimed to detect any links between selected minerals and heavy metals including Se, Zn, Cu, Mn and Fe with prostate cancer. A case control study was carried out among 100 subjects (case n=50, control n=50), matched for age and ethnicity. Trace elements and heavy metals level in hair and nail samples were determined by ICP-MS. Mean selenium levels in hair and nail of the cases were significantly lower as compared to controls. A similar trend was noted for zinc in both hair and nail samples, whereas the mean level of copper was significantly higher in cases than controls. Similar elevation was noted for iron and manganese (p<0.05 for all parameters). Low levels of selenium and zinc and high levels of copper, iron and manganese appear to be associated with the risk of prostate cancer. Further studies to elucidate the causal mechanisms and appropriate chemopreventive measures are needed.

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Statistical analysis of trace metals in the plasma of cancer patients versus controls

Cited by 60 publications

References 61 publications

Influence of organic selenium supplementation on the accumulation of toxic and essential trace elements involved in the antioxidant system of chicken

Influence of organic selenium supplementation on the accumulation of toxic and essential trace elements involved in the antioxidant system of chicken

Trace elements in scalp hair of leukaemia patients

Association between Trace Element and Heavy Metal Levels in Hair and Nail with Prostate Cancer

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