Statistical and network-based analysis of Italian COVID-19 data: communities detection and temporal evolution

Milano, Marianna; Cannataro, Mario

doi:10.1101/2020.04.17.20068916

Cited by 8 publications

(9 citation statements)

References 13 publications

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“…Although SARS-CoV-2 is similar to other known coronaviruses, i.e. SARS-CoV and MERS-CoV ( Perlman and Netland, 2009 ; de Groot et al, 2013 ; Weber et al, 2021 ), it has demonstrated high rates of infection ( Liu et al, 2020 ; Surveillances, 2020 ; Milano and Cannataro, 2020 ). Hence, there is a need to understand the disease pathogenesis of SARS-CoV-2 to develop effective therapies and vaccines.…”

Section: Introductionmentioning

confidence: 99%

Analyzing host-viral interactome of SARS-CoV-2 for identifying vulnerable host proteins during COVID-19 pathogenesis

Das

Roy

Guzzi

2021

Infection, Genetics and Evolution

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The development of therapeutic targets for COVID-19 treatment relies on understanding the molecular mechanism of pathogenesis. Identifying genes and proteins involved in the infection mechanism is the key to shedding light on the complex molecular mechanisms. The combined effort of many laboratories distributed throughout the world has produced protein and genetic interactions. We integrated available results and obtained a host protein-protein interaction network composed of 1432 human proteins. Next, we performed network centrality analysis to identify critical proteins in the derived network. Finally, we performed a functional enrichment analysis of central proteins. We observed that the identified proteins are primarily associated with several crucial pathways, including cellular process, signaling transduction, neurodegenerative diseases. We focused on the proteins that are involved in human respiratory tract diseases. We highlighted many potential therapeutic targets, including RBX1, HSPA5, ITCH, RAB7A, RAB5A, RAB8A, PSMC5, CAPZB, CANX, IGF2R, HSPA1A, which are central and also associated with multiple diseases.

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Section: Introductionmentioning

confidence: 99%

Analyzing host-viral interactome of SARS-CoV-2 for identifying vulnerable host proteins during COVID-19 pathogenesis

Das

Roy

Guzzi

2021

Infection, Genetics and Evolution

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“…This means that the Italian regions behaved differently with respect to ten different data provided by civil protection. Further analysis about communities in Italian COVID-19 data and their temporal evolution can be found in [ 9 ], where a sequential version of this methodology has been used.…”

Section: Resultsmentioning

confidence: 99%

A New Parallel Methodology for the Network Analysis of COVID-19 Data

Agapito

Milano

Cannataro

2021

Euro-Par 2020: Parallel Processing Workshops

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Coronavirus disease (COVID-19) outbreak started at Wuhan, China, and it has rapidly spread across the world. In this article, we present a new methodology for network-based analysis of Italian COVID-19 data. The methodology includes the following steps: (i) a parallel methodology to build similarity matrices that represent similar or dissimilar regions with respect to data; (ii) the mapping of similarity matrices into networks where nodes represent Italian regions, and edges represent similarity relationships; (iii) the discovering communities of regions that show similar behaviour. The methodology is general and can be applied to world-wide data about COVID-19. Experiments was performed on real datasets about Italian regions, and they although the limited size of the Italian COVID-19 dataset, a quite linear speed-up was obtained up to six cores.

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“…Moreover, in a survey conducted by the European Society of Cataract and Refractive Surgeons (ESCRS), almost 80% of the Greek participants reported performing no surgeries at all during the lockdown period, compared with approximately 50% of those in Italy, while Italy was one of the most affected European countries bearing one of the highest death rates from COVID-19. 3,4 Cataract surgery, as one of the most common elective operations performed worldwide, was postponed during COVID-19 pandemic in most European and American countries in an attempt to reduce the risk of spreading the infection. 3,4 Another approach though, regarding the management of cataract surgeries, comes from Hong Kong where the continuation of elective cataract surgeries during the COVID-19 pandemic was proposed.…”

Section: Introductionmentioning

confidence: 99%

“…3,4 Cataract surgery, as one of the most common elective operations performed worldwide, was postponed during COVID-19 pandemic in most European and American countries in an attempt to reduce the risk of spreading the infection. 3,4 Another approach though, regarding the management of cataract surgeries, comes from Hong Kong where the continuation of elective cataract surgeries during the COVID-19 pandemic was proposed. 5 This recommendation was done under some conditions such as low community transmission in the area, the need for local anaesthesia, which is the case in phacoemulsification, and the existence of a long waiting list.…”

Section: Introductionmentioning

confidence: 99%

The impact of COVID-19 lockdown on cataract surgery: a surgeons’ perspective

Tzamalis

Karafotaki

Karipidi

et al. 2021

Clinical and Experimental Optometry

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Clinical relevance: In the last months, the whole world is dealing with an unprecedented public health crisis due to COVID-19 outbreak. Consequently, many governments have implemented lockdowns on a national level, affecting, among others, ophthalmic surgical practice in a globe scale. Background: The aim of this study is to evaluate the impact of surgical theatre lockdown due to COVID-19 pandemic on the surgical performance of cataract surgeons. Methods: Intraoperative complications and surgical time of the first 160 cataract surgeries performed by eight consultants (20 cases each) after a two-month lockdown were recorded and analysed in a cross-sectional study. The results were plotted against the last 30 cases of each surgeon before the implementation of the lockdown (240 cases). Cataract surgeons were asked to rate their subjective perspective and difficulties faced after reopening through a questionnaire. Results: The average duration of all surgeries after the lockdown was 19.1 ± 6.2 minutes showing a 14% increase compared to the one before the lockdown (16.8 ± 5.1 minutes, p = 0.0001). The complications rate was 2.09% (5/240 cases) before the abstention and 3.12% (5/160 cases) after the abstention not yielding any statistically significant difference (p = 0.74). When complicated surgeries were excluded from the analysis, surgical time was still higher after the lockdown (18.9 ± 5.9 minutes) than before (16.6 ± 5.0 minutes, p < 0.0001). 37.5% of consultants (3/8) stated that the two-month abstention from cataract surgeries has affected their surgical skills somewhat or a lot, while 62.5% (5/ 8) reported being more careful in their first cases after the lockdown. Most complications occurred in the hands of one surgeon who stated to be very anxious upon restart. Conclusion: The operating theatres' lockdown due to COVID-19 pandemic did not seem to affect the intraoperative complications rate in cataract surgery. A slight increase of surgical duration was noted, while most surgeons reported being more careful upon restart.

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Statistical and network-based analysis of Italian COVID-19 data: communities detection and temporal evolution

Cited by 8 publications

References 13 publications

Analyzing host-viral interactome of SARS-CoV-2 for identifying vulnerable host proteins during COVID-19 pathogenesis

Analyzing host-viral interactome of SARS-CoV-2 for identifying vulnerable host proteins during COVID-19 pathogenesis

A New Parallel Methodology for the Network Analysis of COVID-19 Data

The impact of COVID-19 lockdown on cataract surgery: a surgeons’ perspective

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