Statistical method to assess usual dietary intakes in the European population

Vilone, Giulia; Comiskey, D.; Héraud, Fanny; O’Mahony, Cian

doi:10.1080/19440049.2014.955886

Cited by 8 publications

(4 citation statements)

References 11 publications

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“…To perform such an analysis, it is typical to combine contamination values and food consumption data to obtain an estimation of the exposure level [26]. The importance of understanding consumption patterns is encouraged by the European Food Safety Agency [27] since consumption plays a significant role in further impact assessment and enables estimations of different nutrients and food hazards on consumer health [28]. Exposure to AFM1 is a result of consuming milk and dairy products and high(er) milk/dairy consumptions are recognized as the most important factors by all demographic groups [4].…”

Section: Introductionmentioning

confidence: 99%

Aflatoxins in Milk and Dairy Products: Occurrence and Exposure Assessment for the Serbian Population

Đjekić

Petrović²,

Jovetić³

et al. 2020

Applied Sciences

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The main objective of this study was to assess the exposure associated with aflatoxin M1 (AFM1) of the adult population in Serbia from consumption of milk and dairy products. This assessment was performed using concentration values of AFM1 in raw milk (385 samples) and dairy products (556 samples) based on the analyses conducted in the period between 2015 and 2018. In parallel, a dairy products consumption survey was completed during 2018 based on ‘one-day’ and ‘seven-day’ recall methods. In order to estimate the intake of AFM1 from the consumption of dairy products for both recall methods, a Monte Carlo simulation was conducted. The study revealed that pasteurized milk and yogurt are dairy products mostly consumed by the Serbian adult population. Estimated daily intake of AFM1 was in the range of 62–74 × 10−3 ng/kg bw/day, depending on the recall methods and scenarios employed. Although the results show moderate exposure risks compared to similar studies worldwide, climatic conditions and weather extremes that have occurred recently may have negatively influenced the contamination of feed and, consequently, AFM1 contamination of milk. As a result, it is justifiable to promote continuous monitoring in feed and dairy supply chains in Serbia and provide an update of exposure assessment.

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Section: Introductionmentioning

confidence: 99%

Aflatoxins in Milk and Dairy Products: Occurrence and Exposure Assessment for the Serbian Population

Đjekić

Petrović²,

Jovetić³

et al. 2020

Applied Sciences

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“…However, EFSA encourages the use of probabilistic approaches to capture the variability in refined models (EFSA, 2011a). Therefore, food consumption patterns play a significant role in all risk assessment activities in order to estimate the impact of different nutrients and food hazards on consumer health (Vilone et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Exposure assessment of adult consumers in Serbia, Greece and Croatia to deoxynivalenol and zearalenone through consumption of major wheat-based products

Đjekić

Udovički

Kljusurić

et al. 2019

WMJ

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The main objective of this research was to perform an exposure assessment of mycotoxin intake through consumption of wheat-based products in Serbia, Croatia, and Greece by estimating deoxynivalenol (DON) and zearalenone (ZEA) exposure from wheat. Food consumption survey of wheat-based products has been performed during 2017 in the three countries with at least 1000 interviewees per country. Values for the concentration of DON and ZEA were extracted from available research published in this decade. Finally, a Monte Carlo analysis of 100,000 simulations was performed to estimate the intake of DON and ZEA from consumption of wheat-based products. Results revealed that the estimated daily wheat-borne intake of DON of the adult population in Croatia was 0.121 μg/kg bw/day, followed by Greece with 0.181 μg/kg bw/day and Serbia with 0.262 μg/kg bw/day. This shows that 0.25% of Croatian, 1.19% of Greek and 3.96% of Serbian adult population is exposed to higher daily dietary intakes of DON than recommended. Estimated daily wheat-borne intake of ZEA was 0.017 μg/kg bw/day in Greece, 0.026 μg/kg bw/day in Croatia and 0.050 μg/kg bw/day in Serbia. Higher intake of ZEA is associated with 0.62% of the Greek population, followed by 0.95% Croatian and 2.25% of Serbian citizens. This type of research is helpful to assess accurately the risk by DON/ZEA intake associated with the consumption of wheat-based products by consumers in these three countries. Distributions of potential mycotoxin intakes were highly right-skewed.

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“…To overcome this limitation a recent study was executed to assess how existing consumption data could be improved by developing a 'Compiled European Food Consumption Database' (Vilone et al, 2014). According to this study, this database provides a fundamental tool to perform exposure assessments at the European level.…”

Section: Main Challenges In Exposure Assessment To Multiple Mycotoxinsmentioning

confidence: 99%

Challenges in risk assessment of multiple mycotoxins in food

Assunção

Silva

Alvito

2016

WMJ

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Most fungi are able to produce several mycotoxins simultaneously and, consequently, to contaminate a wide variety of foodstuffs. Therefore, the risk of human co-exposure to multiple mycotoxins is real, raising a growing concern about their potential impact on human health. Besides, government and industry regulations are usually based on individual toxicities, and do not take into account the complex dynamics associated with interactions between co-occurring groups of mycotoxins. The present work assembles, for the first time, the challenges posed by the likelihood of human co-exposure to these toxins and the possibility of interactive effects occurring after absorption, towards knowledge generation to support a more accurate human risk assessment. Regarding hazard assessment, a physiologically-based framework is proposed in order to infer the health effects from exposure to multiple mycotoxins in food, including knowledge on the bioaccessibility, toxicokinetics and toxicodynamics of single and combined toxins. The prioritisation of the most relevant mixtures to be tested under experimental conditions that attempt to mimic human exposure and the use of adequate mathematical approaches to evaluate interactions, particularly concerning the combined genotoxicity, were identified as the main challenges for hazard assessment. Regarding exposure assessment, the need of harmonised food consumption data, availability of multianalyte methods for mycotoxin quantification, management of left-censored data, use of probabilistic models and multibiomarker approaches are highlighted, in order to develop a more precise and realistic exposure assessment. To conclude, further studies on hazard and exposure assessment of multiple mycotoxins, using harmonised methodologies, are crucial towards an improvement of data quality and a more reliable and robust risk characterisation, which is central for risk management and, consequently, to prevent mycotoxins-associated adverse effects. A deep understanding of the nature of interactions between multiple mycotoxins will contribute to draw real conclusions on the health impact of human exposure to mycotoxin mixtures.

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Statistical method to assess usual dietary intakes in the European population

Cited by 8 publications

References 11 publications

Aflatoxins in Milk and Dairy Products: Occurrence and Exposure Assessment for the Serbian Population

Aflatoxins in Milk and Dairy Products: Occurrence and Exposure Assessment for the Serbian Population

Exposure assessment of adult consumers in Serbia, Greece and Croatia to deoxynivalenol and zearalenone through consumption of major wheat-based products

Challenges in risk assessment of multiple mycotoxins in food

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