Statistical Methods for Biological Dosimetry

Szłuińska, M.; Edwards, Alan; Lloyd, David

doi:10.1007/978-3-540-71414-9_23

Cited by 12 publications

(10 citation statements)

References 24 publications

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“…In each case, the frequency of dicentrics plus rings in peripheral blood lymphocytes was used to estimate dose. None of the estimated doses were greater than 0.16 Gy, and in most cases doses were on the order of 0.1 Gy or lower, which has been shown to be the limit of detection for the dicentric assay (Szluinska et al 2007). …”

Section: Discussionmentioning

confidence: 97%

The Use of the Dicentric Assay for Biological Dosimetry for Radiation Accidents in Bulgaria

Hadjidekova

Hristova²,

Ainsbury³

et al. 2010

Health Physics

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This paper details the construction of a 137Cs gamma calibration curve that has been established for dicentric assay and the testing and validation of the curve through biological dosimetry in three situations of suspected workplace overexposure that arose accidentally or through negligence or lack of appropriate safety measures. The three situations were: (1) suspected 137Cs contamination in a factory air supply; (2) suspected exposure to an industrial 192Ir source; and (3) accidental exposure of construction workers to radiation from a 60Co radiotherapy source in a hospital medical physics department. From a total of 24 potentially-exposed subjects, only one worker was found to have a statistically significant dose (0.16 Gy, 95% confidence intervals 0.02-0.43 Gy). In all other cases, the main function of the biological dosimetry was to reassure the subjects that any dose received was low.

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Section: Discussionmentioning

confidence: 97%

The Use of the Dicentric Assay for Biological Dosimetry for Radiation Accidents in Bulgaria

Hadjidekova

Hristova²,

Ainsbury³

et al. 2010

Health Physics

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“…If they were not available, it was assumed that the following standard values could be used to calculate the dose uncertainties in the analytical and QB methods: σα = 0.03, σβ = 0.003, σY 0 = 0.0001, σγ = 0.0016. Data were taken from IAEA (2011) (in table marked as IAEA—International Atomic Energy Agency), Szłuińska et al (2005) (HPA—Health Protection Agency), Voisin et al (1997) (NRPB—National Radiation Protection Broad and IRSN—Institut de Radioprotection et de Sûreté Nucléaire, formerly IPSN—Institut de Protection et de Sûreté Nucléaire), and Voisin et al (2004) ( A, B, C —unknown laboratories) …”

Section: Methodsmentioning

confidence: 99%

“…Dose estimation using biodosimetry methods for a mixed neutron and gamma radiation field can be found in the literature (IAEA 2011; Brame and Groer 2003; Szłuińska et al 2005; Fornalski 2014). The most common approaches are the classical iterative method, promoted widely by the International Atomic Energy Agency (IAEA 2011), and the increasingly used Bayesian methods (Brame and Groer 2003; Ainsbury et al 2013a, b; Pacyniak et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Analytical and quasi-Bayesian methods as development of the iterative approach for mixed radiation biodosimetry

Słonecka

Łukasik

Fornalski

2018

Radiat Environ Biophys

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The present paper proposes two methods of calculating components of the dose absorbed by the human body after exposure to a mixed neutron and gamma radiation field. The article presents a novel approach to replace the common iterative method in its analytical form, thus reducing the calculation time. It also shows a possibility of estimating the neutron and gamma doses when their ratio in a mixed beam is not precisely known.

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“…The samples are exposed in uniform radiation field if Chi-square value fits hypothesis value. [ 2 7 8 ] The correlation coefficient r (y, d) was used to find model equation, and recurrent equation was solved to find recurrent coefficients for independent curves, statistical and presenting general calibration dose–effect curve. [ 6 7 8 9 10 ]…”

Section: Methodsmentioning

confidence: 99%

Calibration Curve for Dicentric Chromosomes Induced in Human Blood Lymphocytes Exposed to Gamma Rays at a Dose Rate of 12.5 mGy/s

Que¹,

Duy²,

Luyen³

2016

Genome Integrity

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To develop a calibration curve for induction of dicentric chromosomes by radiation, we have used a 60Co gamma-ray source with dose rate of 12.5 mGy/s. Whole blood from 15 healthy donors was collected. Whole blood from each donor was divided equally into 8 parts for exposing to supposedly physical doses 0, 0.30, 0.50, 1.00, 1.50, 2.00, 3.00 and 4.00 Gy for a independent calibration curve. Whole blood from 15 donors was used to calibrate dose – effect and statistical for general calibration curve. Using Poisson test (U-test) for the distribution of dicentric chromosomes in the metaphases to determine the uniformity of the radiation field. The average from 15 independent calibration curves of linear correlated coefficient was determined to be r (y, d) = 0.5136 ± 0.0038. The model equation derived is y = aD + bD2 + C. The calibration equation of dose-effect was y = 1.01D + 4.43D2 + 0.56.

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Statistical Methods for Biological Dosimetry

Cited by 12 publications

References 24 publications

The Use of the Dicentric Assay for Biological Dosimetry for Radiation Accidents in Bulgaria

The Use of the Dicentric Assay for Biological Dosimetry for Radiation Accidents in Bulgaria

Analytical and quasi-Bayesian methods as development of the iterative approach for mixed radiation biodosimetry

Calibration Curve for Dicentric Chromosomes Induced in Human Blood Lymphocytes Exposed to Gamma Rays at a Dose Rate of 12.5 mGy/s

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