Statistical shape modeling of the hip and the association with hip osteoarthritis: a systematic review

Buuren, M.M.A. van; Arden, N K; Bierma-Zeinstra, Sita M A; Bramer, Wichor M.; Casartelli, Nicola C.; Felson, David T.; Jones, Graeme; Lane, Nancy E.; Lindner, Claudia; Maffiuletti, Nicola A.; Meurs, J.B. van; Nelson, Amanda; Nevitt, Michael C.; Verhaar, Jan A N; Weinans, Harrie; Agricola, Rintje

doi:10.1016/j.joca.2020.12.003

Cited by 37 publications

(22 citation statements)

References 45 publications

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“…Higher α angle increased the risk of radiographic hip OA in woman over 20 years 6 . A systematic review established that several radiographic features detected by SSM were associated with incidence or progression of OA 34 . However, these studies do not describe associations of cam morphology in the left and/or right hip.…”

Section: Discussionmentioning

confidence: 99%

“…Previous literature demonstrates that shape variations of the femoral head predict THR, 1,14,42 and in the last few years this concept has been well established 34,42‐45 . Each study has used different methods to assess cam morphology, but the results are more or less similar.…”

Section: Discussionmentioning

confidence: 99%

“…Previous literature demonstrates that shape variations of the femoral head predict THR, 1,14,42 and in the last few years this concept has been well established. 34,[42][43][44][45] Each study has used different methods to assess cam morphology, but the results are more or less similar. For example, in the CHECK study, the presence of cam-type deformity (α angle >60°) predicted 3 times higher risk of hip OA, while severe cam-type deformity (α angle >83°) predicted 10 times higher risk of hip OA.…”

Section: Cam Morphology and Thrmentioning

confidence: 99%

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A prospective cohort study on cam morphology and its role in progression of osteoarthritis

et al. 2022

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Background: Cam morphology contributes to the development of hip osteoarthritis (OA) but is less studied in the general population. This study describes its associations with clinical and imaging features of hip OA. Methods:Anteroposterior hip radiographs of 1019 participants from the Tasmanian Older Adult Cohort (TASOAC) were scored at baseline for α angle (cam morphology) in both hips. Using the Altman's atlas, radiographic hip OA (ROA) was assessed at baseline. Hip pain and right hip structural changes were assessed on a subset of 245 magnetic resonance images (MRI) at 5 years. Joint registry data for total hip replacement (THR) was acquired 14 years from baseline.Results: Of 1906 images, cam morphology was assessed in 1016 right and 890 left hips. Cross-sectionally, cam morphology modestly associated with age (prevalence ratio [PR]: 1.02 P = .03) and body mass index (BMI) (PR: 1.03-1.07, P = .03) and strongly related to male gender (PR: 2.96, P < .001). Radiographically, cam morphology was prevalent in those with decreased joint space (PR: 1.30 P = .03) and osteophytes (PR:1.47, P = .03). Longitudinally, participants with right cam and high BMI had more hip pain (PR: 17.9, P = .02). At the end of 5 years of follow-up these participants were also more likely to have structural changes such as bone marrow lesions (BMLs) (PR: 1.90 P = .04), cartilage defects (PR: 1.26, P = .04) and effusion-synovitis at multiple sites (PR: 1.25 P = .02). Cam morphology at baseline in either hip predicted up to threefold risk of THR (PR: 3.19, P = .003) at the end of 14 years. Conclusion:At baseline, cam morphology was linked with age, higher weight, male gender, early signs of radiographic OA such as joint space narrowing (JSN) and osteophytes (OST). At follow-up, cam predicted development of hip BMLs, hip effusionsynovitis, cartilage damage and THR. These findings suggest that cam morphology plays a significant role in early OA and can be a precursor or contribute to hip OA in later life.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Cam Morphology and Thrmentioning

confidence: 99%

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A prospective cohort study on cam morphology and its role in progression of osteoarthritis

et al. 2022

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“…9,10 Other risk factors for hip OA development include altered joint shape, high-impact sports, occupational loading, and genetic predisposition. 7,8,[11][12][13] Female sex, older age, overweight/obesity, occupational loading, local muscle weakness, and genetic predisposition are all known to increase the risk for incident hand OA. 8,[14][15][16] A very important point to consider here is the fact that most studies on risk factors for OA development have focused on the development of OA disease, that is, pathologic changes in joint tissues.…”

Section: Identifying the Target Group Risk Factors For Osteoarthritis...mentioning

confidence: 99%

“…1): prevention and treatment of risk factors for OA development at those stages of life where these risk factors are developing or amendable to treatment. 17 Looking Beyond the Single-Risk Factors Approach Despite the fact that there are multiple known strong risk factors for OA development, 6,7,11,14 it is the actual combination of the prevalence of the risk factor and the…”

Section: Identification Of Individuals With Osteoarthritis Risk Factorsmentioning

confidence: 99%

The Challenges in the Primary Prevention of Osteoarthritis

Runhaar

Bierma-Zeinstra

2022

Clinics in Geriatric Medicine

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Associations Between Baseline and Longitudinal Semiautomated Quantitative Joint Space Width at the Hip and Incident Hip Osteoarthritis: Data From a Community‐Based Cohort

Nelson

Smith

Álvarez

et al. 2022

Arthritis Care & Research

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Objective. To evaluate quantitative joint space width (JSW) at 10-, 30-, and 50-degree locations in relation to incident radiographic and symptomatic hip osteoarthritis (HOA) in a community-based cohort.Methods. Data were from Johnston County OA Project participants with supine hip radiographs at each of 4 time points; all had Kellgren/Lawrence (K/L) grades and quantitative JSW. We assessed covariates (age, race, height, weight, body mass index [BMI]) associated with quantitative JSW and hip-level associations between quantitative JSW and HOA over time using sex-stratified and multivariable-adjusted linear mixed models. A cluster analysis with logistic regression estimated associations between quantitative JSW trajectory groups and incident radiographic HOA and symptomatic HOA.Results. At baseline, 397 participants (784 hips, 41% men, 24% Black, mean age 57 years) had a mean BMI of 29 kg/m 2 . Over a mean of 18 years, 20% and 12% developed incident K/L grade-defined radiographic HOA or symptomatic HOA, respectively. Quantitative JSW was more sensitive to changes over time at 50 degrees. Values were stable among men but declined over time in women. Heavier women lost more quantitative JSW; changes in quantitative JSW were not significantly associated with race, education, or injury in women or men. In women only, loss of quantitative JSW over time was associated with 2-3 times higher odds of radiographic HOA and symptomatic HOA; among women and men, narrower baseline quantitative JSW was associated with these outcomes.Conclusion. Hip quantitative JSW demonstrates marked differences in respect to sex, with significant loss over time only in women. Loss of quantitative JSW over time in women and narrower baseline quantitative JSW in men and women were associated with incident radiographic HOA and symptomatic HOA.

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Statistical shape modeling of the hip and the association with hip osteoarthritis: a systematic review

Cited by 37 publications

References 45 publications

A prospective cohort study on cam morphology and its role in progression of osteoarthritis

A prospective cohort study on cam morphology and its role in progression of osteoarthritis

The Challenges in the Primary Prevention of Osteoarthritis

Associations Between Baseline and Longitudinal Semiautomated Quantitative Joint Space Width at the Hip and Incident Hip Osteoarthritis: Data From a Community‐Based Cohort

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