Statistical study on melanoma in Japan (1961-1970)

Seiji, Makoto; Ohsumi, Takeshi

doi:10.1097/00006534-197401000-00065

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“…Although the histogenesis of malignant melanoma still remains a controversial subject, the incidence of intraepi thelial malignant melanoma among all melanomas in Melanocyte Distribution in the Lower Lip of the Elderly Japan is known to be substantially higher than in Western countries [11,12]. In addition, it is also well known that malignant melanoma of the oral cavity has a more serious prognosis than does cutaneous melanoma [ 13].…”

Section: Discussionmentioning

confidence: 99%

Immunopathological Analysis of Mucosal Melanocyte Distribution in the Human Lower Lip of the Elderly

et al. 1996

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Mucosal melanocyte distribution in the human lower lip was analyzed immunopathologically using a wide selection of 195 surgical specimens. An age-related increase of mucosal melanocyte distribution was observed in the human lower lip by Fontana-Masson argentaffin stain and S-100 protein immunoreactivity. The mean number of mucosal melanocytes increased gradually with advancing age. A large number of them was found at or beyond the seventh decade of life in both sexes, which was statistically significant compared with those in all other decades (p < 0.01 or < 0.05). In addition, the sex difference in mucosal melanocyte density was statistically significant (p < 0.001) in each decade (men > women). These results suggest that physiological changes in mucosal melanocyte distribution are dependent upon aging and sex difference, and may play an important role in development of melanocytic lesions such as senile lentigo, pigmented nevi, and also intraepithelial malignant melanomas.

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Section: Discussionmentioning

confidence: 99%