2022
DOI: 10.21608/aprh.2022.158576.1189
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Statistically-Based Optimization of Verapamil Hydrochloride Loaded Gastroretentive Alginate Beads

Abstract: Objectives: A gastroretentive drug delivery system is one of many oral drug delivery systems developed to improve drug bioavailability and control drug release. It allows prolongation of drug gastric residence period for several hours. Verapamil Hydrochloride (VerHCl) is a good candidate for gastro retention because it has narrow absorption window and short half life. The goal of this study was formulation and evaluation of optimized VerHCl loaded gastroretentive alginate beads for increasing drug bioavailabil… Show more

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