Status and future perspectives of vaccines for industrialised fin-fish farming

Brudeseth, Bjørn; Wiulsrød, Rune; Fredriksen, Børge Nilsen; Lindmo, Karine; Løkling, Knut-Egil; Bordevik, Marianne; Steine, Nils; Klevan, Are; Gravningen, Kjersti

doi:10.1016/j.fsi.2013.05.029

Cited by 239 publications

(145 citation statements)

References 65 publications

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“…Ideally, cost-effective mass vaccination of young fish is performed by immersion vaccination, meaning that the fish are bathed in water containing the vaccine. This procedure allows vaccination of a large number of subjects when their individual value is still low and their susceptibility to the disease is the highest (Brudeseth et al, 2013). Immersion vaccination is particularly adapted to common carp culture that is a low-cost and low industrial scale production compared to other sectors (Brudeseth et al, 2013).…”

Section: Vaccine Candidatesmentioning

confidence: 99%

Cyprinid Herpesvirus 3

Boutier

Ronsmans

Rakus

et al. 2015

Advances in Virus Research

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Section: Vaccine Candidatesmentioning

confidence: 99%

Cyprinid Herpesvirus 3

Boutier

Ronsmans

Rakus

et al. 2015

Advances in Virus Research

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“…Although antibiotics have been widely used for disease treatment, mainly in fries and fingerlings (Brudeseth et al 2013), the surge of antibiotics-resistant bacteria, and antibiotics residues in water and meat, raised major concerns towards this management procedure. In this scenario, strengthening the fish defense mechanisms by vaccination to specific pathogens or by adding immune modulating molecules in the diet has been increasingly explored as an economically viable procedure to prevent disease outbreaks (Bricknell & Dalmo 2005, Sommerset et al 2005, Plant & Laptra 2011, Bairwa et al 2012.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory effects of dietary β-glucan in silver catfish (Rhamdia quelen)

Domenico

Canova²,

Soveral³

et al. 2017

Pesq. Vet. Bras.

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RESUMO.-[Efeito imunomodulador da β-glucana usada como aditivo alimentar em jundiás (Rhamdia quelen).]O uso da β-glucana como suplemento alimentar foi avaliado em jundiás. A β-glucana foi adicionada à ração na proporção de 0.01%, e 0.1% e fornecida aos peixes por 21, para avaliar dados hematológicos e parâmetros do sistema imune natural, ou 42 dias, para avaliar ganho de peso e resistência ao desafio com Aeromonas hydrophila. A adição da β-glucana na dieta não afetou o ganho de peso e não induziu alterações hematológicas nem alterações nos níveis de aglutininas e mieloperoxidase sanguínea. No entanto, a atividade hemolítica natural do sistema do complemento foi significativamente maior nos peixes alimentados com β-glucana. Além disso, nos peixes alimentados com β-glucana e desafiados com A. hydrophila, o número de bactérias isoladas do sangue foi significativamente menor, e a sobrevivência ao desafio foi significativamente maior do que nos peixes que não receberam β-glucana. Consequentemente, concluímos que a β-glucana tem potencial imunomodulador quando adicionada à dieta, nas condições experimentais aqui indicadas, e contribui para aumentar imunidade natural e a resistência dos jundiás ao desafio com patógenos específicos. INTRODUCTIONThe occurrence of infectious diseases is one of the major causes of losses in modern aquaculture (Sitjà-Bobadilla The immunomodulatory effects of dietary β-glucan were evaluated in silver catfish. β-glucan was added to the diet (0.01%, and 0.1%) and fed to the fish for 21 days, to evaluate effects on blood and some innate immune parameter, or fed for 42 days, to evaluate growth rate and resistance to challenge with pathogenic Aeromonas hydrophila. We found that adding β-glucan to the diet had no effect on fish growth and no effect on blood cells, or serum bacterial agglutination and serum myeloperoxidase activity. However, fish that received β-glucan in the diet had the natural hemolytic activity of complement significantly higher compared to control fish. Furthermore, fish fed with β-glucan and challenged with A. hydrophila had fewer bacteria in blood and presented a significantly higher survival rate compared to control fish. Thus, we concluded that β-glucan might be explored as feed additive aiming to improve silver catfish innate immunity and resistance to specific pathogen.INDEX TERMS: Silver catfish, Rhamdia quelen, fish, immunostimulants, β-glucan, Aeromonas hydrophila.

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“…The majority of the coho salmon to enter the market are harvested commercially (wild-caught) throughout the Pacific (FAO 2015). While North American (farmed) production has significantly declined over the years, coho salmon is considered one of the high-value industrialized salmonid species in global aquaculture, along with Atlantic salmon and rainbow trout (Brudeseth et al 2013). In addition to its importance in the marketplace, coho salmon provides a conservation and evolutionary model for study among the salmonids.…”

Section: Introductionmentioning

confidence: 99%

Food Shortage Causes Differential Effects on Body Composition and Tissue-Specific Gene Expression in Salmon Modified for Increased Growth Hormone Production

Abernathy¹,

Panserat²,

Welker³

et al. 2015

Mar Biotechnol

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Growth hormone (GH) transgenic salmon possesses markedly increased metabolic rate, appetite, and feed conversion efficiency, as well as an increased ability to compete for food resources. Thus, the ability of GH-transgenic fish to withstand periods of food deprivation as occurs in nature is potentially different than that of nontransgenic fish. However, the physiological and genetic effects of transgenic GH production over long periods of food deprivation remain largely unknown. Here, GH-transgenic coho salmon (Oncorhynchus kisutch) and nontransgenic, wild-type coho salmon were subjected to a 3-month food deprivation trial, during which time performance characteristics related to growth were measured along with proximate compositions. To examine potential genetic effects of GH-transgenesis on long-term food deprivation, a group of genes related to muscle development and liver metabolism was selected for quantitative PCR analysis. Results showed that GH-transgenic fish lose weight at an increased rate compared to wild-type even though proximate compositions remained relatively similar between the groups. A total of nine genes related to muscle physiology (cathepsin, cee, insulin-like growth factor, myostatin, murf-1, myosin, myogenin, proteasome delta, tumor necrosis factor) and five genes related to liver metabolism (carnitine palmitoyltransferase, fatty acid synthase, glucose-6-phosphatase, glucose-6-phosphate dehydrogenase, glucokinase) were shown to be differentially regulated between GH-transgenic and wild-type coho salmon over time. These genetic and physiological responses assist in identifying differences between GH-transgenic and wild-type salmon in relation to fitness effects arising from elevated growth hormone during periods of long-term food shortage.

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Status and future perspectives of vaccines for industrialised fin-fish farming

Cited by 239 publications

References 65 publications

Cyprinid Herpesvirus 3

Cyprinid Herpesvirus 3

Immunomodulatory effects of dietary β-glucan in silver catfish (Rhamdia quelen)

Food Shortage Causes Differential Effects on Body Composition and Tissue-Specific Gene Expression in Salmon Modified for Increased Growth Hormone Production

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