Status epilepticus in children: Causes, clinical features and short‐term outcome

Besli, Gülser Esen; Saltık, Sema; Ergüven, Müferet; Bulut, Özgül; Abul, Mehtap Haktanır

doi:10.1111/j.1442-200x.2010.03164.x

Cited by 17 publications

(20 citation statements)

References 13 publications

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“…Our results are in coherence with other studies from India and outside which have shown GTCS as the most common type of seizure. [ 15 20 25 26 ] Although the majority of patients with SE have GTCSs, some studies indicate that partial seizures also represent a major type of SE in children which is contradictory to our results. Besli et al .…”

Section: Discussioncontrasting

confidence: 99%

“…[ 9 15 ] Studies outside India have also found male predominance for SE in children. [ 2 20 21 ] However, to the best of our knowledge, no definite causal relationship was found in literature for this male preponderance and warrants further investigation in future studies. However, there have been few studies which have found female preponderance for SE in children.…”

Section: Discussionmentioning

confidence: 73%

“…Besli et al . [ 20 ] in their study found 27% of SE as partial seizure type and 22% as secondarily generalized type. DeLorenzo et al .…”

Section: Discussionmentioning

confidence: 97%

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Sociodemographic Profile, Semiology, and Etiology of Patients with Status Epilepticus: A Study from a Tertiary Care Hospital in North India

Qadir

Wani

Bhat

2018

Journal of Neurosciences in Rural Practice

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Background and Objectives:Despite advance in treatment of status epilepticus (SE), a major neurological emergency, it is still associated with mortality and morbidity. The objective of our study was to estimate sociodemographic profile, semiology, and etiology in the children with SE admitted in pediatric intensive care.Materials and Methods:Children between 1 month and 18 years with continuous seizure activity of >5 min or two or more sequential seizures without full recovery of consciousness between seizures, admitted in the Pediatric Intensive Care Unit of the Department of Pediatrics, Government Medical College, Srinagar, were included in the study. A semi-structured tool was designed to record the sociodemographic details. Detailed history, clinical examination, and investigations (including neuroimaging as and when needed) were used to determine the type of seizure and etiology.Results:A total of 51 patients were included in our study. Most of the patients were <5 years with 47.10% in 1–5 years’ age group and 43.10% in >1-year age group. Males (60.80%) outnumbered females. Thirty-nine patients (76.47%) belonged to “known” or “symptomatic” group with 35 (68.60%) of them presenting with SE as their fresh seizure. Thirty-nine (76.47%) of our patients had generalized tonic–clonic seizure (GTCS) type of SE.Conclusion:Most of the children (90%) were below the age of 5 years with male predominance. Most of the patients had SE as their first seizure without prior history of seizures with GTCSs was the most frequent seizure type.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 73%

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Sociodemographic Profile, Semiology, and Etiology of Patients with Status Epilepticus: A Study from a Tertiary Care Hospital in North India

Qadir

Wani

Bhat

2018

Journal of Neurosciences in Rural Practice

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“…7,25 As seizure duration lengthens, spontaneous resolution becomes more difficult, and this may particularly be true of febrile seizures. 7,13,26,27 Delays in treatment of FSE have been observed in previous studies. 10,16,26 A review of the Virginia Commonwealth University SE database, which includes all SE and both pediatrics and adults, found that less than half of SE patients received their first dose of an AED within 30 min of seizure onset.…”

Section: Discussionsupporting

confidence: 52%

Emergency management of febrile status epilepticus: Results of the FEBSTAT study

et al. 2014

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Objective Treatment of seizures varies by region with no standard emergency treatment protocol. Febrile status epilepticus (FSE) is often a child’s first seizure; therefore, families are rarely educated about emergency treatment. Methods From 2002 to 2010, 199 subjects, age 1 month to 6 years, were recruited as part of a prospective, multicenter study of consequences of FSE. FSE was defined as a febrile seizure or series of seizures lasting >30 minutes. The patients’ charts were reviewed. No standardized treatment protocol was implemented for this observational study. Results 179 received at least one antiepileptic drug (AED) to terminate FSE and more than one AED was required in 140 patients (70%). Median time from the seizure onset to first AED by EMS or ED was 30 minutes. Mean seizure duration was 81 minutes for subjects given medication prior to ED and 95 minutes for those who did not (p=0.1). Median time from the first dose of AED to end of seizure was 38 minutes. Initial dose of lorazepam or diazepam was suboptimal in 32 of 166 patients (19%). Ninety-five (48%) subjects received respiratory support by EMS or ED. Median seizure duration for respiratory support group was 83 minutes; for non-respiratory support group was 58 minutes (p-value < 0.001). Reducing the time from seizure onset to AED initiation was significantly related to shorter seizure duration. Significance FSE rarely stops spontaneously, is fairly resistant to medications and even with treatment persists for a significant period of time. The total seizure duration is composed of two separate factors; the time from seizure onset to AED initiation, and the time from first AED to seizure termination. Earlier onset of treatment results in shorter total seizure duration. A standard pre-hospital treatment protocol should be used nationwide and education of EMS responders is necessary.

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“…5 The incidence is more common in male children 33(63%).Similar male preponderance is seen in a study done by Besli and Saltik. 6 The cause of convulsive status epilepticus varies across age groups. Shinnar et al in their study has shown that febrile status epilepticus and acute symptomatic etiologies are more common in children less than 2 years whereas remote symptomatic and idiopathic etiologies are common in older children.…”

Section: Discussionmentioning

confidence: 99%

Convulsive status epilepticus in children

Jagannathan¹,

Palanivelu²

2017

Int J Contemp Pediatr

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Background: Present study was undertaken to study the clinical profile, immediate outcome and possible risk factors for mortality in children with convulsive status epilepticus, admitted in pediatric intensive care unit in a tertiary care centre.Methods: This retrospective descriptive study included children between 1 month and 12 years of age admitted in pediatric intensive care unit with convulsive status epilepticus from April 2016 to March 2017. They were evaluated for their clinical presentation, laboratory parameters and immediate outcome. Data were gathered on 52 patients with convulsive status epilepticus. Factors were analysed using univariate and multivariate analyses.Results: Among the 52 patients, the observations made were, common age group1-5years (51%), males (63%), wih fever (62%), idiopathic seizures (41.5%), febrile status epilepticus (22.7%) abnormal eeg (9.4%), leuocytosis (54.7%), csf abnormalities (33%), prolonged seizures (33%), need for intubation (31%), shock (29%), mortality (9.4%).Conclusions: Clinical profile of children with convulsive status epilepticus is described. Presence of shock, need for intubation and prolonged seizures are significantly associated with mortality.

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Status epilepticus in children: Causes, clinical features and short‐term outcome

Cited by 17 publications

References 13 publications

Sociodemographic Profile, Semiology, and Etiology of Patients with Status Epilepticus: A Study from a Tertiary Care Hospital in North India

Sociodemographic Profile, Semiology, and Etiology of Patients with Status Epilepticus: A Study from a Tertiary Care Hospital in North India

Emergency management of febrile status epilepticus: Results of the FEBSTAT study

Convulsive status epilepticus in children

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