STAU1 selectively regulates the expression of inflammatory and immune response genes and alternative splicing of the nerve growth factor receptor signaling pathway

Zhong, Yi; Hu, Zhengchao; Wu, Jingcui; Lee, Feng; Xu, Yan

doi:10.3892/or.2020.7769

Cited by 11 publications

(17 citation statements)

References 92 publications

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“…Furthermore, a recent study provided evidence on the critical role of STAU1 in neural cell survival and growth through regulation of alternative splicing and expression of genes (e.g., PDGFB, C–C motif chemokine ligand 2 or CCL2, OASL) its involvement in the nerve growth factor signaling pathway. Therefore, STAU1 expression appears critical for the proper splicing and expression of neural genes [ 69 ].…”

Section: Role Of Stau1 In the Regulation Of Cell Functions And Its Associated Impact On Cancermentioning

confidence: 99%

“…Similarly, we reported that STAU1 overexpression in C2C12 prevents myogenic differentiation by reducing the expression of MyoD, myogenin, MEF2A, and MEF2C via SMD-independent mechanisms [ 66 ]. Moreover, GO enrichment and KEGG pathway analysis revealed that STAU1 regulates alternative mRNA splicing of genes involved in muscle cell differentiation [ 69 ].…”

Section: Role Of Stau1 In the Regulation Of Cell Functions And Its Associated Impact On Cancermentioning

confidence: 99%

“…These findings reveal the positive role of STAU1 in the differentiation of neuroblastoma cells that may further impact the stage of the disease. Moreover, in Hela and Neuro-2a cell lines, STAU1 has been shown to regulate alternative splicing of genes involved in neural growth and differentiation such as PLEKHG2 and ARHGEF1 [ 69 ]. Thus, proper regulation of STAU1-mediated alternative splicing in these cells is crucial for normal neural growth, proliferation, and axon development [ 69 ].…”

Section: Role Of Stau1 In the Regulation Of Cell Functions And Its Associated Impact On Cancermentioning

confidence: 99%

“…Importantly, mis-migrating PGCs failed to survive in the STAU1-compromised embryo, highlighting the significance of STAU1 in germline and embryo development by regulating cell migration [ 22 ]. More recently, STAU1 has been reported to regulate alternative splicing and expression level of CCL2 mRNAs whose protein product is responsible for leukocyte migration and inflammatory response [ 69 ]. Since cell migration is a critical step in tumor progression [ 89 ], several studies uncovered role of STAU1 in the regulation of cell migration during cancer development and tumorigenesis.…”

Section: Role Of Stau1 In the Regulation Of Cell Functions And Its Associated Impact On Cancermentioning

confidence: 99%

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The multifunctional RNA-binding protein Staufen1: an emerging regulator of oncogenesis through its various roles in key cellular events

Almasi

Jasmin

2021

Cell. Mol. Life Sci.

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The double-stranded multifunctional RNA-binding protein (dsRBP) Staufen was initially discovered in insects as a regulator of mRNA localization. Later, its mammalian orthologs have been described in different organisms, including humans. Two human orthologues of Staufen, named Staufen1 (STAU1) and Staufen2 (STAU2), share some structural and functional similarities. However, given their different spatio-temporal expression patterns, each of these orthologues plays distinct roles in cells. In the current review, we focus on the role of STAU1 in cell functions and cancer development. Since its discovery, STAU1 has mostly been studied for its involvement in various aspects of RNA metabolism. Given the pivotal role of RNA metabolism within cells, recent studies have explored the mechanistic impact of STAU1 in a wide variety of cell functions ranging from cell growth to cell death, as well as in various disease states. In particular, there has been increasing attention on the role of STAU1 in neuromuscular disorders, neurodegeneration, and cancer. Here, we provide an overview of the current knowledge on the role of STAU1 in RNA metabolism and cell functions. We also highlight the link between STAU1-mediated control of cellular functions and cancer development, progression, and treatment. Hence, our review emphasizes the potential of STAU1 as a novel biomarker and therapeutic target for cancer diagnosis and treatment, respectively.

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Section: Role Of Stau1 In the Regulation Of Cell Functions And Its Associated Impact On Cancermentioning

confidence: 99%

Section: Role Of Stau1 In the Regulation Of Cell Functions And Its Associated Impact On Cancermentioning

confidence: 99%

Section: Role Of Stau1 In the Regulation Of Cell Functions And Its Associated Impact On Cancermentioning

confidence: 99%

Section: Role Of Stau1 In the Regulation Of Cell Functions And Its Associated Impact On Cancermentioning

confidence: 99%

See 2 more Smart Citations

The multifunctional RNA-binding protein Staufen1: an emerging regulator of oncogenesis through its various roles in key cellular events

Almasi

Jasmin

2021

Cell. Mol. Life Sci.

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show abstract

“…Both Staufen-1 and Staufen-2 contain four double-stranded RNA-binding domains (dsRBD) and bind to distinct but overlapping sets of mRNAs [18,19]. Although several studies define multiple roles of Staufens in neural cells [20][21][22][23], these proteins are also expressed across different cell types, including T cells and macrophages, and are involved in different functions, such as cellcycle regulation, apoptosis, organogenesis, and regulation of inflammatory and immune response genes expression [18,[24][25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Encapsidation of Staufen-2 Enhances Infectivity of HIV-1

Balakrishnan

Vasudevan

Mohareer

et al. 2021

Viruses

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Staufen, the RNA-binding family of proteins, affects various steps in the Human Immuno-Deficiency Virus (HIV-1) replication cycle. While our previous study established Staufen-2–HIV-1 Rev interaction and its role in augmenting nucleocytoplasmic export of RRE-containing viral RNA, viral incorporation of Staufen-2 and its effect on viral propagation were unknown. Here, we report that Staufen-2 interacts with HIV-1 Gag and is incorporated into virions and that encapsidated Staufen-2 boosted viral infectivity. Further, Staufen-2 gets co-packaged into virions, possibly by interacting with host factors Staufen-1 or antiviral protein APOBEC3G, which resulted in different outcomes on the infectivity of Staufen-2-encapsidated virions. These observations suggest that encapsidated host factors influence viral population dynamics and infectivity. With the explicit identification of the incorporation of Staufen proteins into HIV-1 and other retroviruses, such as Simian Immunodeficiency Virus (SIV), we propose that packaging of RNA binding proteins, such as Staufen, in budding virions of retroviruses is probably a general phenomenon that can drive or impact the viral population dynamics, infectivity, and evolution.

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RNA-Binding Proteins: A Role in Neurotoxicity?

Ocharán-Mercado,

Loaeza-Loaeza,

Castro-Coronel

et al. 2023

Neurotox Res

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Despite sustained efforts to treat neurodegenerative diseases, little is known at the molecular level to understand and generate novel therapeutic approaches for these malignancies. Therefore, it is not surprising that neurogenerative diseases are among the leading causes of death in the aged population. Neurons require sophisticated cellular mechanisms to maintain proper protein homeostasis. These cells are generally sensitive to loss of gene expression control at the post-transcriptional level. Post-translational control responds to signals that can arise from intracellular processes or environmental factors that can be regulated through RNA-binding proteins. These proteins recognize RNA through one or more RNA-binding domains and form ribonucleoproteins that are critically involved in the regulation of post-transcriptional processes from splicing to the regulation of association of the translation machinery allowing a relatively rapid and precise modulation of the transcriptome. Neurotoxicity is the result of the biological, chemical, or physical interaction of agents with an adverse effect on the structure and function of the central nervous system. The disruption of the proper levels or function of RBPs in neurons and glial cells triggers neurotoxic events that are linked to neurodegenerative diseases such as spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS), fragile X syndrome (FXS), and frontotemporal dementia (FTD) among many others. The connection between RBPs and neurodegenerative diseases opens a new landscape for potentially novel therapeutic targets for the intervention of these neurodegenerative pathologies. In this contribution, a summary of the recent findings of the molecular mechanisms involved in the plausible role of RBPs in RNA processing in neurodegenerative disease is discussed.

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STAU1 selectively regulates the expression of inflammatory and immune response genes and alternative splicing of the nerve growth factor receptor signaling pathway

Cited by 11 publications

References 92 publications

The multifunctional RNA-binding protein Staufen1: an emerging regulator of oncogenesis through its various roles in key cellular events

The multifunctional RNA-binding protein Staufen1: an emerging regulator of oncogenesis through its various roles in key cellular events

Encapsidation of Staufen-2 Enhances Infectivity of HIV-1

RNA-Binding Proteins: A Role in Neurotoxicity?

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