Stem Cell and Biomaterials Research in Dental Tissue Engineering and Regeneration

Horst, Orapin V.; Chavez, Miquella G.; Jheon, Andrew H.; Desai, Tejal A.; Klein, Ophir D.

doi:10.1016/j.cden.2012.05.009

Cited by 66 publications

(57 citation statements)

References 207 publications

(193 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…9 Platelet rich fibrin (PRF) is a natural biomaterial that can produce easily from autologous blood that was centrifuged without anticoagulant, forming fibrin matrix which polymerized naturally and slowly. PRF is rich in growth factors such as PDGF-β, TGFβ-1, VEGF, IGF-I, leukocyte; cytokine such as IL-1β, IL-6, IL-4, and TNFα; and circulating stem cell.…”

Section: 4mentioning

confidence: 99%

Chondrogenic Differentiation Capacity of Human Umbilical Cord Mesenchymal Stem Cells with Platelet Rich Fibrin Scaffold in Cartilage Regeneration (In Vitro Study)

Sumarta

Hendrianto

et al. 2016

Bali Med J.

View full text Add to dashboard Cite

Background: Human umbilical cord mesenchymal stem cell is a promising source of allogenous MSC with great chondrogenic differentiation capacity. Meanwhile, platelet rich fibrin (PRF) is a natural fibrin matrix, rich in growth factors, forming a smooth and flexible fibrin network, supporting cytokines and cell migration, thus can be used as a scaffold that facilitate the differentiation of MSC. However, the differential capability of MSC cultured in PRF was still poorly understood. Method:We studied in vitro differentiation potential of MSC cultured in PRF by evaluating several markers such as FGF 18, Sox 9, type II collagen, aggrecan in 3 different culture medium. Result: The result showed that there was positive expression of FGF 18, Sox 9, type II collagen, aggrecan in all medium of in vitro culture. Conclusion: MSC cultured from human umbilical cord had the capacity of chondrogenic differentiation and able to produce cartilage extracellular matrix in vitro which means that hUCMSC is a potential allogeneic MSC for cartilage regeneration.

show abstract

Section: 4mentioning

confidence: 99%

Chondrogenic Differentiation Capacity of Human Umbilical Cord Mesenchymal Stem Cells with Platelet Rich Fibrin Scaffold in Cartilage Regeneration (In Vitro Study)

Sumarta

Hendrianto

et al. 2016

Bali Med J.

View full text Add to dashboard Cite

show abstract

“…[57] PCL:-Is a slowly degrading polymer that have been used toward tissue engineering efforts in bone, either aloneor combined with hydroxyapatite. [58] Poly-lactic-co-glycolic acid:-Is the first copolymer mixture to gain approval from Food and Drug Administration. PLGA has been used in engineering bone, liver and cartilage.…”

Section: Issn: 2320-5407mentioning

confidence: 99%

“…PLGA has been used in engineering bone, liver and cartilage. [59] Bertoldi tested a 50:50 PLGA copolymer and stated that it is free of inflammation effects, seems to stimulate bone growth, and decomposes after 6-8 months. [60] They also showed a strong alkaline phosphatase expression, indicating a probable promotion effect on bone cells.…”

Section: Issn: 2320-5407mentioning

confidence: 99%

Scaffolds in Regenerative Endodontics: A Review.

Ch¹,

Suvarna²,

Shetty³

et al. 2017

IJAR

View full text Add to dashboard Cite

“…(8) The extracted stem cells are grown on an appropriate scaffold made of biomaterials (like polyglycolic acid, polytetrafluoroethylene), fibrin sealant and certain growth factors, which act as temporary matrix during the regeneration of tissue. (9,10) Application in Orofacial Region: Mesenchymal stem cells derived from dental and nondental sources have been effectively used for regeneration in maxillofacial region like regeneration of tooth, pulp, periodontal ligament, production of enamel and dentin, regeneration of salivary gland, repair of cleft lip and palate and craniofacial regeneration. (11,12,13) However, the use of stem cell treatment for oral mucosal lesions is a new concept, which needs to be reviewed to promote the research further in the area.…”

Section: Introduction: Basic Concepts Of Stem Cellsmentioning

confidence: 99%

LITERATURE REVIEW ON STEM CELL TREATMENT & ORAL SUBMUCOUS FIBROSIS (OSMF)

Sudhakar¹,

Kameswararao²

2015

jemds

View full text Add to dashboard Cite

Stem cell therapy is a part of regenerative medicine that involves the use of undifferentiated cells in order to cure the disease. Stem cell-based therapies are being investigated for the treatment of many conditions, including neurodegenerative conditions such as Parkinson's disease, cardiovascular disease, liver disease, diabetes, autoimmune diseases and for nerve regeneration. (1) In orofacial region these therapies are being used for tooth and periodontal regeneration, temporomandibular joint reconstruction, alveolar bone regeneration. Craniofacial stem cells including dental pulp derived stem cells have the potential to cure a number of diseases.Present day treatment modalities for oral mucosal lesions like ulcerative lesions, premalignancies and malignancies mainly consist of steroids and antioxidants (which provide only a short term and symptomatic relief) and surgery with or without chemo/radiotherapy (which leave the patient with certain amount of morbidity). Advances in stem cell technology have opened new vistas for treatment of these lesions. Various studies have shown the successful role of stem cell therapies in the treatment of precancerous conditions, oral ulcers, wounds and mucositis. (2) The recent concept of cancer stem cells (CSCs) has directed scientific communities toward a new area of research and possible potential treatment modalities for oral cancer. (3) The present article will discuss the role of stem cell applications in oral mucosal lesions.

show abstract

Stem Cell and Biomaterials Research in Dental Tissue Engineering and Regeneration

Cited by 66 publications

References 207 publications

Chondrogenic Differentiation Capacity of Human Umbilical Cord Mesenchymal Stem Cells with Platelet Rich Fibrin Scaffold in Cartilage Regeneration (In Vitro Study)

Chondrogenic Differentiation Capacity of Human Umbilical Cord Mesenchymal Stem Cells with Platelet Rich Fibrin Scaffold in Cartilage Regeneration (In Vitro Study)

Scaffolds in Regenerative Endodontics: A Review.

LITERATURE REVIEW ON STEM CELL TREATMENT & ORAL SUBMUCOUS FIBROSIS (OSMF)

Contact Info

Product

Resources

About