Stem Cell-Based Embryo Models: En Route to a Programmable Future

Chen, Yunping; Shao, Yue

doi:10.1016/j.jmb.2021.167353

Journal of Molecular Biology

2022

DOI: 10.1016/j.jmb.2021.167353

|View full text |Cite

Stem Cell-Based Embryo Models: En Route to a Programmable Future

Yunping Chen

Yue Shao

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2022

2024

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 5 publications

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

The Ethics of Stem Cell-Based Embryo-Like Structures

Pereira Daoud,

Dondorp,

Bredenoord

et al. 2024

Bioethical Inquiry

View full text Add to dashboard Cite

In order to study early human development while avoiding the burdens associated with human embryo research, scientists are redirecting their efforts towards so-called human embryo-like structures (hELS). hELS are created from clusters of human pluripotent stem cells and seem capable of mimicking early human development with increasing accuracy. Notwithstanding, hELS research finds itself at the intersection of historically controversial fields, and the expectation that it might be received as similarly sensitive is prompting proactive law reform in many jurisdictions, including the Netherlands. However, studies on the public perception of hELS research remain scarce. To help guide policymakers and fill this gap in the literature, we conducted an explorative qualitative study aimed at mapping the range of perspectives in the Netherlands on the creation and research use of hELS. This article reports on a subset of our findings, namely those pertaining to (the degrees of and requirements for) confidence in research with hELS and its regulation. Despite commonly found disparities in confidence on emerging biotechnologies, we also found wide consensus regarding the requirements for having (more) confidence in hELS research. We conclude by reflecting on how these findings could be relevant to researchers and (Dutch) policymakers when interpreted within the context of their limitations.

show abstract

The Ethics of Stem Cell-Based Embryo-Like Structures

Pereira Daoud,

Dondorp,

Bredenoord

et al. 2024

Bioethical Inquiry

View full text Add to dashboard Cite

show abstract

Organoids: Expanding Applications Enabled by Emerging Technologies

Pak

Sun

2022

Journal of Molecular Biology

View full text Add to dashboard Cite

Engineering a computable epiblast for in silico modeling of developmental toxicity

Barham,

Spencer,

Baker

et al. 2024

Reproductive Toxicology

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Stem Cell-Based Embryo Models: En Route to a Programmable Future

Cited by 5 publications

References 76 publications

The Ethics of Stem Cell-Based Embryo-Like Structures

The Ethics of Stem Cell-Based Embryo-Like Structures

Organoids: Expanding Applications Enabled by Emerging Technologies

Engineering a computable epiblast for in silico modeling of developmental toxicity

Contact Info

Product

Resources

About