Stem cell-biomaterial interactions for regenerative medicine

Martino, Sabata; D’Angelo, Francesco; Armentano, Ilaria; Kenny, J. M.; Orlacchio, Aldo

doi:10.1016/j.biotechadv.2011.06.015

Cited by 194 publications

(172 citation statements)

References 249 publications

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“…Five general bone progenitor cell types are currently been used for bone regeneration: embryonic stem cells; fetal stem cells (e.g., fetal mesenchymal stem cells [MSCs]); human umbilical vein endothelial cells; induced pluripotent stem cells (iPSCs) [22,23]; and adult stem cells (e.g., bone marrow stromal cells, bone marrow-derived MSCs, adipose-derived MSCs [24,25], muscle-derived MSCs) [26,27], dental pluripotent stem cells [28], and iPSCs. Thus far, bone marrow-derived MSCs have shown the greatest bone repair potential.…”

Section: Cell-based Therapiesmentioning

confidence: 99%

The Potential Impact of Bone Tissue Engineering in the Clinic

et al. 2016

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Bone tissue engineering (BTE) intends to restore structural support for movement and mineral homeostasis, and assist in hematopoiesis and the protective functions of bone in traumatic, degenerative, cancer, or congenital malformation. While much effort has been put into BTE, very little of this research has been translated to the clinic. In this review, we discuss current regenerative medicine and restorative strategies that utilize tissue engineering approaches to address bone defects within a clinical setting. These approaches involve the primary components of tissue engineering: cells, growth factors and biomaterials discussed briefly in light of their clinical relevance. This review also presents upcoming advanced approaches for BTE applications and suggests a probable workpath for translation from the laboratory to the clinic.

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Section: Cell-based Therapiesmentioning

confidence: 99%

The Potential Impact of Bone Tissue Engineering in the Clinic

et al. 2016

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“…Somatic and stem cells are two suitable sources for regeneration of tissue. Stem cells have the capacity to proliferate and differentiate into various cellular lineages [8,9]. There are different classifications of stem cells which embryonic stem cells (ESCs) and adult stem cells (ASCs) are two types of these cells.…”

Section: Types Of Stem Cellsmentioning

confidence: 99%

Treatment of Neurodegenerative Diseases with Using of Stem Cells/Scaffolds

Ghorbani

Eyni

2016

MOJAP

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Over the two decades, stem cell technologies have become an increasingly attractive option to treat neurodegenerative diseases. However, this approach has been limited due to transplanted cell death because of the unsuitable microenvironment. Tissue engineering by using of stem cells, scaffolds and growth factors comes to improve the chance of regeneration. In the current mini-review, we discuss the advantages of synthetic extra cellular matrix for stem cell-based therapies in patients suffering from neurodegenerative diseases. Hence, explained about biological and mechanical properties of scaffolds in nerve engineered tissues. There is growing public hope with a greater understanding of the capacity of stem cell technologies that regenerative medicine will continue to progress into effective treatments for neurodegenerative diseases.

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“…One example is the design of surfaces that exhibit dynamic changes in interfacial properties, such as wettability, in response to an electrical potential [20]. Hence, a large number of exploratory studies on the induction mechanism of the biomaterial have been carried out, and generally they believed that biological materials play a key role in the regulation of stem cell differentiation behavior in tissue induction, which are closely related to the biomaterial's composition and structure, especially surface chemistry, physical, biomechanical characteristics and geometric characteristics [21][22][23].…”

Section: Biomaterials Environmental Effects On Mesenchymal Stem Cells mentioning

confidence: 99%