Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders

Riazifar, Milad; Mohammadi, M. Rezaa; Pone, Egest J.; Yeri, Ashish; Lässer, Cecilia; Ségaliny, Aude I.; McIntyre, Laura L.; Shelke, Ganesh Vilas; Hutchins, Elizabeth; Hamamoto, Ashley; Calle, Erika N.; Crescitelli, Rossella; Liao, Wenbin; Pham, Victor; Yin, Yanan; Jayaraman, Jayapriya; Lakey, Jonathan R. T.; Walsh, Craig M.; Keuren‐Jensen, Kendall Van; Lötvall, Jan; Zhao, Weian

doi:10.1021/acsnano.9b01004

Cited by 415 publications

(381 citation statements)

References 98 publications

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“…From then on, MEVs have been increasingly considered as substitutes for MSCs in drug delivery. Efforts have been made to improve the efficacy of MEV-based drug delivery for clinical use (Cheng et al, 2018b;Lang et al, 2018;Sharif et al, 2018;Jo et al, 2019;Li et al, 2019a;Perets et al, 2019;Riazifar et al, 2019). For example, a good manufacturing practice (GMP) standard for large-scale clinical MEVs production based on bioreactor has been established (Mendt et al, 2018).…”

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

Prospects and challenges of extracellular vesicle-based drug delivery system: considering cell source

et al. 2020

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Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are nanosized membrane vesicles derived from most cell types. Carrying diverse biomolecules from their parent cells, EVs are important mediators of intercellular communication and thus play significant roles in physiological and pathological processes. Owing to their natural biogenesis process, EVs are generated with high biocompatibility, enhanced stability, and limited immunogenicity, which provide multiple advantages as drug delivery systems (DDSs) over traditional synthetic delivery vehicles. EVs have been reported to be used for the delivery of siRNAs, miRNAs, protein, small molecule drugs, nanoparticles, and CRISPR/Cas9 in the treatment of various diseases. As a natural drug delivery vectors, EVs can penetrate into the tissues and be bioengineered to enhance the targetability. Although EVs' characteristics make them ideal for drug delivery, EV-based drug delivery remains challenging, due to lack of standardized isolation and purification methods, limited drug loading efficiency, and insufficient clinical grade production. In this review, we summarized the current knowledge on the application of EVs as DDS from the perspective of different cell origin and weighted the advantages and bottlenecks of EV-based DDS. ARTICLE HISTORY

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Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

Prospects and challenges of extracellular vesicle-based drug delivery system: considering cell source

et al. 2020

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“…Based on the EVs roles in EAE and MS, some groups developed treatment strategies that employed the function of exosomes. Exosomes (IFNγ-Exo) produced by IFNγ-stimulated MSCs have shown a good therapeutic effect on EAE [103]. These data provided evidence that MSCs-derived exosomes can be used as cell-free therapies for autoimmune and central nervous system diseases.…”

Section: Multiple Sclerosis (Ms)mentioning

confidence: 80%

Potential roles of extracellular vesicles in the pathophysiology, diagnosis, and treatment of autoimmune diseases

Tian¹,

Casella²,

Zhang³

et al. 2020

Int. J. Biol. Sci.

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Since extracellular vesicles (EVs) were discovered in 1983 in sheep reticulocytes samples, they have gradually attracted scientific attention and become a topic of great interest in the life sciences field. EVs are small membrane particles, released by virtually every cell that carries a variety of functional molecules. Their main function is to deliver messages to the surrounding area in both physiological and pathological conditions. Initially, they were thought to be either cell debris, signs of cell death, or unspecific structures. However, accumulating evidence support a theory that EVs are a universal mechanism of communication. Thanks to their biological characteristics and functions, EVs are likely to represent a promising strategy for obtaining pathogen information, identifying therapeutic targets and selecting specific biomarkers for a variety of diseases, such as autoimmune diseases. In this review, we provide a brief overview of recent progress in the study of the biology and functions of EVs. We also discuss their roles in diagnosis and therapy, with particular emphasis on autoimmune diseases.

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“…Apoptotic MSCs have demonstrated immunosuppressive properties in mouse models of GVHD [38], and extracellular vesicles have improved the symptoms associated with uveitis/uveoretinitis and type I diabetes mellitus [76]. In addition, exosomes have shown success in ameliorating autoimmune conditions including multiple sclerosis [77], Sjögren's syndrome [78], graft versus host disease [59], systemic lupus erythematosus [79], and rheumatoid arthritis [80]. These results suggest the potential use of derivatives for other autoimmune conditions that lack entirely favorable treatment regimens, such as autoimmune pancreatitis.…”

Section: Live Cells Dead Cells and Derivativesmentioning

confidence: 99%

Mesenchymal stromal cells and their derivatives – putative therapeutics in the management of autoimmune pancreatitis

Goodman

Davies

2020

FEBS Open Bio

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Autoimmune pancreatitis, a derivative of chronic pancreatitis, frequently causes acute episodes with clinical symptoms parallel to those of acute pancreatitis. Corticosteroids are effective in the treatment of 90% of autoimmune pancreatitis cases, but for the remaining 10%, options are limited. Due to their significant immunomodulatory capabilities, mesenchymal stromal cells (MSCs) have been proposed as a novel treatment strategy for various immune and inflammatory pathologies including those with autoimmune origins. Here, we not only highlight the most recent MSC live‐cell experiments to address acute pancreatitis, but also discuss the opportunities afforded by the emergence of the newly identified field of MSC necrobiology. We conclude that the putative employment of MSC derivatives provides a newer and simpler therapeutic approach that could have significant advantages over the use of cells themselves.

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Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders

Cited by 415 publications

References 98 publications

Prospects and challenges of extracellular vesicle-based drug delivery system: considering cell source

Prospects and challenges of extracellular vesicle-based drug delivery system: considering cell source

Potential roles of extracellular vesicles in the pathophysiology, diagnosis, and treatment of autoimmune diseases

Mesenchymal stromal cells and their derivatives – putative therapeutics in the management of autoimmune pancreatitis

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