Stem cell-derived exosomes in bone healing: focusing on their role in angiogenesis

Editorial: Methods and application in integrative and regenerative pharmacology: 2021

“…Advances in the field of biomaterials for stem cell and drug delivery in the last decade have given a much-needed boost to the development of regenerative medicine (Sankar et al, 2017;Farokhi et al, 2021;Pishavar et al, 2021;Irfan et al, 2022;Maruthi and Ramakrishna, 2022). The research progress and development in the field of RNA interference (RNAi) and RNA activation (RNAa) (Li et al, 2006;Pushparaj et al, 2008a;Pushparaj et al, 2008b;Li, 2017;Tan et al, 2021), CRISPR-CAS9 gene editing methods, and the potential application of next-generation knowledge discovery platforms in basic and translational research (Pushparaj et al, 2022) in integrative and regenerative pharmacology are essential for the development of personalized therapies (Figure 1).…”

“…The last decade has seen notable developments in the research environment of integrative and regenerative pharmacology (Richardson et al, 2016;Huwaikem et al, 2021;Irfan et al, 2022;Rani Raju, et al, 2022). Therefore, the Integrative and Regenerative Pharmacology special issue series aims to highlight the state-of-the-art experimental methods to explore fundamental issues and application of biomolecules in stem cell biology and the use of pharmacological agents in conjunction with biotechnological and nanotechnological principles.…”

Recent trends in bone tissue engineering: a review of materials, methods, and structures

“…Various regenerative characteristics of stem cells, especially MSCs, have been confirmed to be managed through secreted exosomes [289]. Indeed, MSC-DEs can improve the treatment of damaged tissues; for example, exosomal angiogenic factors such as VEGF and IL-6 increase bone growth and fracture remodeling by stimulating endothelial cells [290]. MSC-DEs have been widely reported to polarize monocytes toward corresponding phenotypes (majorly toward an anti-inflammatory M2 phenotype).…”

Toward the Improvement of the Mechanical and Tribological Properties of Braided Ligament for ACL Reconstruction: A “Carrot and Stick” Strategy

“…ACL is an avascular tissue composed of anisotropic bundles encapsulated by a surrounding sheath. [11,22] Current research on ACL reconstruction generally focuses on lowering cytotoxicity and enhancing bioactivation, however, few attempted to alleviate complication rate via mechanical and tribological performance optimization. In this study, texture modification and heat treatment were adopted as the main methods to attaining a material control toward enhancement of tribological performance and deformation resistance, without yielding cytotoxicity and tensile strength, in a wish to contribute to isometric reconstruction and avoid possible bone tunnel enlargement.…”