Stem-Cell-Derived Extracellular Vesicles: Unlocking New Possibilities for Treating Diminished Ovarian Reserve and Premature Ovarian Insufficiency

Martirosyan, Yana O.; Silachev, Denis N.; Nazarenko, Tatiana A.; Birukova, Almina M.; Vishnyakova, Polina A.; Sukhikh, Gennadiy T.

doi:10.3390/life13122247

Cited by 4 publications

(3 citation statements)

References 191 publications

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“…In addition, O 3 exposure is inversely related to the ovarian reserve. It is found that exposure to O 3 is positively associated with low excretion of anti-Muellerian hormone (AMH), an important marker for ovarian reserve ( 32 ). However, some studies showed that exposure to O 3 was effective in treating female infertility.…”

Section: Endocrine Disruptive Effects Of Gaseous Constituents Of Smogmentioning

confidence: 99%

A comprehensive review on endocrine toxicity of gaseous components and particulate matter in smog

Saleem,

Awan,

Akhtar

2024

Front. Endocrinol.

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Smog is a form of extreme air pollution which comprises of gases such as ozone, sulfur dioxide, nitrogen and carbon oxides, and solid particles including particulate matter (PM2.5 and PM10). Different types of smog include acidic, photochemical, and Polish. Smog and its constituents are hazardaous to human, animals, and plants. Smog leads to plethora of morbidities such as cancer, endocrine disruption, and respiratory and cardiovascular disorders. Smog components alter the activity of various hormones including thyroid, pituitary, gonads and adrenal hormones by altering regulatory genes, oxidation status and the hypothalamus-pituitary axis. Furthermore, these toxicants are responsible for the development of metabolic disorders, teratogenicity, insulin resistance, infertility, and carcinogenicity of endocrine glands. Avoiding fossil fuel, using renewable sources of energy, and limiting gaseous discharge from industries can be helpful to avoid endocrine disruption and other toxicities of smog. This review focuses on the toxic implications of smog and its constituents on endocrine system, their toxicodynamics and preventive measures to avoid hazardous health effects.

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Section: Endocrine Disruptive Effects Of Gaseous Constituents Of Smogmentioning

confidence: 99%

A comprehensive review on endocrine toxicity of gaseous components and particulate matter in smog

Saleem,

Awan,

Akhtar

2024

Front. Endocrinol.

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“…Owing to the deleterious impact of environmental pollution, psychological stress, and unhealthy lifestyles, infertility has witnessed a marked uptick in recent years and emerged as a pressing global health issue [ 1 , 2 , 3 , 4 ]. In a recent report published by the World Health Organization in 2022, it was estimated that the global prevalence of infertility stands at 17.5%, with the Western Pacific region exhibiting the highest rates, peaking at 23.2% [ 5 , 6 ]. Over the past two decades, China has witnessed a rise in infertility rates among those of reproductive age from 2.5–3.0% to 12.5–18.0% [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Metabolomic Analysis Reveals Association between Decreased Ovarian Reserve and In Vitro Fertilization Outcomes

An,

Zhang,

Zhu

et al. 2024

Metabolites

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In vitro fertilization (IVF) is a highly effective treatment for infertility; however, it poses challenges for women with decreased ovarian reserve (DOR). Despite the importance of understanding the impact of DOR on IVF outcomes, limited research has explored this relationship, particularly using omics approaches. Hence, we conducted a study to investigate the association between DOR and IVF outcomes, employing a metabolomic approach. We analyzed serum samples from 207 women undergoing IVF treatment, including 89 with DOR and 118 with normal ovarian reserve (NOR). Our findings revealed that DOR was significantly associated with unfavorable IVF outcomes, characterized by a reduced oocyte count, lower embryo quality, and decreased rates of pregnancy and live births. Furthermore, we identified 82 metabolites that displayed significant alterations in DOR patients, impacting diverse metabolic pathways. Notably, a distinct panel of metabolites, including palmitic acid, stearic acid, LysoPC(9:0(CHO)/0:0), PC(18:0/9:0(CHO)), and PC(16:0/9:0(CHO)), exhibited discriminatory power between the DOR and NOR groups, showcasing a strong correlation with IVF outcomes. These findings emphasize the crucial role of metabolomic disruptions in influencing IVF outcomes among women with DOR.

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“…Still, data from clinical trials are still inconclusive as to HUMSCs' safety for the restoration of reproductive aging [34]. Amniotic fluid stem cells have shown an ability to differentiate into granulosa cells, which can counter or prevent follicular atresia and keep follicles healthy [35]. Still, more conclusive data are needed for human applications, since currently available results of MSC research in female-infertility-related diseases are mostly limited to findings in animal models and the underlying dynamics involving MSCs and several conditions causing female infertility have not yet been clarified [36].…”

mentioning

confidence: 99%

Stem Cells and Infertility: A Review of Clinical Applications and Legal Frameworks

Cucinella,

Gullo,

Catania

et al. 2024

JPM

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Infertility is a condition defined by the failure to establish a clinical pregnancy after 12 months of regular, unprotected sexual intercourse or due to an impairment of a person’s capacity to reproduce either as an individual or with their partner. The authors have set out to succinctly investigate, explore, and assess infertility treatments, harnessing the potential of stem cells to effectively and safely treat infertility; in addition, this paper will present the legal and regulatory complexities at the heart of stem cell research, with an overview of the legislative state of affairs in six major European countries. For couples who cannot benefit from assisted reproductive technologies (ART) to treat their infertility, stem-cells-based approaches have been shown to be a highly promising approach. Nonetheless, lingering ethical and immunological uncertainties require more conclusive findings and data before such treatment avenues can become mainstream and be applied on a large scale. The isolation of human embryonic stem cells (ESCs) is ethically controversial, since their collection involves the destruction of human embryonic tissue. Overall, stem cell research has resulted in important new breakthroughs in the treatment of infertility. The effort to untangle the complex web of ethical and legal issues associated with such therapeutic approaches will have to rely on evidence-based, broadly shared standards, guidelines, and best practices to make sure that the procreative rights of patients can be effectively reconciled with the core values at the heart of medical ethics.

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Stem-Cell-Derived Extracellular Vesicles: Unlocking New Possibilities for Treating Diminished Ovarian Reserve and Premature Ovarian Insufficiency

Cited by 4 publications

References 191 publications

A comprehensive review on endocrine toxicity of gaseous components and particulate matter in smog

A comprehensive review on endocrine toxicity of gaseous components and particulate matter in smog

Metabolomic Analysis Reveals Association between Decreased Ovarian Reserve and In Vitro Fertilization Outcomes

Stem Cells and Infertility: A Review of Clinical Applications and Legal Frameworks

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