Stem Cell Markers in Colon Cancer

Pop, Miana Gabriela

doi:10.5772/intechopen.84315

Cited by 2 publications

References 73 publications

(118 reference statements)

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CD133 and CD166 as stem cell markers for predicting the possibility of developing prostatic cancer in cases of benign prostatic hyperplasia

Noel

Ibraheem

Ahmed

et al. 2019

Biomed. Pharmacol. J.

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Benign and malignant prostatic diseases are generally well-known in the world. Accordingly, this research is planned to assess the immunohistochemical analysis of CD133 and CD166 in the prostatic epithelium in samples of benign prostatic hyperplasia (BPH) and normal looking epithelium around prostatic adenocarcinoma samples (PCa) and to explore the opportunity of malignant alterations in benign tissue. The prostate samples were divided into 2 groups; 50 BPH samples, and 50 normally looking tissue surrounding prostatic carcinoma samples (NPCA). The samples were treated for immunohistochemical examination of CD133 and CD166. Over expression of CD133 appeared in the BPH group which was statistically significant as compared to NPCA group. Conversely, over expression of CD166 stem cell marker in NPCA group than BPH group as it was significant statistically. CD166 is a stem cell marker for tissue tumorigenicity, while the positive expression of CD133 is not of value for cancer initiation.

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CD133 and CD166 as stem cell markers for predicting the possibility of developing prostatic cancer in cases of benign prostatic hyperplasia

Noel

Ibraheem

Ahmed

et al. 2019

Biomed. Pharmacol. J.

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Role of Cancer Stem Cells in Colitis-Associated Colorectal Cancer

Sekar

2021

Diagnostic and Treatment Methods for Ulcerative Colitis and Colitis-Associated Cancer

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Colorectal cancer the third-leading cause of cancer mortality Worldwide; it's a well characterised model at molecular level among various cancera. Chronic ulcerative colitis is one of the causes of colorectal cancer. Recent cancer research focuses on tumor-initiating cells which are the cause of tumor initiation, invasions, drug-resistant, recurrence, and metastasis. Emerging research findings support the presence of colon cancer stem cells in sporadic colorectal cancer and in colitis-associated colorectal cancer. Colitis-associated cancer cells exhibit increased colon cancer stem cell marker expression along with activated developmental signaling pathways. Also, emerging reports exhibit that inhibition stem cell markers in chronic ulcerative colitis cells impedes progression of cancer in genetically engineered animal models and primary samples. This chapter deals of colitis-cancer transition, microenvironment of colitis-associated colorectal cancer, and articulates that cancer stem cells are ideal targets for colorectal cancer.

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Stem Cell Markers in Colon Cancer

Cited by 2 publications

References 73 publications

CD133 and CD166 as stem cell markers for predicting the possibility of developing prostatic cancer in cases of benign prostatic hyperplasia

CD133 and CD166 as stem cell markers for predicting the possibility of developing prostatic cancer in cases of benign prostatic hyperplasia

Role of Cancer Stem Cells in Colitis-Associated Colorectal Cancer

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